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ZNF92 zinc finger protein 92 [ Homo sapiens (human) ]

Gene ID: 168374, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF92provided by HGNC
Official Full Name
zinc finger protein 92provided by HGNC
Primary source
HGNC:HGNC:13168
See related
Ensembl:ENSG00000146757 MIM:603974; AllianceGenome:HGNC:13168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TF12; HPF12; HTF12; HEL-203
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 2.6), bone marrow (RPKM 2.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
7q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (65373855..65401136)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66584340..66611618)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64838768..64866049)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375334 Neighboring gene ribosomal L24 domain containing 1 pseudogene 3 Neighboring gene zinc finger protein 737 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:64838633-64838903 Neighboring gene MPRA-validated peak6540 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr7:64905072-64905245 Neighboring gene uncharacterized LOC124901660 Neighboring gene integrator complex subunit 4 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64974100-64975098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64997202-64997702 Neighboring gene uncharacterized LOC124901800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 2023909, Free PMC Article
  2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
  3. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 92
Names
epididymis luminal protein 203
zinc finger protein HTF12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287532.2 → NP_001274461.1  zinc finger protein 92 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AC092685, BC040594, BP284170, BX647875, DA939471, DB342562, T52873
    Consensus CDS
    CCDS75608.1
    UniProtKB/Swiss-Prot
    Q03936
    Related
    ENSP00000350113.2, ENST00000357512.3
    Conserved Domains (3) summary
    COG5048
    Location:195 → 547
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 43
    KRAB; KRAB box

  2. NM_001287533.2 → NP_001274462.1  zinc finger protein 92 isoform 4

    See identical proteins and their annotated locations for NP_001274462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 4 and 5 encode the same isoform (4), which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC092685, BC040594, BP284170, BX647875, DB342562, T52873
    Consensus CDS
    CCDS75609.1
    UniProtKB/TrEMBL
    C9IZS8
    Conserved Domains (3) summary
    COG5048
    Location:151 → 503
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:127 → 147
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308 → 332
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001287534.2 → NP_001274463.1  zinc finger protein 92 isoform 4

    See identical proteins and their annotated locations for NP_001274463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 4 and 5 encode the same isoform (4), which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC092685, BC040594, BX647875, DA637374, DB342562, T52873
    Consensus CDS
    CCDS75609.1
    UniProtKB/TrEMBL
    C9IZS8
    Related
    ENSP00000400495.1, ENST00000431504.1
    Conserved Domains (3) summary
    COG5048
    Location:151 → 503
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:127 → 147
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308 → 332
    zf-H2C2_2; Zinc-finger double domain

  4. NM_007139.4 → NP_009070.2  zinc finger protein 92 isoform 1

    See identical proteins and their annotated locations for NP_009070.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 1, which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC092685, BC040594, BP284170, BX647875, DA397874, DB342562, T52873
    Consensus CDS
    CCDS47596.1
    UniProtKB/Swiss-Prot
    Q03936
    Related
    ENSP00000396126.2, ENST00000450302.2
    Conserved Domains (3) summary
    COG5048
    Location:158 → 510
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:134 → 154
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:315 → 339
    zf-H2C2_2; Zinc-finger double domain

  5. NM_152626.4 → NP_689839.1  zinc finger protein 92 isoform 2

    See identical proteins and their annotated locations for NP_689839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC092685, BC040594, BP284170, BX647875, DB342562, T52873
    Consensus CDS
    CCDS34646.1
    UniProtKB/Swiss-Prot
    A6NNF9, Q03936, Q8N492, Q8NB35
    UniProtKB/TrEMBL
    V9HVY7
    Related
    ENSP00000332595.8, ENST00000328747.12
    Conserved Domains (5) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:227 → 579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:203 → 223
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:384 → 408
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    65373855..65401136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    66584340..66611618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03936.2 GenPept UniProtKB/Swiss-Prot:Q03936

Gene LinkOut

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