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FGR FGR proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2268, updated on 11-Apr-2024

Summary

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Official Symbol
FGRprovided by HGNC
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3697
See related
Ensembl:ENSG00000000938 MIM:164940; AllianceGenome:HGNC:3697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr
Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See FGR in Genome Data Viewer
Location:
1p35.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (27612064..27635185, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (27453366..27476486, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27938575..27961696, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27849319-27849901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27851813-27852451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27855359-27856073 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27864051-27864652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27869009-27869527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27869528-27870045 Neighboring gene AT-hook DNA binding motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27881926-27882481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27889385-27890112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27907956-27908485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27918399-27918972 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27919547-27920120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27920121-27920694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27922307-27922832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27922833-27923358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27924447-27925402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27925403-27926360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27926361-27927316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27928027-27928623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 523 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 524 Neighboring gene Sharpr-MPRA regulatory region 12291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27939571-27940071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27941009-27941556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27950023-27950844 Neighboring gene Sharpr-MPRA regulatory region 6936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27958413-27958913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 565 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27977663-27978629 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27981022-27981424 Neighboring gene uncharacterized LOC729973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27985747-27986247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27988849-27989364 Neighboring gene long intergenic non-protein coding RNA 2574

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr. Perez I, et al. J Mol Biol, 2022 Jan 30. PMID 34902430, Free PMC Article
  2. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. Weir MC, et al. ACS Chem Biol, 2018 Jun 15. PMID 29763550, Free PMC Article
  3. A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. Joosten M, et al. Mol Oncol, 2016 Oct. PMID 27324824, Free PMC Article
  4. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Hu Y, et al. Nat Genet, 2004 May. PMID 15098032
  5. K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels. De Franceschi L, et al. Am J Physiol Cell Physiol, 2001 Oct. PMID 11546677

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.
    Title: Variants in PSMB9 and FGR differentially affect Parkinson's disease risk in GBA and LRRK2 mutation carriers.
  2. A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
    Title: A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
  3. These studies show that Hck and Fgr expression influences inhibitor sensitivity and the pathway to acquired resistance in Flt3-ITD+ AML.
    Title: Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.
  4. Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation
    Title: The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.
  5. Fgr protein is overexpressed in acute myelogenous leukemia.
    Title: Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.
  6. Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer yielded PTAFR and FGR as the most important hub genes for predicting patient survival.
    Title: Weighted gene co-expression network analysis of gene modules for the prognosis of esophageal cancer.
  7. the Src tyrosine kinase Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance.
    Title: A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
  8. we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule.
    Title: Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
  9. Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells.
    Title: The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.
  10. Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target
    Title: Functional roles of Src and Fgr in ovarian carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) in human B cells PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43153, MGC75096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Fc-gamma receptor I complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables immunoglobulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphotyrosine residue binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
  
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in immune response-regulating cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
  
involved_in negative regulation of natural killer cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in aggresome IDA
Inferred from Direct Assay
more info
  
colocalizes_with cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
c-fgr protooncogene
c-src-2 proto-oncogene
feline Gardner-Rasheed sarcoma viral oncogene homolog
p55-c-fgr protein
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase FGR
v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
NP_001036194.1
NP_001036212.1
NP_005239.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042729.2 → NP_001036194.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates at exon A, resulting in a distinct 5' UTR compared to variant 1. Expression of this variant is upregulated by Epstein-Barr virus. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA960178, M27454
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000363115.3, ENST00000374003.7
    Conserved Domains (3) summary
    cd10367
    Location:140 → 240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80 → 137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267 → 514
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001042747.2 → NP_001036212.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates at exon M3, resulting in a distinct 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BI771758, BQ448283, BX495937, DA952771
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000382126.1, ENST00000399173.5
    Conserved Domains (3) summary
    cd10367
    Location:140 → 240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80 → 137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267 → 514
    PKc_like; Protein Kinases, catalytic domain

  3. NM_005248.3 → NP_005239.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_005239.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates at exon M4 and represents the longest transcript. It is expressed in myelomonocytic cells. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA139476
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    D3DPL7, P09769, Q9UIQ3
    UniProtKB/TrEMBL
    B7Z6W7
    Related
    ENSP00000363117.3, ENST00000374005.8
    Conserved Domains (3) summary
    cd10367
    Location:140 → 240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80 → 137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267 → 514
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    27612064..27635185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    27453366..27476486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09769.2 GenPept UniProtKB/Swiss-Prot:P09769

Gene LinkOut

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