OXER1 oxoeicosanoid receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OXER1provided by HGNC
Official Full Name: oxoeicosanoid receptor 1provided by HGNC
Primary source: HGNC:HGNC:24884
See related: Ensembl:ENSG00000162881 MIM:620064; AllianceGenome:HGNC:24884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPCR; GPR170; TG1019
Summary: Enables G protein-coupled receptor activity and icosanoid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 2p21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (42762499..42764135, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (42767768..42769404, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (42989639..42991275, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OXER1 mediates testosterone-induced calcium responses in prostate cancer cells.
Title: OXER1 mediates testosterone-induced calcium responses in prostate cancer cells.
Enhanced OXER1 expression is indispensable for human cancer cell migration.
Title: Enhanced OXER1 expression is indispensable for human cancer cell migration.
The G protein coupled oxo-eicosanoid receptor 1 (OXER1) (a receptor of the arachidonic acid metabolite, 5-oxoeicosatetraenoic acid, 5-oxoETE) is as a novel mAR involved in the rapid effects of androgens.
Title: Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.
These findings verify that membrane-acting androgens exert specific effects through an antagonistic interaction with OXER1. Additionally, this interaction between androgen and OXER1, which is an arachidonic acid metabolite receptor expressed in prostate cancer, provides a novel link between steroid and lipid actions and renders OXER1 as new player in the disease.
Title: Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer.
membrane receptor OxeR1 is involved in StAR protein induction and activation of steroidogenesis triggered by cAMP or angiotensin II, acting, at least in part, through ERK1/2 activation.
Title: OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.
Gue1654 as a non-Galphai-biased antagonist of OXE-R that provides a new basis for therapeutic intervention in inflammatory diseases that involve activation of eosinophils, neutrophils, and monocytes.
Title: A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.
OXER1 has a role in regulating the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells
Title: OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Identification of a novel human receptor coupled to G(i/o).
Title: Identification of a novel human eicosanoid receptor coupled to G(i/o).
identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages
Title: Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
5-oxoER is critical for prostate cancer cell survival.
Title: Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80146 (e-PCR)
- UniSTS:84822

RH80145 (e-PCR)
- UniSTS:84823

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: oxoeicosanoid receptor 1

Names: 5-oxo-ETE G-protein coupled receptor; 5-oxo-ETE acid G-protein-coupled receptor 1; G-protein coupled receptor 170; G-protein coupled receptor R527; G-protein coupled receptor TG1019; OXE receptor; oxoeicosanoid (OXE) receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_148962.5 → NP_683765.2 oxoeicosanoid receptor 1

Status: VALIDATED

Source sequence(s)

AC098824

Consensus CDS

CCDS1810.2

UniProtKB/Swiss-Prot

Q86WP7, Q8NGW4, Q8TDS5

Related

ENSP00000367930.3, ENST00000378661.4

Conserved Domains (1) summary

cd15200
Location:54 → 327

7tmA_OXER1; oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors