SLFN5 schlafen family member 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLFN5provided by HGNC
Official Full Name: schlafen family member 5provided by HGNC
Primary source: HGNC:HGNC:28286
See related: Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 17q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (35243072..35273655)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36191007..36221590)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (33570091..33600674)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
Title: SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
Title: Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
Title: SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
Title: Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
Title: Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
This is the first study to report that SLFN5 inhibits cancer migration and invasiveness in several common cancer cell lines by repressing MT1-MMP expression via the AKT/GSK-3beta/beta-catenin signalling pathway, suggesting that SLFN5 plays wide inhibitory roles in various cancers.
Title: SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.
Study results demonstrated that overexpression of SLFN5 promoted the morphology transformation of lung cancer cell line A549 from epithelial to mesenchymal, as well as migration and invasion. However, knockdown of SLFN5 resulted in the opposite results. Results suggest that SLFN5 may act as a synergist in lung cancer cell tumorigenesis and progression through beta-catenin/Snail/E-cadherin pathway.
Title: Overexpression of SLFN5 induced the epithelial-mesenchymal transition in human lung cancer cell line A549 through β-catenin/Snail/E-cadherin pathway.
Type-I IFN treatment triggers the interaction of STAT1 with SLFN5, and the resulting complex negatively controls STAT1-mediated gene transcription via interferon stimulated response elements
Title: Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
In this study population, elevated SLFN5 protein expression in patients with intestinal metaplasia correlated with progression to gastric cancer
Title: SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer.
SLFN5 exhibits key roles in controlling motility and invasiveness of renal cell carcinoma cells by negatively controlling expression of MMP-1, MMP-13, and several other genes involved in the control of malignant cell motility.
Title: Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif interacts with SLFN5	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-145866 (e-PCR)
- UniSTS:183041

RH45715 (e-PCR)
- UniSTS:56427

RH79990 (e-PCR)
- UniSTS:87030

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: schlafen family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330183.2 → NP_001317112.1 schlafen family member 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC022706, AK303632, BQ023439

Consensus CDS

CCDS82106.1

UniProtKB/TrEMBL

B4E128

Related

ENSP00000440537.1, ENST00000542451.1
NM_144975.4 → NP_659412.3 schlafen family member 5 isoform 1

See identical proteins and their annotated locations for NP_659412.3

Status: VALIDATED

Source sequence(s)

AC022706, BC125200, BP281007, BX102817

Consensus CDS

CCDS32619.1

UniProtKB/Swiss-Prot

Q08AF2, Q08AF3, Q8WU54, Q96A82

UniProtKB/TrEMBL

B4E0B1

Related

ENSP00000299977.3, ENST00000299977.9

Conserved Domains (3) summary

cl21455
Location:574 → 657

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

cl22977
Location:839 → 886

UvrD_C_2; UvrD-like helicase C-terminal domain

cl27772
Location:34 → 332

B3R; Poxviridae B3 protein