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ZNF846 zinc finger protein 846 [ Homo sapiens (human) ]

Gene ID: 162993, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF846provided by HGNC
Official Full Name
zinc finger protein 846provided by HGNC
Primary source
HGNC:HGNC:27260
See related
Ensembl:ENSG00000196605 AllianceGenome:HGNC:27260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF846 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9748619..9786160, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9874759..9912301, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9859295..9896836, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372270 Neighboring gene zinc finger protein 562 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9879342-9880207 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:9889978-9890153 Neighboring gene ubiquitin conjugating enzyme E2 L4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9894821-9895652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9895653-9896484 Neighboring gene uncharacterized LOC100505555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10041 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9903248-9903748 Neighboring gene uncharacterized LOC124904635 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9903749-9904249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10044 Neighboring gene F-box and leucine rich repeat protein 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
  2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 846
Names
zinc finger protein 420 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077624.3 → NP_001071092.1  zinc finger protein 846 isoform 1

    See identical proteins and their annotated locations for NP_001071092.1

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Consensus CDS
    CCDS42496.1
    UniProtKB/Swiss-Prot
    A8K0H1, B3KUP1, Q147U1
    Related
    ENSP00000380999.1, ENST00000397902.7
    Conserved Domains (6) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:106 → 496
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368 → 388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:338 → 360
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 45
    KRAB; KRAB box
    pfam13465
    Location:464 → 489
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001353798.2 → NP_001340727.1  zinc finger protein 846 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Conserved Domains (2) summary
    COG5048
    Location:2 → 367
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239 → 259
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001353799.2 → NP_001340728.1  zinc finger protein 846 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Conserved Domains (3) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:105 → 495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001353800.3 → NP_001340729.1  zinc finger protein 846 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) initiates at an upstream alternate promoter and differs at both the 5' and 3' ends compared to variant 1. The encoded isoform (4) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5189
    Location:249 → 327
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001395830.1 → NP_001382759.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5189
    Location:250 → 328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001395831.1 → NP_001382760.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5189
    Location:250 → 328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001395832.1 → NP_001382761.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5189
    Location:250 → 328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001395833.1 → NP_001382762.1  zinc finger protein 846 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:214 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:192 → 212
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001395834.1 → NP_001382763.1  zinc finger protein 846 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:214 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:192 → 212
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001395835.1 → NP_001382764.1  zinc finger protein 846 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    COG5189
    Location:213 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 30
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  11. NM_001395836.1 → NP_001382765.1  zinc finger protein 846 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:193 → 271
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. NM_001395837.1 → NP_001382766.1  zinc finger protein 846 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:193 → 271
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. NM_001395838.1 → NP_001382767.1  zinc finger protein 846 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:151 → 229
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. NM_001395839.1 → NP_001382768.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Consensus CDS
    CCDS92508.1
    Conserved Domains (2) summary
    COG5189
    Location:121 → 199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99 → 119
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. NM_001395840.1 → NP_001382769.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Consensus CDS
    CCDS92508.1
    Conserved Domains (2) summary
    COG5189
    Location:121 → 199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99 → 119
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. NM_001395841.1 → NP_001382770.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Consensus CDS
    CCDS92508.1
    Conserved Domains (2) summary
    COG5189
    Location:121 → 199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99 → 119
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. NM_001395842.1 → NP_001382771.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Consensus CDS
    CCDS92508.1
    Related
    ENSP00000467891.1, ENST00000592859.1
    Conserved Domains (2) summary
    COG5189
    Location:121 → 199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99 → 119
    ZF_C2H2; C2H2 Zn finger [structural motif]

  18. NM_001395843.1 → NP_001382772.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Consensus CDS
    CCDS92508.1
    Conserved Domains (2) summary
    COG5189
    Location:121 → 199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99 → 119
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_172869.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

  2. NR_172870.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

  3. NR_172871.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

  4. NR_172872.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

  5. NR_172873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9748619..9786160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9874759..9912301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024149.1: Suppressed sequence

    Description
    NG_024149.1: This RefSeq was removed because it is primarily UTR sequence.

  2. NR_148544.1: Suppressed sequence

    Description
    NR_148544.1: This RefSeq was removed because currently there is no support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q147U1.2 GenPept UniProtKB/Swiss-Prot:Q147U1

Gene LinkOut

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