U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF366 zinc finger protein 366 [ Homo sapiens (human) ]

Gene ID: 167465, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF366provided by HGNC
Official Full Name
zinc finger protein 366provided by HGNC
Primary source
HGNC:HGNC:18316
See related
Ensembl:ENSG00000178175 MIM:610159; AllianceGenome:HGNC:18316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCSCRIPT; DC-SCRIPT
Summary
Enables estrogen receptor binding activity and transcription corepressor activity. Involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 4.6), fat (RPKM 4.5) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF366 in Genome Data Viewer
Location:
5q13.2; 5q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (72439903..72507410, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (72921070..72988558, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71735730..71803237, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16080 Neighboring gene ribosomal protein L10a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16081 Neighboring gene Y-box binding protein 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22651 Neighboring gene Sharpr-MPRA regulatory region 3669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16082 Neighboring gene uncharacterized LOC102503427 Neighboring gene TNPO1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:71930309-71930809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72004631-72005132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72005133-72005632 Neighboring gene ribosomal protein L7 pseudogene 22

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells. Ansems M, et al. Prostate, 2012 Dec 1. PMID 22473304
  2. Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study. Sieuwerts AM, et al. Breast Cancer Res, 2010. PMID 21122099, Free PMC Article
  3. Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation. Ansems M, et al. Biochim Biophys Acta, 2010 Dec. PMID 20478364
  4. Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators. Triantis V, et al. J Immunol, 2006 Jan 15. PMID 16393996
  5. DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation. Søndergaard JN, et al. J Immunol, 2015 Aug 15. PMID 26170389

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs.
    Title: DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.
  2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells.
    Title: DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.
  3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ.
    Title: DC-SCRIPT regulates glucocorticoid receptor function and expression of its target GILZ in dendritic cells.
  4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer.
    Title: DC-SCRIPT: AR and VDR regulator lost upon transformation of prostate epithelial cells.
  5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes.
    Title: Dendritic cell-specific transcript: dendritic cell marker and regulator of TLR-induced cytokine production.
  6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors
    Title: Clinical significance of the nuclear receptor co-regulator DC-SCRIPT in breast cancer: an independent retrospective validation study.
  7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review]
    Title: Crosstalk and DC-SCRIPT: expanding nuclear receptor modulation.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study
    Title: Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
  10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association with bone mass and geometry in the Framingham Heart Study.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: MRPS27

Homology

Clone Names

  • FLJ33375, FLJ39796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to estrogen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 366
Names
dendritic cell-specific transcript protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152625.3 → NP_689838.1  zinc finger protein 366

    See identical proteins and their annotated locations for NP_689838.1

    Status: VALIDATED

    Source sequence(s)
    AC093278, AK097115, BK000210
    Consensus CDS
    CCDS4015.1
    UniProtKB/Swiss-Prot
    Q5HYI9, Q7RTV4, Q8N895
    UniProtKB/TrEMBL
    Q0VAH5
    Related
    ENSP00000313158.5, ENST00000318442.6
    Conserved Domains (2) summary
    COG5048
    Location:253 → 549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    72439903..72507410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    72921070..72988558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N895.1 GenPept UniProtKB/Swiss-Prot:Q8N895

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous