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DTNA dystrobrevin alpha [ Homo sapiens (human) ]

Gene ID: 1837, updated on 3-Apr-2024

Summary

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Official Symbol
DTNAprovided by HGNC
Official Full Name
dystrobrevin alphaprovided by HGNC
Primary source
HGNC:HGNC:3057
See related
Ensembl:ENSG00000134769 MIM:601239; AllianceGenome:HGNC:3057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTN; DRP3; DTN-A; LVNC1; D18S892E
Summary
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 27.5), heart (RPKM 10.7) and 10 other tissues See more
Orthologs
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Genomic context

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See DTNA in Genome Data Viewer
Location:
18q12.1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (34493312..34891844)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (34685119..35083714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32073276..32471808)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4 Neighboring gene uncharacterized LOC124904279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:31802111-31802612 Neighboring gene uncharacterized LOC124904280 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:31864116-31864338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9393 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32128465-32129021 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32129022-32129577 Neighboring gene NANOG hESC enhancer GRCh37_chr18:32142500-32143095 Neighboring gene ribosomal protein L10a pseudogene 13 Neighboring gene uncharacterized LOC124904281 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:32239357-32239860 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:32239861-32240364 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32427354-32428159 Neighboring gene Sharpr-MPRA regulatory region 11937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13217 Neighboring gene uncharacterized LOC105372061 Neighboring gene Sharpr-MPRA regulatory region 7107 Neighboring gene Sharpr-MPRA regulatory region 2105 Neighboring gene uncharacterized LOC124904282

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Variants in DTNA cause a mild, dominantly inherited muscular dystrophy. Nascimento A, et al. Acta Neuropathol, 2023 Apr. PMID 36799992, Free PMC Article
  2. Whole-exome sequencing reveals a rare missense variant in DTNA in an Iranian pedigree with early-onset atrial fibrillation. Malakootian M, et al. BMC Cardiovasc Disord, 2022 Feb 11. PMID 35148685, Free PMC Article
  3. Localization of α-Dystrobrevin in Cajal Bodies and Nucleoli: A New Role for α-Dystrobrevin in the Structure/Stability of the Nucleolus. Hernández-Ibarra JA, et al. J Cell Biochem, 2015 Dec. PMID 25959029
  4. Alpha-Dystrobrevin and its associated proteins in human promyelocytic leukemia cells induced to apoptosis. Navakauskienė R, et al. J Proteomics, 2012 Jun 18. PMID 22507200
  5. Aberrantly spliced alpha-dystrobrevin alters alpha-syntrophin binding in myotonic dystrophy type 1. Nakamori M, et al. Neurology, 2008 Feb 26. PMID 18299519

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in DTNA cause a mild, dominantly inherited muscular dystrophy.
    Title: Variants in DTNA cause a mild, dominantly inherited muscular dystrophy.
  2. Oncogenic microRNA-301b regulates tumor repressor dystrobrevin alpha to facilitate cell growth, invasion and migration in esophageal cancer.
    Title: Oncogenic microRNA-301b regulates tumor repressor dystrobrevin alpha to facilitate cell growth, invasion and migration in esophageal cancer.
  3. Whole-exome sequencing reveals a rare missense variant in DTNA in an Iranian pedigree with early-onset atrial fibrillation.
    Title: Whole-exome sequencing reveals a rare missense variant in DTNA in an Iranian pedigree with early-onset atrial fibrillation.
  4. DTNA promotes HBV-induced hepatocellular carcinoma progression by activating STAT3 and regulating TGFbeta1 and P53 signaling.
    Title: DTNA promotes HBV-induced hepatocellular carcinoma progression by activating STAT3 and regulating TGFβ1 and P53 signaling.
  5. Report left ventricular non-compaction associated with Barth Syndrome due to triple mutations in TAZ, DTNA, and SDHA genes in multiple members of one family.
    Title: Barth syndrome associated with triple mutation.
  6. we show for the first time localization of alpha-DB2 in nucleoli and Cajal bodies and provide evidence that a-DB2 is involved in the structure of nucleoli and might modulate nucleolar functions
    Title: Localization of α-Dystrobrevin in Cajal Bodies and Nucleoli: A New Role for α-Dystrobrevin in the Structure/Stability of the Nucleolus.
  7. our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD.
    Title: Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere's disease.
  8. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
    Title: Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
  9. apoptosis-induction in HL-60 cells involves not only classical markers of apoptosis but also a network alpha-DB-associated proteins at the cell membrane, the cytoplasm and nucleus, affecting key cellular transport processes and cellular structure.
    Title: Alpha-Dystrobrevin and its associated proteins in human promyelocytic leukemia cells induced to apoptosis.
  10. Results suggest that alpha-dystrobrevin isoforms play a central role in cytoskeleton reorganization via their multiple interactions with actin and actin-associating proteins.
    Title: α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Left ventricular noncompaction 1
MedGen: C1858725 OMIM: 604169 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of dystrobrevin, alpha (DTNA) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ96209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuromuscular synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in striated muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dystrobrevin alpha
Names
dystrophin-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009201.1 RefSeqGene

    Range
    5023..403555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_756

mRNA and Protein(s)

  1. NM_001128175.2 → NP_001121647.1  dystrobrevin alpha isoform 9

    See identical proteins and their annotated locations for NP_001121647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal coding exon and multiple exons from the 3' end, and contains an alternate 3' exon, compared to variant 1. The resulting isoform (9) lacks an internal segment and has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AI368045, BC005300, DA197970
    Consensus CDS
    CCDS56060.1
    UniProtKB/TrEMBL
    A0A7P0TAN3
    Related
    ENSP00000451516.2, ENST00000554864.7
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  2. NM_001198938.2 → NP_001185867.1  dystrobrevin alpha isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the CDS and 3' UTR compared to variant 1. The resulting isoform (10) is shorter; it lacks two internal segments and has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB209102, AK308410, BC005300, BC033969, BX103860, CF457303, DA197970
    Consensus CDS
    CCDS59312.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000470152.1, ENST00000598334.5
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  3. NM_001198939.2 → NP_001185868.1  dystrobrevin alpha isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the CDS compared to variant 1. The resulting isoform (11) lacks two internal segments but has an extra segment in a downstream region, compared to isoform 1.
    Source sequence(s)
    AC068506, AL833285, BC005300, DA197970
    Consensus CDS
    CCDS56061.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000382072.5, ENST00000399121.9
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam11068
    Location:414 → 502
    YlqD; YlqD protein

  4. NM_001198940.2 → NP_001185869.1  dystrobrevin alpha isoform 12

    See identical proteins and their annotated locations for NP_001185869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the CDS compared to variant 1. The resulting isoform (12) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AB209102, AC068506, DA197970
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000473078.1, ENST00000595022.5
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  5. NM_001198941.2 → NP_001185870.1  dystrobrevin alpha isoform 13

    See identical proteins and their annotated locations for NP_001185870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the CDS, lacks multiple exons from the 3' UTR and contains an alternate 3' exon compared to variant 1. The resulting isoform (13) lacks two internal segments and has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC068506, AK291156
    Consensus CDS
    CCDS59310.1
    UniProtKB/TrEMBL
    A0A7P0T8J4
    Related
    ENSP00000473119.1, ENST00000597599.5
    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  6. NM_001198942.1 → NP_001185871.1  dystrobrevin alpha isoform 14

    See identical proteins and their annotated locations for NP_001185871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks multiple exons from the 5' end, contains an alternate 5' exon, and differs in the CDS compared to variant 1. The resulting isoform (14) has a much shorter N-terminus, lacks an internal segment in one region and contains an extra segment in a different region, compared to isoform 1.
    Source sequence(s)
    AC068506, AK295732, DN991561
    Consensus CDS
    CCDS56062.1
    UniProtKB/TrEMBL
    A0A804HHU2
    Related
    ENSP00000269192.7, ENST00000269192.11
    Conserved Domains (1) summary
    pfam13874
    Location:179 → 262
    Nup54; Nucleoporin complex subunit 54

  7. NM_001198943.1 → NP_001185872.1  dystrobrevin alpha isoform 15

    See identical proteins and their annotated locations for NP_001185872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) lacks multiple exons from the 5' end, contains an alternate 5' UTR, and differs in the CDS compared to variant 1. The resulting isoform (15) has a much shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AK296450
    UniProtKB/TrEMBL
    A0A7P0TBG1, B7Z3X3
    Related
    ENSP00000470247.1, ENST00000601125.5
    Conserved Domains (2) summary
    cd02334
    Location:1 → 39
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam13874
    Location:160 → 243
    Nup54; Nucleoporin complex subunit 54

  8. NM_001198944.1 → NP_001185873.1  dystrobrevin alpha isoform 16

    See identical proteins and their annotated locations for NP_001185873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks multiple exons from the 5' end, contains an alternate 5' exon, and differs in the CDS compared to variant 1. The resulting isoform (16) has a much shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AK295789, DN991561
    Consensus CDS
    CCDS56063.1
    UniProtKB/TrEMBL
    M0QZ28
    Related
    ENSP00000452255.2, ENST00000556414.7
    Conserved Domains (1) summary
    pfam13874
    Location:122 → 205
    Nup54; Nucleoporin complex subunit 54

  9. NM_001198945.2 → NP_001185874.1  dystrobrevin alpha isoform 17

    See identical proteins and their annotated locations for NP_001185874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks multiple exons in the middle region and from the 3' end, and contains an alternate 3' exon compared to variant 1. The resulting isoform (17) lacks a large internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC068506, AK294746, R45531
    Consensus CDS
    CCDS59313.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000469121.1, ENST00000596745.5
    Conserved Domains (2) summary
    cd16249
    Location:54 → 202
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl28419
    Location:226 → 296
    SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  10. NM_001386753.1 → NP_001373682.1  dystrobrevin alpha isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS59312.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  11. NM_001386754.1 → NP_001373683.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  12. NM_001386755.1 → NP_001373684.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Related
    ENSP00000507106.1, ENST00000684266.1
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  13. NM_001386756.1 → NP_001373685.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC013290, AC022601, AC068506
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  14. NM_001386757.1 → NP_001373686.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC013290, AC022601, AC068506
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Related
    ENSP00000506757.1, ENST00000684377.1
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  15. NM_001386758.1 → NP_001373687.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  16. NM_001386759.1 → NP_001373688.1  dystrobrevin alpha isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS92449.1
    UniProtKB/TrEMBL
    A0A7P0Z4D7, A0A804HHT6
    Related
    ENSP00000505718.1, ENST00000680822.1
    Conserved Domains (3) summary
    PRK00286
    Location:369 → 541
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  17. NM_001386760.1 → NP_001373689.1  dystrobrevin alpha isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    UniProtKB/TrEMBL
    A0A7P0T8Y5
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:437 → 627
    MS_channel; Mechanosensitive ion channel

  18. NM_001386761.1 → NP_001373690.1  dystrobrevin alpha isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS45848.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000507300.1, ENST00000684359.1
    Conserved Domains (4) summary
    COG0419
    Location:368 → 497
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:411 → 601
    MS_channel; Mechanosensitive ion channel

  19. NM_001386762.1 → NP_001373691.1  dystrobrevin alpha isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    UniProtKB/TrEMBL
    A0A7P0T8Y5
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:410 → 600
    MS_channel; Mechanosensitive ion channel

  20. NM_001386763.1 → NP_001373692.1  dystrobrevin alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000283365.10, ENST00000283365.14
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  21. NM_001386764.1 → NP_001373693.1  dystrobrevin alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  22. NM_001386765.1 → NP_001373694.1  dystrobrevin alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC013290, AC022601, AC068506
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000507911.1, ENST00000683705.1
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  23. NM_001386766.1 → NP_001373695.1  dystrobrevin alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  24. NM_001386767.1 → NP_001373696.1  dystrobrevin alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS59311.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000506495.1, ENST00000681241.1
    Conserved Domains (4) summary
    COG0419
    Location:365 → 494
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:408 → 598
    MS_channel; Mechanosensitive ion channel

  25. NM_001386768.1 → NP_001373697.1  dystrobrevin alpha isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS92450.1
    UniProtKB/TrEMBL
    A0A7P0T8Y5, A0A7P0T9L1
    Related
    ENSP00000505722.1, ENST00000681470.1
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:407 → 597
    MS_channel; Mechanosensitive ion channel

  26. NM_001386769.1 → NP_001373698.1  dystrobrevin alpha isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS92450.1
    UniProtKB/TrEMBL
    A0A7P0T8Y5, A0A7P0T9L1
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:407 → 597
    MS_channel; Mechanosensitive ion channel

  27. NM_001386770.1 → NP_001373699.1  dystrobrevin alpha isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC013290, AC022601, AC068506
    Conserved Domains (3) summary
    COG0419
    Location:395 → 530
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  28. NM_001386771.1 → NP_001373700.1  dystrobrevin alpha isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS59310.1
    UniProtKB/TrEMBL
    A0A7P0T8J4
    Related
    ENSP00000508159.1, ENST00000682483.1
    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  29. NM_001386772.1 → NP_001373701.1  dystrobrevin alpha isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC013290, AC022601, AC068506
    Consensus CDS
    CCDS59310.1
    UniProtKB/TrEMBL
    A0A7P0T8J4
    Conserved Domains (3) summary
    COG0419
    Location:365 → 500
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  30. NM_001386773.1 → NP_001373702.1  dystrobrevin alpha isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    UniProtKB/TrEMBL
    A0A7P0T8J4
    Conserved Domains (3) summary
    PRK12704
    Location:406 → 499
    PRK12704; phosphodiesterase; Provisional
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  31. NM_001386774.1 → NP_001373703.1  dystrobrevin alpha isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    UniProtKB/TrEMBL
    A0A7P0T8J4
    Conserved Domains (3) summary
    PRK12704
    Location:406 → 499
    PRK12704; phosphodiesterase; Provisional
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  32. NM_001386775.1 → NP_001373704.1  dystrobrevin alpha isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS42426.1
    UniProtKB/TrEMBL
    A0A7P0TAN3
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  33. NM_001386776.1 → NP_001373705.1  dystrobrevin alpha isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506, AC103768
    Consensus CDS
    CCDS56060.1
    UniProtKB/TrEMBL
    A0A7P0TAN3
    Related
    ENSP00000506928.1, ENST00000684734.1
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  34. NM_001386777.1 → NP_001373706.1  dystrobrevin alpha isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS56060.1
    UniProtKB/TrEMBL
    A0A7P0TAN3
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  35. NM_001386788.1 → NP_001373717.1  dystrobrevin alpha isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS92448.1
    UniProtKB/TrEMBL
    A0A7P0TBH9, A0A804HHT6
    Related
    ENSP00000506659.1, ENST00000679796.1
    Conserved Domains (4) summary
    COG0419
    Location:452 → 581
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:495 → 685
    MS_channel; Mechanosensitive ion channel

  36. NM_001386795.1 → NP_001373724.1  dystrobrevin alpha isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC022601, AC068506
    Consensus CDS
    CCDS92448.1
    UniProtKB/TrEMBL
    A0A7P0TBH9, A0A804HHT6
    Related
    ENSP00000405819.2, ENST00000444659.6
    Conserved Domains (4) summary
    COG0419
    Location:452 → 581
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:495 → 685
    MS_channel; Mechanosensitive ion channel

  37. NM_001390.5 → NP_001381.2  dystrobrevin alpha isoform 1

    See identical proteins and their annotated locations for NP_001381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as DTN1, encodes the longest isoform (1). Its 5' UTR has not been determined.
    Source sequence(s)
    AB209102, AL833285, BC005300, BC033969, BX103860, U26742, U46745
    UniProtKB/Swiss-Prot
    A8K541, A8MSZ0, A8MUY4, B4DGS6, B4DIR0, B4DIU8, M0QYX6, M0R397, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500, Q59GK7, Q9BS59, Q9Y4J8
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000382064.3, ENST00000399113.7
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam13874
    Location:470 → 553
    Nup54; Nucleoporin complex subunit 54

  38. NM_001391.5 → NP_001382.2  dystrobrevin alpha isoform 3

    See identical proteins and their annotated locations for NP_001382.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as DTN2, lacks multiple exons from the 3' end and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, BC005300, R45531, U26742, U26743, U46745
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (4) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 140
    EF-hand_2; EF hand
    pfam09069
    Location:144 → 232
    EF-hand_3; EF-hand
    pfam11068
    Location:474 → 561
    YlqD; YlqD protein

  39. NM_001392.5 → NP_001383.2  dystrobrevin alpha isoform 7

    See identical proteins and their annotated locations for NP_001383.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as DTN3 or delta transcript, lacks multiple exons from the 3' end and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (7) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC005300, DA073612, U26742
    Consensus CDS
    CCDS42426.1
    UniProtKB/TrEMBL
    A0A7P0TAN3
    Related
    ENSP00000322519.5, ENST00000315456.10
    Conserved Domains (2) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

  40. NM_032975.4 → NP_116757.2  dystrobrevin alpha isoform 2

    See identical proteins and their annotated locations for NP_116757.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as alpha transcript, lacks two consecutive in-frame coding exons, compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209102, AL833285, BC033969, BX103860, DA073612, U26742
    Consensus CDS
    CCDS45848.1
    UniProtKB/TrEMBL
    A0A804HHT6
    Related
    ENSP00000507995.1, ENST00000683379.1
    Conserved Domains (4) summary
    COG0419
    Location:368 → 497
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl39057
    Location:411 → 601
    MS_channel; Mechanosensitive ion channel

  41. NM_032978.7 → NP_116760.2  dystrobrevin alpha isoform 4

    See identical proteins and their annotated locations for NP_116760.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta transcript, lacks an internal coding exon and multiple exons from the 3' end, and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (4) with a distinct C-terminus and missing an internal segment, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, AK291156, R45531, U26744, U46745
    Consensus CDS
    CCDS11908.1
    Related
    ENSP00000336682.4, ENST00000348997.9
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl25732
    Location:422 → 557
    SMC_N; RecF/RecN/SMC N terminal domain

  42. NM_032979.5 → NP_116761.2  dystrobrevin alpha isoform 5

    See identical proteins and their annotated locations for NP_116761.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as gamma transcript, lacks two consecutive in-frame coding exons and multiple exons from the 3' end, and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (5) with a distinct C-terminus and missing an internal segment, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, DA073612, R45531, U26742, U26743
    Consensus CDS
    CCDS59309.1
    UniProtKB/TrEMBL
    A0A804HKZ4
    Related
    ENSP00000472031.1, ENST00000598774.6
    Conserved Domains (3) summary
    cd02334
    Location:241 → 289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16249
    Location:54 → 214
    EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
    cl25732
    Location:368 → 503
    SMC_N; RecF/RecN/SMC N terminal domain

  43. NM_032980.4 → NP_116762.2  dystrobrevin alpha isoform 6

    See identical proteins and their annotated locations for NP_116762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as epsilon transcript, lacks two in-frame coding exons and multiple exons from the 5' end, and contains an alternate 5' exon, compared to transcript variant 1. This results in an isoform (6) with a much shorter N-terminus and missing two internal segments, compared to isoform 1.
    Source sequence(s)
    AB209102, AL833285, BC033969, BX103860, DC327958, U46746
    Consensus CDS
    CCDS11909.1
    UniProtKB/TrEMBL
    M0QZ28
    Related
    ENSP00000467720.1, ENST00000591182.5
    Conserved Domains (1) summary
    pfam13874
    Location:118 → 201
    Nup54; Nucleoporin complex subunit 54

  44. NM_032981.5 → NP_116763.1  dystrobrevin alpha isoform 8

    See identical proteins and their annotated locations for NP_116763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as zeta transcript, lacks multiple exons from the 5' and 3' ends as well as few internal exons, and contains alternate 5' and 3' exons, compared to transcript variant 1. This results in a shorter isoform (8) with distinct N- and C-termini and lacking two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, DC327958, R45531, U26743
    Consensus CDS
    CCDS59314.1
    UniProtKB/TrEMBL
    A0A804HII3
    Related
    ENSP00000471783.1, ENST00000597674.5
    Conserved Domains (1) summary
    cl28419
    Location:98 → 168
    SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    34493312..34891844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437323.1 → XP_047293279.1  dystrobrevin alpha isoform X8

  2. XM_047437332.1 → XP_047293288.1  dystrobrevin alpha isoform X15

  3. XM_047437326.1 → XP_047293282.1  dystrobrevin alpha isoform X11

  4. XM_047437322.1 → XP_047293278.1  dystrobrevin alpha isoform X7

    UniProtKB/Swiss-Prot
    A8K541, A8MSZ0, A8MUY4, B4DGS6, B4DIR0, B4DIU8, M0QYX6, M0R397, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500, Q59GK7, Q9BS59, Q9Y4J8

