TRIM32 tripartite motif containing 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM32provided by HGNC
Official Full Name: tripartite motif containing 32provided by HGNC
Primary source: HGNC:HGNC:16380
See related: Ensembl:ENSG00000119401 MIM:602290; AllianceGenome:HGNC:16380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HT2A; BBS11; TATIP; LGMD2H; LGMDR8
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in endometrium (RPKM 1.6), adrenal (RPKM 1.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q33.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (116687305..116701299)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (128880322..128894320)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (119449584..119463578)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.
Title: RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32.
TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation.
Title: TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation.
Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?
Title: Tripartite Motif-Containing Protein 32 (TRIM32): What Does It Do for Skeletal Muscle?
Overexpression of TRIM32 promotes pancreatic beta-cell autophagic cell death through Akt/mTOR pathway under high glucose conditions.
Title: Overexpression of TRIM32 promotes pancreatic β-cell autophagic cell death through Akt/mTOR pathway under high glucose conditions.
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3beta/Nrf2 Pathway.
Title: TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer.
Title: TRIM32 promotes radioresistance by disrupting TC45-STAT3 interaction in triple-negative breast cancer.
TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension.
Title: TRIM32 inhibits the proliferation and migration of pulmonary artery smooth muscle cells through the inactivation of PI3K/Akt pathway in pulmonary arterial hypertension.
TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death.
Title: TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death.
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
Title: Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence.
Title: Generation of the short TRIM32 isoform is regulated by Lys 247 acetylation and a PEST sequence.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bardet-Biedl syndrome 11 MedGen: C1859569 OMIM: 615988 GeneReviews: Bardet-Biedl Syndrome Overview	Compare labs
Sarcotubular myopathy MedGen: C0270968 OMIM: 254110 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat expression upregulates TRIM32 expression driving proliferation arrest in human neuronal precursor cells	PubMed
	tat	HIV-1 Tat relocalizes TRIM32 into the nucleus of human neural precursor cells, which causes an increase in ubiquitination of c-Myc	PubMed
	tat	HT2A specifically and precisely binds to the activation domain of HIV-1 Tat (amino acids 1-48), suggesting a role for HT2A in mediating the biological activity of Tat during HIV-1 replication	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G31091 (e-PCR)
- UniSTS:73590

RH18010 (e-PCR)
- UniSTS:3960

RH18537 (e-PCR)
- UniSTS:35731

TRIM32_8005 (e-PCR)
- UniSTS:467950

SHGC-35384 (e-PCR)
- UniSTS:47102

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables Tat protein binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in axon development	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in free ubiquitin chain polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in muscle cell cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine (C-C motif) ligand 20 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with striated muscle myosin thick filament	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM32

Names: 72 kDa Tat-interacting protein; RING-type E3 ubiquitin transferase TRIM32; TAT-interactive protein, 72-KD; tripartite motif-containing protein 32; zinc-finger protein HT2A

NP_001093149.1

EC 2.3.2.27

NP_001365977.1

EC 2.3.2.27

NP_001365978.1

EC 2.3.2.27

NP_001365979.1

EC 2.3.2.27

NP_036342.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011619.1 RefSeqGene

Range

5001..18999

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_211

mRNA and Protein(s)

NM_001099679.2 → NP_001093149.1 E3 ubiquitin-protein ligase TRIM32

See identical proteins and their annotated locations for NP_001093149.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL133284, BC003154, BI544919, BX091494

Consensus CDS

CCDS6817.1

UniProtKB/Swiss-Prot

Q13049, Q9NQP8

Related

ENSP00000363095.1, ENST00000373983.2

Conserved Domains (4) summary

cd14961
Location:362 → 644

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:19 → 65

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:98 → 138

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

pfam15665
Location:143 → 224

FAM184; Family with sequence similarity 184, A and B
NM_001379048.1 → NP_001365977.1 E3 ubiquitin-protein ligase TRIM32

Status: REVIEWED

Source sequence(s)

AL133284

Consensus CDS

CCDS6817.1

UniProtKB/Swiss-Prot

Q13049, Q9NQP8

Conserved Domains (4) summary

cd14961
Location:362 → 644

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:19 → 65

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:98 → 138

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

pfam15665
Location:143 → 224

FAM184; Family with sequence similarity 184, A and B
NM_001379049.1 → NP_001365978.1 E3 ubiquitin-protein ligase TRIM32

Status: REVIEWED

Source sequence(s)

AL133284

Consensus CDS

CCDS6817.1

UniProtKB/Swiss-Prot

Q13049, Q9NQP8

Conserved Domains (4) summary

cd14961
Location:362 → 644

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:19 → 65

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:98 → 138

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

pfam15665
Location:143 → 224

FAM184; Family with sequence similarity 184, A and B
NM_001379050.1 → NP_001365979.1 E3 ubiquitin-protein ligase TRIM32

Status: REVIEWED

Source sequence(s)

AL133284

Consensus CDS

CCDS6817.1

UniProtKB/Swiss-Prot

Q13049, Q9NQP8

Conserved Domains (4) summary

cd14961
Location:362 → 644

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:19 → 65

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:98 → 138

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

pfam15665
Location:143 → 224

FAM184; Family with sequence similarity 184, A and B
NM_012210.4 → NP_036342.2 E3 ubiquitin-protein ligase TRIM32

See identical proteins and their annotated locations for NP_036342.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL133284

Consensus CDS

CCDS6817.1

UniProtKB/Swiss-Prot

Q13049, Q9NQP8

Related

ENSP00000408292.1, ENST00000450136.2

Conserved Domains (4) summary

cd14961
Location:362 → 644

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:19 → 65

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:98 → 138

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

pfam15665
Location:143 → 224

FAM184; Family with sequence similarity 184, A and B