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CDK19 cyclin dependent kinase 19 [ Homo sapiens (human) ]

Gene ID: 23097, updated on 11-Apr-2024

Summary

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Official Symbol
CDK19provided by HGNC
Official Full Name
cyclin dependent kinase 19provided by HGNC
Primary source
HGNC:HGNC:19338
See related
Ensembl:ENSG00000155111 MIM:614720; AllianceGenome:HGNC:19338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3
Summary
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
6q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110609978..110815855, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (111788546..111994459, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110931181..111137058, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24935 Neighboring gene abhydrolase domain containing 10, depalmitoylase pseudogene Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110967777-110968713 Neighboring gene ribosomal protein S20 pseudogene 18 Neighboring gene uncharacterized LOC124901502 Neighboring gene RNA, U6 small nuclear 957, pseudogene Neighboring gene Sharpr-MPRA regulatory region 10405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24937 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111135767-111136319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24938 Neighboring gene MPRA-validated peak6028 silencer Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene RNA, U6 small nuclear 1115, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 40C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma. Cai X, et al. BMC Gastroenterol, 2021 Oct 14. PMID 34649520, Free PMC Article
  2. A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms. Yang S, et al. Cold Spring Harb Mol Case Stud, 2021 Apr. PMID 33568421, Free PMC Article
  3. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. Zarate YA, et al. Genet Med, 2021 Jun. PMID 33495529
  4. CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC. Paulsen FO, et al. Int J Mol Sci, 2020 Jul 31. PMID 32752128, Free PMC Article
  5. Increased mediator complex subunit CDK19 expression associates with aggressive prostate cancer. Becker F, et al. Int J Cancer, 2020 Jan 15. PMID 31271443

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
    Title: CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.
  2. CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
    Title: CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.
  3. Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
    Title: Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.
  4. Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.
    Title: Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis.
  5. CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
    Title: CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21.
  6. A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.
    Title: A novel variant of CDK19 causes a severe neurodevelopmental disorder with infantile spasms.
  7. Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
    Title: Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.
  8. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
    Title: CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants.
  9. ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.
    Title: ISOC1 promotes the proliferation of gastric cancer cells by positively regulating CDK19.
  10. CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
    Title: CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 87
MedGen: C5394501 OMIM: 618916 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CKM complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 19
Names
CDC2-related protein kinase 6
CDK8-like cyclin-dependent kinase
cell division cycle 2-like 6 (CDK8-like)
cell division cycle 2-like protein kinase 6
cell division protein kinase 19
cyclin-dependent kinase (CDC2-like) 11
cyclin-dependent kinase 11
death-preventing kinase
NP_001287889.1
NP_001287892.1
NP_001287893.1
NP_055891.1
XP_005266928.1
XP_011533932.2
XP_024302144.2
XP_024302145.1
XP_024302146.1
XP_024302148.1
XP_047274421.1
XP_047274423.1
XP_047274424.1
XP_047274425.1
XP_047274426.1
XP_047274427.1
XP_047274428.1
XP_047274429.1
XP_054210782.1
XP_054210783.1
XP_054210784.1
XP_054210785.1
XP_054210786.1
XP_054210787.1
XP_054210788.1
XP_054210789.1
XP_054210790.1
XP_054210791.1
XP_054210792.1
XP_054210793.1
XP_054210794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300960.2 → NP_001287889.1  cyclin-dependent kinase 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB028951, AY028424, JX028238, Z84480
    UniProtKB/TrEMBL
    I6W807
    Conserved Domains (2) summary
    smart00220
    Location:22 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:18 → 291
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001300963.2 → NP_001287892.1  cyclin-dependent kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001287892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AB028951, BC024247, Z84480
    Consensus CDS
    CCDS75503.1
    UniProtKB/TrEMBL
    A8K8J5
    Related
    ENSP00000317665.3, ENST00000323817.7
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001300964.2 → NP_001287893.1  cyclin-dependent kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001287893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AB028951, DB030002
    Consensus CDS
    CCDS75503.1
    UniProtKB/TrEMBL
    A8K8J5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  4. NM_015076.5 → NP_055891.1  cyclin-dependent kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_055891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB028951, AY028424, Z84480
    Consensus CDS
    CCDS5085.1
    UniProtKB/Swiss-Prot
    Q5JQZ7, Q5JR00, Q8TC78, Q9BWU1, Q9UPX2
    UniProtKB/TrEMBL
    A8K8J5
    Related
    ENSP00000357907.3, ENST00000368911.8
    Conserved Domains (1) summary
    cd07867
    Location:18 → 335
    STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    110609978..110815855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418470.1 → XP_047274426.1  cyclin-dependent kinase 19 isoform X6

