U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SENP5 SUMO specific peptidase 5 [ Homo sapiens (human) ]

Gene ID: 205564, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
SENP5provided by HGNC
Official Full Name
SUMO specific peptidase 5provided by HGNC
Primary source
HGNC:HGNC:28407
See related
Ensembl:ENSG00000119231 MIM:612845; AllianceGenome:HGNC:28407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in testis (RPKM 8.4), brain (RPKM 6.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SENP5 in Genome Data Viewer
Location:
3q29
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196867920..196934714)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199593622..199660765)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196594791..196661585)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 89, pseudogene Neighboring gene p21 (RAC1) activated kinase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196499493-196499749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:196513771-196514477 Neighboring gene RNA, U6 small nuclear 42, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr3:196568870-196569024 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:196595799-196596300 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:196625459-196625966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196668731-196669404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:196669405-196670078 Neighboring gene NCBP2 antisense RNA 1 Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sentrin/small ubiquitin-like modifier-specific protease 5 protects oral cancer cells from oxidative stress-induced apoptosis. Cheng Y, et al. Mol Med Rep, 2015 Aug. PMID 25901414
  2. SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade. Cashman R, et al. Oncotarget, 2014 Feb 28. PMID 24658161, Free PMC Article
  3. Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Ding X, et al. Oncol Rep, 2008 Nov. PMID 18949399
  4. SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A. Yu B, et al. J Cell Sci, 2021 Jul 1. PMID 34313310
  5. The SUMO-specific protease SENP5 is required for cell division. Di Bacco A, et al. Mol Cell Biol, 2006 Jun. PMID 16738315, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.
    Title: SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation.
  2. SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
    Title: SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
  3. Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.
    Title: Zinc deficiency induces abnormal development of the myocardium by promoting SENP5 overexpression.
  4. Results from a study on gene expression variability markers in early-stage human embryos shows that SENP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage.
    Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
  5. Mild oxidative stress stabilized the SENP5 protein in the oral squamous cell carcinoma cells, and only the combination of SENP5 silencing and H2O2 application led to mitochondria fragmentation and a significant increase in cell apoptosis.
    Title: Sentrin/small ubiquitin-like modifier-specific protease 5 protects oral cancer cells from oxidative stress-induced apoptosis.
  6. Low expression of SENP5 is associated with good prognosis among breast cancer patients.
    Title: SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade.
  7. altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC.
    Title: Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation.
  8. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
    Title: Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
  9. Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis.
    Title: The SUMO-specific protease SENP5 is required for cell division.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of SUMO1/sentrin specific peptidase 5 (SENP5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ42398, MGC27076, DKFZp564O1016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
 PubMed 
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation TAS
Traceable Author Statement
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sentrin-specific protease 5
Names
SUMO1/sentrin specific peptidase 5
SUMO1/sentrin specific protease 5
sentrin/SUMO-specific protease SENP5
NP_001294974.1
NP_689912.2
XP_005269367.1
XP_047303630.1
XP_047303631.1
XP_047303632.1
XP_054201633.1
XP_054201634.1
XP_054201635.1
XP_054201636.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308045.2 → NP_001294974.1  sentrin-specific protease 5 isoform 2

    See identical proteins and their annotated locations for NP_001294974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC011322, AK302305, AK313764, AL049229
    Consensus CDS
    CCDS77876.1
    UniProtKB/TrEMBL
    B2R9F5
    Related
    ENSP00000390231.2, ENST00000445299.6
    Conserved Domains (1) summary
    cl23802
    Location:581 → 707
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_152699.5 → NP_689912.2  sentrin-specific protease 5 isoform 1

    See identical proteins and their annotated locations for NP_689912.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011322, AL049229, BC030705, DC399261
    Consensus CDS
    CCDS3322.1
    UniProtKB/Swiss-Prot
    B4DY82, Q96HI0, Q96SA5
    UniProtKB/TrEMBL
    B2R9F5
    Related
    ENSP00000327197.5, ENST00000323460.10
    Conserved Domains (1) summary
    pfam02902
    Location:581 → 753
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    196867920..196934714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269310.4 → XP_005269367.1  sentrin-specific protease 5 isoform X1

    UniProtKB/TrEMBL
    B2R9F5
    Conserved Domains (1) summary
    pfam02902
    Location:581 → 725
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. XM_047447675.1 → XP_047303631.1  sentrin-specific protease 5 isoform X3

  3. XM_047447676.1 → XP_047303632.1  sentrin-specific protease 5 isoform X4

  4. XM_047447674.1 → XP_047303630.1  sentrin-specific protease 5 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    199593622..199660765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345658.1 → XP_054201633.1  sentrin-specific protease 5 isoform X1

  2. XM_054345660.1 → XP_054201635.1  sentrin-specific protease 5 isoform X3

  3. XM_054345661.1 → XP_054201636.1  sentrin-specific protease 5 isoform X4

  4. XM_054345659.1 → XP_054201634.1  sentrin-specific protease 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96HI0.3 GenPept UniProtKB/Swiss-Prot:Q96HI0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous