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FGL1 fibrinogen like 1 [ Homo sapiens (human) ]

Gene ID: 2267, updated on 11-Apr-2024

Summary

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Official Symbol
FGL1provided by HGNC
Official Full Name
fibrinogen like 1provided by HGNC
Primary source
HGNC:HGNC:3695
See related
Ensembl:ENSG00000104760 MIM:605776; AllianceGenome:HGNC:3695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPS; HFREP1; HP-041; LFIRE1; LFIRE-1
Summary
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 275.4) See more
Orthologs
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Genomic context

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See FGL1 in Genome Data Viewer
Location:
8p22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17864389..17895538, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (18131895..18183454, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17721898..17753047, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microtubule associated scaffold protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18965 Neighboring gene MTUS1 divergent transcript Neighboring gene uncharacterized LOC124901893 Neighboring gene endogenous retrovirus group K member 25 Env polyprotein-like Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:17769002-17769792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17769793-17770581 Neighboring gene Sharpr-MPRA regulatory region 2266 Neighboring gene uncharacterized LOC124901867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27048 Neighboring gene Sharpr-MPRA regulatory region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27049 Neighboring gene pericentriolar material 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma. Yang C, et al. Front Immunol, 2023. PMID 36993960, Free PMC Article
  2. Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis. Tang XY, et al. Front Immunol, 2022. PMID 36268014, Free PMC Article
  3. Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study. Zhang Y, et al. J Endocrinol Invest, 2022 Nov. PMID 35790683
  4. Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease. Sun XL, et al. World J Gastroenterol, 2021 Sep 21. PMID 34629811, Free PMC Article
  5. Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target. Qian W, et al. J Hematol Oncol, 2021 Sep 15. PMID 34526102, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
    Title: The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer.
  2. Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
    Title: Clinical Significance and Prognostic Value of the Expression of LAG-3 and FGL1 in Esophageal Squamous Cell Carcinoma.
  3. Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
    Title: Fibrinogen-like protein 1 promotes liver-resident memory T-cell exhaustion in hepatocellular carcinoma.
  4. Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
    Title: Dual immunological and proliferative regulation of immune checkpoint FGL1 in lung adenocarcinoma: The pivotal role of the YY1-FGL1-MYH9 axis.
  5. Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
    Title: Serum fibrinogen-like protein 1 as a novel biomarker in polycystic ovary syndrome: a case-control study.
  6. Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
    Title: Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
  7. Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
    Title: Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.
  8. Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
    Title: Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease.
  9. Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
    Title: Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.
  10. Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function.
    Title: Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hepatocyte proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibrinogen-like protein 1
Names
hepassocin
hepatocellular carcinoma-related sequence
hepatocyte-derived fibrinogen-related protein 1
liver fibrinogen-related protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004467.4 → NP_004458.3  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_004458.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) appears to be the predominantly expressed transcript. It lacks an exon in the 5' UTR and has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AC087273, AF042354, BG618053, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
    Related
    ENSP00000401952.1, ENST00000427924.5
    Conserved Domains (1) summary
    cd00087
    Location:78 → 304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

  2. NM_147203.2 → NP_671736.2  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_671736.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AF042354, BC007047, BG567956
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
    Related
    ENSP00000371262.2, ENST00000381840.5
    Conserved Domains (1) summary
    cd00087
    Location:78 → 304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

  3. NM_201552.1 → NP_963846.1  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_963846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate exon at the 5' end compared to the longest variant (4). All four variants encode the same protein.
    Source sequence(s)
    AF042354, BC007047, BG566131, BG618053, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
    Related
    ENSP00000371263.2, ENST00000381841.4
    Conserved Domains (1) summary
    cd00087
    Location:78 → 304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

  4. NM_201553.1 → NP_963847.1  fibrinogen-like protein 1 precursor

    See identical proteins and their annotated locations for NP_963847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AF042354, BG565379, BG567956, D87342
    Consensus CDS
    CCDS6004.1
    UniProtKB/Swiss-Prot
    A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6
    Related
    ENSP00000381131.1, ENST00000398054.5
    Conserved Domains (1) summary
    cd00087
    Location:78 → 304
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    17864389..17895538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421577.1 → XP_047277533.1  fibrinogen-like protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    18131895..18183454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360131.1 → XP_054216106.1  fibrinogen-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A6NKU4, Q08830, Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6

  2. XM_054360132.1 → XP_054216107.1  fibrinogen-like protein 1 isoform X1

RNA

  1. XR_008487822.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08830.3 GenPept UniProtKB/Swiss-Prot:Q08830

Gene LinkOut

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