FGF11 fibroblast growth factor 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGF11provided by HGNC
Official Full Name: fibroblast growth factor 11provided by HGNC
Primary source: HGNC:HGNC:3667
See related: Ensembl:ENSG00000161958 MIM:601514; AllianceGenome:HGNC:3667
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FHF3; FHF-3; FGF-11
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression: Broad expression in adrenal (RPKM 9.9), skin (RPKM 7.0) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7438298..7444937)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7342353..7348996)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7341617..7348256)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene Expression Through FXRalpha Suppression.
Title: Fibroblast Growth Factor 11 Inhibits Hepatitis B Virus Gene Expression Through FXRα Suppression.
Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity.
Title: Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity.
Hypoxia promotes thyroid cancer progression through HIF1alpha/FGF11 feedback loop.
Title: Hypoxia promotes thyroid cancer progression through HIF1α/FGF11 feedback loop.
Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway.
Title: Fibroblast growth factor 11 (FGF11) promotes non-small cell lung cancer (NSCLC) progression by regulating hypoxia signaling pathway.
Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations.
Title: Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations.
FGF11 indirectly controls the expression of PPARgamma through modifying the expression of multiple PPARgamma regulators, thereby mediating adipogenesis.
Title: FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.
Endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. From a mechanistic standpoint, miR-342-3p promoted the transactivation of fibroblast growth factor 11 (FGF11) by directly targeting its 3' untranslated regions (3'UTRs).
Title: T2DM inhibition of endothelial miR-342-3p facilitates angiogenic dysfunction via repression of FGF11 signaling.
FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents
Title: Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone.
Exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in nasopharyngeal carcinoma (NPC).
Title: Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma.
these results suggest a cross-regulation between HIF-1alpha and FGF11, through which hypoxia-induced FGF11 reinforces hypoxia responses by enhancing the stability of HIF-1alpha.
Title: FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf11 (e-PCR), detects polymorphism
- UniSTS:507914

Fgf11 (e-PCR), detects polymorphism
- UniSTS:546575

Fgf11 (e-PCR), detects polymorphism
- UniSTS:516627

FGF11_2203 (e-PCR)
- UniSTS:280669

RH78385 (e-PCR)
- UniSTS:85126

G30483 (e-PCR)
- UniSTS:67493

D17S1968 (e-PCR)
- UniSTS:11456

Fgf11 (e-PCR), detects polymorphism
- UniSTS:258257

STS-W57641 (e-PCR)
- UniSTS:27106

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 11

Names: fibroblast growth factor homologous factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303460.2 → NP_001290389.1 fibroblast growth factor 11 isoform 2

See identical proteins and their annotated locations for NP_001290389.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC113189

UniProtKB/TrEMBL

B7Z1C3

Conserved Domains (1) summary

smart00442
Location:10 → 140

FGF; Acidic and basic fibroblast growth factor family
NM_004112.4 → NP_004103.1 fibroblast growth factor 11 isoform 1

See identical proteins and their annotated locations for NP_004103.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC113189

Consensus CDS

CCDS11105.1

UniProtKB/Swiss-Prot

Q2YDX8, Q92914

UniProtKB/TrEMBL

A0A7U3JVZ5

Related

ENSP00000293829.4, ENST00000293829.9

Conserved Domains (1) summary

smart00442
Location:69 → 199

FGF; Acidic and basic fibroblast growth factor family

RNA

NR_130156.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate 5' terminal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AC113189

Related

ENST00000575082.5