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PLCH1 phospholipase C eta 1 [ Homo sapiens (human) ]

Gene ID: 23007, updated on 5-Mar-2024

Summary

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Official Symbol
PLCH1provided by HGNC
Official Full Name
phospholipase C eta 1provided by HGNC
Primary source
HGNC:HGNC:29185
See related
Ensembl:ENSG00000114805 MIM:612835; AllianceGenome:HGNC:29185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPE14; PLCL3; PLC-L3; PLC eta 1
Summary
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in testis (RPKM 4.0), thyroid (RPKM 1.7) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q25.31
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (155450934..155745071, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (158220392..158518944, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (155197670..155462860, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155139477-155140078 Neighboring gene DTWD1 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 715, pseudogene Neighboring gene PLCH1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14832 Neighboring gene PLCH1 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155229919-155230575 Neighboring gene uncharacterized LOC124906297 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:155336094-155336620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:155336621-155337145 Neighboring gene NANOG hESC enhancer GRCh37_chr3:155337230-155337774 Neighboring gene ribosomal protein L6 pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:155462097-155462718 Neighboring gene ribosomal protein L7a pseudogene 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:155507600-155507774 Neighboring gene chromosome 3 open reading frame 33 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:155508647-155509846 Neighboring gene MPRA-validated peak4874 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly. Drissi I, et al. J Med Genet, 2022 Apr. PMID 33820834, Free PMC Article
  2. A canonical EF-loop directs Ca(2+) -sensitivity in phospholipase C-η2. Popovics P, et al. J Cell Biochem, 2014 Mar. PMID 24123053
  3. Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers. Zhang Y, et al. Clin Lung Cancer, 2013 Jan. PMID 22658813
  4. Expression profile of PLCζ, PAWP, and TR-KIT in association with fertilization potential, embryo development, and pregnancy outcomes in globozoospermic candidates for intra-cytoplasmic sperm injection and artificial oocyte activation. Tavalaee M, et al. Andrology, 2016 Sep. PMID 27089467
  5. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Stewart AJ, et al. Int J Mol Med, 2005 Jan. PMID 15583837

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly.
    Title: Mutations in phospholipase C eta-1 (PLCH1) are associated with holoprosencephaly.
  2. High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals
    Title: Expression profile of PLCζ, PAWP, and TR-KIT in association with fertilization potential, embryo development, and pregnancy outcomes in globozoospermic candidates for intra-cytoplasmic sperm injection and artificial oocyte activation.
  3. A molecular model of the PLCeta2 EF-hand domain, constructed based upon the structure of calmodulin, suggested both EF-loops may participate in Ca(2+) -binding.
    Title: A canonical EF-loop directs Ca(2+) -sensitivity in phospholipase C-η2.
  4. The PLCH1 rs181696 single-nucleotide polymorphism was strongly associated with an increased risk of squamous cell carcinoma.
    Title: Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers.
  5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  7. The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain.
    Title: Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
  8. molecular cloning of PLC-eta1 and PLC-eta2
    Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Holoprosencephaly 14
MedGen: C5676994 OMIM: 619895 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117152, DKFZp434C1372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Names
PLC-eta-1
phosphoinositide phospholipase C-eta-1
phospholipase C-eta1a
phospholipase C-eta1b
phospholipase C-like 3
phospholipase C-like protein 3
NP_001124432.1
NP_001124433.1
NP_001336179.1
NP_001336180.1
NP_001336181.1
NP_055811.2
XP_005247295.1
XP_005247296.1
XP_011510862.1
XP_011510863.1
XP_011510864.1
XP_011510867.1
XP_011510868.1
XP_016861412.1
XP_016861414.1
XP_016861415.1
XP_016861416.1
XP_047303701.1
XP_047303702.1
XP_047303703.1
XP_054201713.1
XP_054201714.1
XP_054201715.1
XP_054201716.1
XP_054201717.1
XP_054201718.1
XP_054201719.1
XP_054201720.1
XP_054201721.1
XP_054201722.1
XP_054201723.1
XP_054201724.1
XP_054201725.1
XP_054201726.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130960.2 → NP_001124432.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a

    See identical proteins and their annotated locations for NP_001124432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC012022, AC132006, AK096620, AY691171, BC113950, DA206803
    Consensus CDS
    CCDS46939.1
    UniProtKB/Swiss-Prot
    Q29RV9, Q4KWH8, Q4KWH9, Q68CN0, Q86XK4, Q9H9U2, Q9UPT3
    Related
    ENSP00000345988.7, ENST00000340059.11
    Conserved Domains (8) summary
    cd00275
    Location:731 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:227 → 872
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  2. NM_001130961.2 → NP_001124433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

    See identical proteins and their annotated locations for NP_001124433.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AC012022, AC132006, AK096620, AY691170, BC113950, DA206803
    Consensus CDS
    CCDS46940.1
    UniProtKB/Swiss-Prot
    Q4KWH8
    Related
    ENSP00000402759.2, ENST00000447496.6
    Conserved Domains (4) summary
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:146 → 286
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:273 → 841
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  3. NM_001349250.2 → NP_001336179.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes isoform c.
    Source sequence(s)
    AC012022, AC132006
    Consensus CDS
    CCDS46940.1
    Related
    ENSP00000419100.1, ENST00000494598.5
    Conserved Domains (4) summary
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:146 → 286
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:273 → 841
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  4. NM_001349251.2 → NP_001336180.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform d.
    Source sequence(s)
    AC012022, AC104472, AC132006
    Conserved Domains (4) summary
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285 → 853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  5. NM_001349252.2 → NP_001336181.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform e.
    Source sequence(s)
    AC012022, AC104472, AC132006
    Conserved Domains (4) summary
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285 → 853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

  6. NM_014996.4 → NP_055811.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform b.
    Source sequence(s)
    AC012022, AC104472, AC132006
    Consensus CDS
    CCDS33881.2
    UniProtKB/TrEMBL
    A0A2U3TZV8
    Related
    ENSP00000417502.2, ENST00000460012.7
    Conserved Domains (4) summary
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain
    cl27705
    Location:285 → 853
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    155450934..155745071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005927.2 → XP_016861416.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

  2. XM_047447747.1 → XP_047303703.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

  3. XM_047447746.1 → XP_047303702.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

  4. XM_047447745.1 → XP_047303701.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

  5. XM_017005925.2 → XP_016861414.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

  6. XM_017005923.2 → XP_016861412.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

  7. XM_005247238.2 → XP_005247295.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_005247295.1

    Conserved Domains (8) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239 → 884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453 → 554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  8. XM_011512562.4 → XP_011510864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510864.1

    Conserved Domains (8) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239 → 884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453 → 554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  9. XM_011512560.4 → XP_011510862.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510862.1

    Conserved Domains (8) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239 → 884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453 → 554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  10. XM_011512561.3 → XP_011510863.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011510863.1

    Conserved Domains (8) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239 → 884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453 → 554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  11. XM_005247239.2 → XP_005247296.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    Conserved Domains (7) summary
    cd00275
    Location:731 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  12. XM_011512565.3 → XP_011510867.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    See identical proteins and their annotated locations for XP_011510867.1

    Conserved Domains (8) summary
    cd00275
    Location:713 → 837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280 → 683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209 → 854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128 → 194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209 → 280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129 → 190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423 → 524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4 → 110
    PH-like; Pleckstrin homology-like domain

  13. XM_011512566.3 → XP_011510868.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    See identical proteins and their annotated locations for XP_011510868.1

    Conserved Domains (8) summary
    cd00275
    Location:713 → 837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280 → 683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209 → 854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128 → 194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209 → 280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129 → 190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423 → 524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4 → 110
    PH-like; Pleckstrin homology-like domain

  14. XM_017005926.1 → XP_016861415.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    Conserved Domains (8) summary
    cd00275
    Location:713 → 837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280 → 683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:209 → 854
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:128 → 194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209 → 280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129 → 190
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:423 → 524
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:4 → 110
    PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    158220392..158518944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345751.1 → XP_054201726.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

  2. XM_054345750.1 → XP_054201725.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

  3. XM_054345749.1 → XP_054201724.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

  4. XM_054345744.1 → XP_054201719.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

  5. XM_054345743.1 → XP_054201718.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

  6. XM_054345742.1 → XP_054201717.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

  7. XM_054345738.1 → XP_054201713.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

  8. XM_054345741.1 → XP_054201716.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

  9. XM_054345739.1 → XP_054201714.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

  10. XM_054345740.1 → XP_054201715.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

  11. XM_054345748.1 → XP_054201723.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

  12. XM_054345746.1 → XP_054201721.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

  13. XM_054345747.1 → XP_054201722.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

  14. XM_054345745.1 → XP_054201720.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KWH8.1 GenPept UniProtKB/Swiss-Prot:Q4KWH8

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