  5. XM_047437318.1 → XP_047293274.1  dystrobrevin alpha isoform X3

  6. XM_047437319.1 → XP_047293275.1  dystrobrevin alpha isoform X4

  7. XM_047437328.1 → XP_047293284.1  dystrobrevin alpha isoform X13

  8. XM_047437321.1 → XP_047293277.1  dystrobrevin alpha isoform X6

  9. XM_047437316.1 → XP_047293272.1  dystrobrevin alpha isoform X1

  10. XM_047437340.1 → XP_047293296.1  dystrobrevin alpha isoform X21

  11. XM_047437317.1 → XP_047293273.1  dystrobrevin alpha isoform X2

  12. XM_047437324.1 → XP_047293280.1  dystrobrevin alpha isoform X9

  13. XM_047437336.1 → XP_047293292.1  dystrobrevin alpha isoform X18

  14. XM_047437339.1 → XP_047293295.1  dystrobrevin alpha isoform X20

    Related
    ENSP00000507082.1, ENST00000684560.1

  15. XM_047437327.1 → XP_047293283.1  dystrobrevin alpha isoform X12

    UniProtKB/TrEMBL
    A0A7P0Z4D7

  16. XM_047437330.1 → XP_047293286.1  dystrobrevin alpha isoform X15

  17. XM_047437331.1 → XP_047293287.1  dystrobrevin alpha isoform X15

  18. XM_047437320.1 → XP_047293276.1  dystrobrevin alpha isoform X5

  19. XM_047437333.1 → XP_047293289.1  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A7P0T9L1

  20. XM_047437337.1 → XP_047293293.1  dystrobrevin alpha isoform X19

  21. XM_047437338.1 → XP_047293294.1  dystrobrevin alpha isoform X20

    Related
    ENSP00000508348.1, ENST00000684610.1

  22. XM_017025575.3 → XP_016881064.1  dystrobrevin alpha isoform X5

    UniProtKB/TrEMBL
    A0A804HHT6

  23. XM_047437329.1 → XP_047293285.1  dystrobrevin alpha isoform X14

  24. XM_047437334.1 → XP_047293290.1  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A7P0T9L1

  25. XM_047437325.1 → XP_047293281.1  dystrobrevin alpha isoform X10

  26. XM_047437335.1 → XP_047293291.1  dystrobrevin alpha isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    34685119..35083714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318247.1 → XP_054174222.1  dystrobrevin alpha isoform X8

  2. XM_054318256.1 → XP_054174231.1  dystrobrevin alpha isoform X15

  3. XM_054318250.1 → XP_054174225.1  dystrobrevin alpha isoform X11

  4. XM_054318246.1 → XP_054174221.1  dystrobrevin alpha isoform X7

    UniProtKB/Swiss-Prot
    A8K541, A8MSZ0, A8MUY4, B4DGS6, B4DIR0, B4DIU8, M0QYX6, M0R397, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500, Q59GK7, Q9BS59, Q9Y4J8

  5. XM_054318241.1 → XP_054174216.1  dystrobrevin alpha isoform X3

  6. XM_054318242.1 → XP_054174217.1  dystrobrevin alpha isoform X4

  7. XM_054318252.1 → XP_054174227.1  dystrobrevin alpha isoform X13

  8. XM_054318245.1 → XP_054174220.1  dystrobrevin alpha isoform X6

  9. XM_054318239.1 → XP_054174214.1  dystrobrevin alpha isoform X1

  10. XM_054318264.1 → XP_054174239.1  dystrobrevin alpha isoform X21

  11. XM_054318240.1 → XP_054174215.1  dystrobrevin alpha isoform X2

  12. XM_054318248.1 → XP_054174223.1  dystrobrevin alpha isoform X9

  13. XM_054318260.1 → XP_054174235.1  dystrobrevin alpha isoform X18

  14. XM_054318263.1 → XP_054174238.1  dystrobrevin alpha isoform X20

  15. XM_054318254.1 → XP_054174229.1  dystrobrevin alpha isoform X15

  16. XM_054318251.1 → XP_054174226.1  dystrobrevin alpha isoform X12

    UniProtKB/TrEMBL
    A0A7P0Z4D7

  17. XM_054318255.1 → XP_054174230.1  dystrobrevin alpha isoform X15

  18. XM_054318243.1 → XP_054174218.1  dystrobrevin alpha isoform X5

  19. XM_054318257.1 → XP_054174232.1  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A7P0T9L1

  20. XM_054318261.1 → XP_054174236.1  dystrobrevin alpha isoform X19

  21. XM_054318262.1 → XP_054174237.1  dystrobrevin alpha isoform X20

  22. XM_054318244.1 → XP_054174219.1  dystrobrevin alpha isoform X5

  23. XM_054318253.1 → XP_054174228.1  dystrobrevin alpha isoform X14

  24. XM_054318258.1 → XP_054174233.1  dystrobrevin alpha isoform X16

    UniProtKB/TrEMBL
    A0A7P0T9L1

  25. XM_054318249.1 → XP_054174224.1  dystrobrevin alpha isoform X10

  26. XM_054318259.1 → XP_054174234.1  dystrobrevin alpha isoform X17

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4J8.2 GenPept UniProtKB/Swiss-Prot:Q9Y4J8

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