  2. XM_011535630.3 → XP_011533932.2  cyclin-dependent kinase 19 isoform X4

    UniProtKB/TrEMBL
    F6QTA4
    Related
    ENSP00000410604.3, ENST00000413605.6

  3. XM_024446376.2 → XP_024302144.2  cyclin-dependent kinase 19 isoform X2

  4. XM_047418467.1 → XP_047274423.1  cyclin-dependent kinase 19 isoform X2

  5. XM_047418469.1 → XP_047274425.1  cyclin-dependent kinase 19 isoform X3

  6. XM_024446377.2 → XP_024302145.1  cyclin-dependent kinase 19 isoform X2

    UniProtKB/TrEMBL
    A8K8J5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  7. XM_024446380.2 → XP_024302148.1  cyclin-dependent kinase 19 isoform X2

    UniProtKB/TrEMBL
    A8K8J5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  8. XM_024446378.2 → XP_024302146.1  cyclin-dependent kinase 19 isoform X2

    UniProtKB/TrEMBL
    A8K8J5
    Conserved Domains (1) summary
    cl21453
    Location:1 → 275
    PKc_like; Protein Kinases, catalytic domain

  9. XM_047418468.1 → XP_047274424.1  cyclin-dependent kinase 19 isoform X2

  10. XM_047418465.1 → XP_047274421.1  cyclin-dependent kinase 19 isoform X1

  11. XM_047418471.1 → XP_047274427.1  cyclin-dependent kinase 19 isoform X7

  12. XM_005266871.4 → XP_005266928.1  cyclin-dependent kinase 19 isoform X5

    See identical proteins and their annotated locations for XP_005266928.1

    UniProtKB/TrEMBL
    B4DUB1, Q9UFE3
    Conserved Domains (1) summary
    cl21453
    Location:28 → 211
    PKc_like; Protein Kinases, catalytic domain

  13. XM_047418472.1 → XP_047274428.1  cyclin-dependent kinase 19 isoform X7

  14. XM_047418473.1 → XP_047274429.1  cyclin-dependent kinase 19 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    111788546..111994459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354815.1 → XP_054210790.1  cyclin-dependent kinase 19 isoform X6

  2. XM_054354813.1 → XP_054210788.1  cyclin-dependent kinase 19 isoform X4

    UniProtKB/TrEMBL
    F6QTA4

  3. XM_054354807.1 → XP_054210782.1  cyclin-dependent kinase 19 isoform X2

  4. XM_054354812.1 → XP_054210787.1  cyclin-dependent kinase 19 isoform X3

  5. XM_054354819.1 → XP_054210794.1  cyclin-dependent kinase 19 isoform X2

  6. XM_054354810.1 → XP_054210785.1  cyclin-dependent kinase 19 isoform X2

  7. XM_054354809.1 → XP_054210784.1  cyclin-dependent kinase 19 isoform X2

  8. XM_054354808.1 → XP_054210783.1  cyclin-dependent kinase 19 isoform X2

  9. XM_054354811.1 → XP_054210786.1  cyclin-dependent kinase 19 isoform X2

  10. XM_054354816.1 → XP_054210791.1  cyclin-dependent kinase 19 isoform X7

  11. XM_054354814.1 → XP_054210789.1  cyclin-dependent kinase 19 isoform X5

    UniProtKB/TrEMBL
    B4DUB1

  12. XM_054354817.1 → XP_054210792.1  cyclin-dependent kinase 19 isoform X7

  13. XM_054354818.1 → XP_054210793.1  cyclin-dependent kinase 19 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWU1.1 GenPept UniProtKB/Swiss-Prot:Q9BWU1

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