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FCGR1BP Fc gamma receptor Ib, pseudogene [ Homo sapiens (human) ]

Gene ID: 2210, updated on 11-Apr-2024

Summary

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Official Symbol
FCGR1BPprovided by HGNC
Official Full Name
Fc gamma receptor Ib, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:3614
See related
Ensembl:ENSG00000291135 MIM:601502; AllianceGenome:HGNC:3614
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD34; FCG1; FcRI; CD64b; FCGR1; IGFR1; IGFRB; FCGR1B; FcgammaRIa
Summary
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene likely encodes a non-functional protein that is not detectable at the cell surface and binds ligand with low affinity. [provided by RefSeq, Nov 2019]
Expression
Biased expression in appendix (RPKM 11.2), placenta (RPKM 7.0) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
1p11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (121087345..121097161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (121096728..121106544)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120926128..120935944, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PDE4DIP pseudogene 4 Neighboring gene tRNA-Asn (anticodon GTT) 27-1 Neighboring gene ubiquitin-conjugating enzyme E2 D4-like Neighboring gene H3 histone pseudogene 4 Neighboring gene uncharacterized LOC100996318 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1254 Neighboring gene H2B histone pseudogene 1 Neighboring gene ribosomal protein L22 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Diagnostic value of FCGR1B gene transcription level in active tuberculosis]. Liu YH, et al. Zhonghua Jie He He Hu Xi Za Zhi, 2022 Apr 12. PMID 35381635
  2. Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity. Shimizu T, et al. J Clin Rheumatol, 2020 Mar. PMID 32073518
  3. The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64. Neuteboom RF, et al. Mult Scler, 2011 Apr. PMID 21135020
  4. [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China]. Tang Y, et al. Zhonghua Jie He He Hu Xi Za Zhi, 2001 Mar. PMID 11802953
  5. The alternatively spliced CD64 transcript FcgammaRIb2 does not specify a surface-expressed isoform. van Vugt MJ, et al. Eur J Immunol, 1999 Jan. PMID 9933095

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Diagnostic value of FCGR1B gene transcription level in active tuberculosis].
    Title: [Diagnostic value of FCGR1B gene transcription level in active tuberculosis].
  2. Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity.
    Title: Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity.
  3. The increased CD64 expression during pregnancy in patients with multiple sclerosis is indicative of enhanced innate immune functions.
    Title: The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64.
  4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: [Study on mutations of beta chain of high-affinity IgE receptor gene in people of Han nationality of southern China].
  6. Fcgamma receptor I Ab and Fcgamma receptor I play an important role in the regulation of alopecia areata (AA), are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.
    Title: Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • Fc fragment of IgG receptor Ib
  • Fc fragment of IgG, high affinity Ib, receptor (CD64)
  • Fc gamma receptor Ib
  • Fc-gamma RI
  • Fc-gamma RIA
  • Fc-gamma receptor I B2
  • High affinity immunoglobulin gamma Fc receptor I
  • IgG Fc receptor I
  • fc-gamma RIB
  • fcRIB
  • hFcgammaRIB
  • high affinity immunoglobulin gamma Fc receptor IB
  • igG Fc receptor IB

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
  
enables IgG receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables immunoglobulin receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in antibody-dependent cellular cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_045213.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC244453

  2. NR_164758.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
    Related
    ENST00000369383.9

  3. NR_164759.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
    Related
    ENST00000369384.10

  4. NR_164760.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC244453
    Related
    ENST00000471609.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    121087345..121097161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    121096728..121106544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_030319.1: Suppressed sequence

    Description
    NG_030319.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  2. NM_001004340.4: Suppressed sequence

    Description
    NM_001004340.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  3. NM_001017986.4: Suppressed sequence

    Description
    NM_001017986.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  4. NM_001244910.1: Suppressed sequence

    Description
    NM_001244910.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92637.1 GenPept UniProtKB/Swiss-Prot:Q92637

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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