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ADCK5 aarF domain containing kinase 5 [ Homo sapiens (human) ]

Gene ID: 203054, updated on 5-Mar-2024

Summary

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Official Symbol
ADCK5provided by HGNC
Official Full Name
aarF domain containing kinase 5provided by HGNC
Primary source
HGNC:HGNC:21738
See related
Ensembl:ENSG00000173137 AllianceGenome:HGNC:21738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 5.3), small intestine (RPKM 4.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144373088..144393242)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145542413..145562879)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145597736..145618457)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145583746-145584281 Neighboring gene solute carrier family 52 member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145589246-145589414 Neighboring gene uncharacterized LOC101928902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:145593027-145593528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145595436-145595936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145613649-145614150 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145619396-145619557 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145620910-145621123 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene microRNA 939 Neighboring gene microRNA 1234

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway. Qiu M, et al. Exp Cell Res, 2020 Jul 1. PMID 32277958
  2. DNA sequence and analysis of human chromosome 8. Nusbaum C, et al. Nature, 2006 Jan 19. PMID 16421571
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Wang T, et al. Neurobiol Aging, 2015 Jan. PMID 25192599
  4. NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Chen W, et al. Cell Death Dis, 2020 Jul 14. PMID 32665550, Free PMC Article
  5. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
    Title: aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35454, MGC126708

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized aarF domain-containing protein kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174922.5 → NP_777582.4  uncharacterized aarF domain-containing protein kinase 5

    See identical proteins and their annotated locations for NP_777582.4

    Status: VALIDATED

    Source sequence(s)
    BC064345, BC101659, HY037845
    Consensus CDS
    CCDS34965.2
    UniProtKB/Swiss-Prot
    B3KS46, Q3MIX3, Q5U4P1, Q6P2S4, Q8N5V3
    Related
    ENSP00000310547.6, ENST00000308860.11
    Conserved Domains (1) summary
    cd13969
    Location:169 → 409
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144373088..144393242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013174.2 → XP_016868663.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    Conserved Domains (2) summary
    COG0661
    Location:61 → 341
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:102 → 342
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  2. XM_011516907.4 → XP_011515209.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

    Conserved Domains (2) summary
    COG0661
    Location:202 → 482
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:243 → 483
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  3. XM_047421456.1 → XP_047277412.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

  4. XM_011516909.2 → XP_011515211.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

    See identical proteins and their annotated locations for XP_011515211.1

    Conserved Domains (2) summary
    COG0661
    Location:61 → 341
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:102 → 342
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  5. XM_011516910.2 → XP_011515212.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    See identical proteins and their annotated locations for XP_011515212.1

    Conserved Domains (2) summary
    COG0661
    Location:6 → 301
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:62 → 302
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  6. XM_006716527.3 → XP_006716590.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

    See identical proteins and their annotated locations for XP_006716590.1

    Conserved Domains (2) summary
    COG0661
    Location:6 → 301
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:62 → 302
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p14 PATCHES

    Range
    104365..123845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332186.1 → XP_054188161.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

  2. XM_054332181.1 → XP_054188156.1  uncharacterized aarF domain-containing protein kinase 5 isoform X1

  3. XM_054332183.1 → XP_054188158.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

  4. XM_054332182.1 → XP_054188157.1  uncharacterized aarF domain-containing protein kinase 5 isoform X2

  5. XM_054332185.1 → XP_054188160.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

  6. XM_054332184.1 → XP_054188159.1  uncharacterized aarF domain-containing protein kinase 5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145542413..145562879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359953.1 → XP_054215928.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

  2. XM_054359948.1 → XP_054215923.1  uncharacterized aarF domain-containing protein kinase 5 isoform X5

  3. XM_054359950.1 → XP_054215925.1  uncharacterized aarF domain-containing protein kinase 5 isoform X3

  4. XM_054359949.1 → XP_054215924.1  uncharacterized aarF domain-containing protein kinase 5 isoform X6

  5. XM_054359952.1 → XP_054215927.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7

  6. XM_054359951.1 → XP_054215926.1  uncharacterized aarF domain-containing protein kinase 5 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MIX3.3 GenPept UniProtKB/Swiss-Prot:Q3MIX3

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