U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GOLGA8A golgin A8 family member A [ Homo sapiens (human) ]

Gene ID: 23015, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GOLGA8Aprovided by HGNC
Official Full Name
golgin A8 family member Aprovided by HGNC
Primary source
HGNC:HGNC:31972
See related
Ensembl:ENSG00000175265 MIM:616180; AllianceGenome:HGNC:31972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM88; FAP286; CFAP286; GOLGA8B
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 77.6), testis (RPKM 53.7) and 24 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q14
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34379068..34437808, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32184804..32243499, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34671269..34730009, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6283 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:34659557-34660552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9181 Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene microRNA 1233-1 Neighboring gene amyloid beta precursor protein binding family A member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34710454-34710954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:34710955-34711455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6286 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:34782687-34783188 Neighboring gene heterogeneous nuclear ribonucleoprotein L pseudogene 2 Neighboring gene fascin actin-bundling protein 1 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of Plasma Biomarkers of Human Intracerebral Hemorrhage Subtypes through Microarray Technology. Merino-Zamorano C, et al. J Stroke Cerebrovasc Dis, 2016 Mar. PMID 26738811
  2. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. Eystathioy T, et al. J Autoimmun, 2000 Mar. PMID 10677249
  3. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw A, et al. J Biol Chem, 2000 Feb 11. PMID 10660574
  4. Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1. Berthel E, et al. Cells, 2020 Apr 10. PMID 32290274, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in Golgi cis cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi cisterna membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
golgin subfamily A member 8A
Names
88 kDa Golgi matrix protein
88-kDa golgi protein
GM88 autoantigen
Golgin subfamily A member 8B
golgi autoantigen, golgin subfamily a, 8A
golgin-67

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368071.2 → NP_001355000.1  golgin subfamily A member 8A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform 2.
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS91979.1
    UniProtKB/TrEMBL
    A0A8V8TPN8, B7ZKM1
    Related
    ENSP00000514395.1, ENST00000699472.1

  2. NM_001368072.2 → NP_001355001.1  golgin subfamily A member 8A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform 2.
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS91979.1
    UniProtKB/TrEMBL
    A0A8V8TPN8, B7ZKM1

  3. NM_001386893.1 → NP_001373822.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform 1.
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS10038.1
    UniProtKB/TrEMBL
    B7ZKM1
    Conserved Domains (3) summary
    TIGR02168
    Location:78 → 439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218 → 397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558 → 603
    GM130_C; GM130 C-terminal binding motif

  4. NM_001386895.1 → NP_001373824.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform 1.
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS10038.1
    UniProtKB/TrEMBL
    B7ZKM1
    Conserved Domains (3) summary
    TIGR02168
    Location:78 → 439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218 → 397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558 → 603
    GM130_C; GM130 C-terminal binding motif

  5. NM_181077.5 → NP_851422.1  golgin subfamily A member 8A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC025678
    Consensus CDS
    CCDS10038.1
    UniProtKB/TrEMBL
    B7ZKM1
    Related
    ENSP00000352111.4, ENST00000359187.5
    Conserved Domains (3) summary
    TIGR02168
    Location:78 → 439
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15070
    Location:218 → 397
    GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
    pfam19046
    Location:558 → 603
    GM130_C; GM130 C-terminal binding motif

RNA

  1. NR_027409.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate upstream promoter, contains additional 5' exons, and retains an intron, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025678

  2. NR_164784.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025678

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34379068..34437808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432259.1 → XP_047288215.1  golgin subfamily A member 8A isoform X1

  2. XM_047432261.1 → XP_047288217.1  golgin subfamily A member 8A isoform X1

  3. XM_047432258.1 → XP_047288214.1  golgin subfamily A member 8A isoform X1

    Related
    ENST00000473125.5

  4. XM_047432256.1 → XP_047288212.1  golgin subfamily A member 8A isoform X1

  5. XM_047432257.1 → XP_047288213.1  golgin subfamily A member 8A isoform X1

  6. XM_047432260.1 → XP_047288216.1  golgin subfamily A member 8A isoform X1

  7. XM_047432262.1 → XP_047288218.1  golgin subfamily A member 8A isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791798.1 Reference GRCh38.p14 PATCHES

    Range
    125171..183900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333174.1 → XP_054189149.1  golgin subfamily A member 8A isoform X3

  2. XM_054333179.1 → XP_054189154.1  golgin subfamily A member 8A isoform X3

  3. XM_054333176.1 → XP_054189151.1  golgin subfamily A member 8A isoform X3

  4. XM_054333180.1 → XP_054189155.1  golgin subfamily A member 8A isoform X4

  5. XM_054333173.1 → XP_054189148.1  golgin subfamily A member 8A isoform X3

  6. XM_054333177.1 → XP_054189152.1  golgin subfamily A member 8A isoform X3

  7. XM_054333178.1 → XP_054189153.1  golgin subfamily A member 8A isoform X3

  8. XM_054333175.1 → XP_054189150.1  golgin subfamily A member 8A isoform X3

  9. XM_054333181.1 → XP_054189156.1  golgin subfamily A member 8A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32184804..32243499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377546.1 → XP_054233521.1  golgin subfamily A member 8A isoform X4

  2. XM_054377547.1 → XP_054233522.1  golgin subfamily A member 8A isoform X4

  3. XM_054377544.1 → XP_054233519.1  golgin subfamily A member 8A isoform X3

  4. XM_054377545.1 → XP_054233520.1  golgin subfamily A member 8A isoform X3

  5. XM_054377542.1 → XP_054233517.1  golgin subfamily A member 8A isoform X3

  6. XM_054377543.1 → XP_054233518.1  golgin subfamily A member 8A isoform X3

  7. XM_054377541.1 → XP_054233516.1  golgin subfamily A member 8A isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015003.4: Suppressed sequence

    Description
    NM_015003.4: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_181076.2: Suppressed sequence

    Description
    NM_181076.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7E2F4.3 GenPept UniProtKB/Swiss-Prot:A7E2F4
A8MQT2.2 GenPept UniProtKB/Swiss-Prot:A8MQT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous