ERBB4 erb-b2 receptor tyrosine kinase 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ERBB4provided by HGNC
Official Full Name: erb-b2 receptor tyrosine kinase 4provided by HGNC
Primary source: HGNC:HGNC:3432
See related: Ensembl:ENSG00000178568 MIM:600543; AllianceGenome:HGNC:3432
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HER4; ALS19; p180erbB4
Summary: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Biased expression in kidney (RPKM 3.0), brain (RPKM 2.7) and 8 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q34

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (211375717..212538802, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (211856201..213019445, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (212240442..213403526, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.
Title: Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.
ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.
Title: ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.
Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.
Title: Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.
MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.
Title: MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.
NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.
Title: NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.
miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.
Title: miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.
Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.
Title: Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.
Cancer regulator EGFR-ErbB4 heterodimer is stabilized through glycans at the dimeric interface.
Title: Cancer regulator EGFR-ErbB4 heterodimer is stabilized through glycans at the dimeric interface.
The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.
Title: The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.
Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-kappaB pathway.
Title: Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-κB pathway.

Submit: New GeneRIF Correction See all GeneRIFs (275)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Amyotrophic lateral sclerosis type 19 MedGen: C3715155 OMIM: 615515 GeneReviews: Amyotrophic Lateral Sclerosis Overview	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of coronary artery calcification among African Americans, a meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of the five-factor model of personality in young Korean women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide interaction studies reveal sex-specific asthma risk alleles. EBI GWAS Catalog EBI GWAS CatalogPubMed
New susceptibility loci associated with kidney disease in type 1 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-153780 (e-PCR)
- UniSTS:177934

WI-21559 (e-PCR)
- UniSTS:24091

D2S1749 (e-PCR)
- UniSTS:58949

AU049543 (e-PCR)
- UniSTS:145990

SHGC-85721 (e-PCR)
- UniSTS:103752

SHGC-9274 (e-PCR)
- UniSTS:1102

SHGC-144718 (e-PCR)
- UniSTS:172375

AFMa052yb9 (e-PCR)
- UniSTS:34394

SHGC-82395 (e-PCR)
- UniSTS:104540

G19847 (e-PCR)
- UniSTS:40542

D2S2712 (e-PCR)
- UniSTS:20322

A005E44 (e-PCR)
- UniSTS:23414

RH120271 (e-PCR)
- UniSTS:132727

SHGC-83780 (e-PCR)
- UniSTS:100987

RH119484 (e-PCR)
- UniSTS:133526

G65476 (e-PCR)
- UniSTS:166564

G16508 (e-PCR)
- UniSTS:433

RH15943 (e-PCR)
- UniSTS:19634

SHGC-80807 (e-PCR)
- UniSTS:102326

D2S1702E (e-PCR)
- UniSTS:150731

G63819 (e-PCR)
- UniSTS:139472

G43306 (e-PCR)
- UniSTS:94932

RH47938 (e-PCR)
- UniSTS:70871

RH120744 (e-PCR)
- UniSTS:132826

D2S371 (e-PCR), detects polymorphism
- UniSTS:11482

G54596 (e-PCR)
- UniSTS:117732

G59782 (e-PCR)
- UniSTS:136935

D2S371 (e-PCR), detects polymorphism
- UniSTS:10992

SHGC-79806 (e-PCR)
- UniSTS:101104

RH68995 (e-PCR)
- UniSTS:9460

SHGC-80076 (e-PCR)
- UniSTS:102133

RH45906 (e-PCR)
- UniSTS:62966

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GABA receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuregulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB2-ERBB4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4-ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle tissue regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cellular response to epidermal growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in central nervous system morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic pattern specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity involved in nephron morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb interneuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in basal plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor tyrosine-protein kinase erbB-4

Names: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; human epidermal growth factor receptor 4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

NP_001036064.1

EC 2.7.10.1

NP_005226.1

EC 2.7.10.1

XP_005246433.1

EC 2.7.10.1

XP_005246434.1

EC 2.7.10.1

XP_006712427.1

EC 2.7.10.1

XP_016859066.1

EC 2.7.10.1

XP_016859067.1

EC 2.7.10.1

XP_016859068.1

EC 2.7.10.1

XP_016859069.1

EC 2.7.10.1

XP_016859070.1

EC 2.7.10.1

XP_016859071.1

EC 2.7.10.1

XP_054196992.1

EC 2.7.10.1

XP_054196993.1

EC 2.7.10.1

XP_054196994.1

EC 2.7.10.1

XP_054196995.1

EC 2.7.10.1

XP_054196996.1

EC 2.7.10.1

XP_054196997.1

EC 2.7.10.1

XP_054196998.1

EC 2.7.10.1

XP_054196999.1

EC 2.7.10.1

XP_054197000.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011805.2 RefSeqGene

Range

4827..1167912

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042599.1 → NP_001036064.1 receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2 precursor

See identical proteins and their annotated locations for NP_001036064.1

Status: REVIEWED

Description

Transcript Variant: This variant (JM-a/CYT-2) lacks an alternate in-frame exon, compared to variant JM-a/CYT-1, resulting in a shorter protein (isoform JM-a/CYT-2) that lacks the phosphotidylinositol-3 kinase binding site, compared to isoform JM-a/CYT-1.

Source sequence(s)

AB209697, AC012069, AI793060, BC112199, BQ015804, L07868

Consensus CDS

CCDS42811.1

Related

ENSP00000403204.1, ENST00000436443.5

Conserved Domains (5) summary

cd05110
Location:710 → 1012

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:642 → 685

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
NM_005235.3 → NP_005226.1 receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-1 precursor

See identical proteins and their annotated locations for NP_005226.1

Status: REVIEWED

Description

Transcript Variant: This variant (JM-a/CYT-1) represents the longer transcript and encodes the longer isoform (JM-a/CYT-1).

Source sequence(s)

AC012069, AC096765, AI793060, BQ015804, CR627023, L07868

Consensus CDS

CCDS2394.1

UniProtKB/Swiss-Prot

B7ZLD7, B7ZLE2, B7ZLE3, Q15303, Q2M1W1, Q59EW4

Related

ENSP00000342235.4, ENST00000342788.9

Conserved Domains (5) summary

cd05110
Location:710 → 1012

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:642 → 685

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

211375717..212538802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005246377.4 → XP_005246434.1 receptor tyrosine-protein kinase erbB-4 isoform X8

See identical proteins and their annotated locations for XP_005246434.1

Related

ENSP00000260943.7, ENST00000260943.11

Conserved Domains (5) summary

cd05110
Location:700 → 1002

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:632 → 675

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
XM_005246376.4 → XP_005246433.1 receptor tyrosine-protein kinase erbB-4 isoform X7

See identical proteins and their annotated locations for XP_005246433.1

Conserved Domains (5) summary

cd05110
Location:700 → 1002

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:632 → 675

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
XM_006712364.4 → XP_006712427.1 receptor tyrosine-protein kinase erbB-4 isoform X5

Conserved Domains (8) summary

cd05110
Location:725 → 1027

PTKc_HER4; Catalytic domain of the Protein Tyrosine Kinase, HER4

cd12092
Location:657 → 700

TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase

smart00261
Location:549 → 596

FU; Furin-like repeats

cd00064
Location:229 → 274

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:186 → 332

Furin-like; Furin-like cysteine rich region

pfam01030
Location:55 → 167

Recep_L_domain; Receptor L domain

pfam07714
Location:733 → 989

Pkinase_Tyr; Protein tyrosine kinase

pfam14843
Location:502 → 634

GF_recep_IV; Growth factor receptor domain IV
XM_017003581.3 → XP_016859070.1 receptor tyrosine-protein kinase erbB-4 isoform X6
XM_017003578.3 → XP_016859067.1 receptor tyrosine-protein kinase erbB-4 isoform X2
XM_017003580.3 → XP_016859069.1 receptor tyrosine-protein kinase erbB-4 isoform X4
XM_017003579.3 → XP_016859068.1 receptor tyrosine-protein kinase erbB-4 isoform X3
XM_017003577.3 → XP_016859066.1 receptor tyrosine-protein kinase erbB-4 isoform X1
XM_017003582.2 → XP_016859071.1 receptor tyrosine-protein kinase erbB-4 isoform X9

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

211856201..213019445 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054341024.1 → XP_054196999.1 receptor tyrosine-protein kinase erbB-4 isoform X8
XM_054341023.1 → XP_054196998.1 receptor tyrosine-protein kinase erbB-4 isoform X7
XM_054341021.1 → XP_054196996.1 receptor tyrosine-protein kinase erbB-4 isoform X5
XM_054341022.1 → XP_054196997.1 receptor tyrosine-protein kinase erbB-4 isoform X6
XM_054341018.1 → XP_054196993.1 receptor tyrosine-protein kinase erbB-4 isoform X2
XM_054341020.1 → XP_054196995.1 receptor tyrosine-protein kinase erbB-4 isoform X4
XM_054341019.1 → XP_054196994.1 receptor tyrosine-protein kinase erbB-4 isoform X3
XM_054341017.1 → XP_054196992.1 receptor tyrosine-protein kinase erbB-4 isoform X1
XM_054341025.1 → XP_054197000.1 receptor tyrosine-protein kinase erbB-4 isoform X9