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EML5 EMAP like 5 [ Homo sapiens (human) ]

Gene ID: 161436, updated on 5-Mar-2024

Summary

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Official Symbol
EML5provided by HGNC
Official Full Name
EMAP like 5provided by HGNC
Primary source
HGNC:HGNC:18197
See related
Ensembl:ENSG00000165521 MIM:618119; AllianceGenome:HGNC:18197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP16; EMAP-2; EMAP-5
Summary
Predicted to enable microtubule binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary (RPKM 10.1), prostate (RPKM 3.2) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
14q31.3
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88612431..88792953, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82833321..83016566, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89078775..89259297, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8844 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eml5, a novel WD40 domain protein expressed in rat brain. O'Connor V, et al. Gene, 2004 Jul 7. PMID 15225882
  2. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, et al. Mol Cell Biol, 2015 Jan. PMID 25332235, Free PMC Article
  3. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Kim SO, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299191, Free PMC Article
  4. A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase. Low TY, et al. Sci Signal, 2014 Dec 16. PMID 25515538
  5. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781D1122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 5
Names
echinoderm microtubule associated protein like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385116.1 → NP_001372045.1  echinoderm microtubule-associated protein-like 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL121768, AL162171
    Conserved Domains (4) summary
    COG2319
    Location:1403 → 1811
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001385117.1 → NP_001372046.1  echinoderm microtubule-associated protein-like 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121768
    Conserved Domains (3) summary
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    cl29593
    Location:725 → 1026
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001411033.1 → NP_001397962.1  echinoderm microtubule-associated protein-like 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL121768, AL162171
    Consensus CDS
    CCDS91916.1
    UniProtKB/Swiss-Prot
    B9EK59, Q05BV3, Q5H9N6, Q6UYC9, Q6ZRP3, Q6ZT03
    Related
    ENSP00000370039.5, ENST00000380664.9

  4. NM_183387.3 → NP_899243.1  echinoderm microtubule-associated protein-like 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL121768, AL162171, BC032685, BC042055, BC150639
    Consensus CDS
    CCDS45148.1
    UniProtKB/Swiss-Prot
    Q05BV3
    Related
    ENSP00000451998.1, ENST00000554922.6
    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    88612431..88792953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431057.1 → XP_047287013.1  echinoderm microtubule-associated protein-like 5 isoform X15

  2. XM_017021065.3 → XP_016876554.1  echinoderm microtubule-associated protein-like 5 isoform X8

  3. XM_047431056.1 → XP_047287012.1  echinoderm microtubule-associated protein-like 5 isoform X9

  4. XM_017021066.3 → XP_016876555.1  echinoderm microtubule-associated protein-like 5 isoform X11

  5. XM_011536533.4 → XP_011534835.1  echinoderm microtubule-associated protein-like 5 isoform X10

    Conserved Domains (4) summary
    COG2319
    Location:353 → 891
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:775 → 814
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1025
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_017021064.3 → XP_016876553.1  echinoderm microtubule-associated protein-like 5 isoform X7

  7. XM_011536531.4 → XP_011534833.1  echinoderm microtubule-associated protein-like 5 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_011536530.4 → XP_011534832.1  echinoderm microtubule-associated protein-like 5 isoform X2

    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_017021063.3 → XP_016876552.1  echinoderm microtubule-associated protein-like 5 isoform X4

  10. XM_017021068.3 → XP_016876557.1  echinoderm microtubule-associated protein-like 5 isoform X13

  11. XM_011536532.4 → XP_011534834.1  echinoderm microtubule-associated protein-like 5 isoform X6

    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  12. XM_017021062.3 → XP_016876551.1  echinoderm microtubule-associated protein-like 5 isoform X3

  13. XM_011536528.4 → XP_011534830.1  echinoderm microtubule-associated protein-like 5 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_017021067.3 → XP_016876556.1  echinoderm microtubule-associated protein-like 5 isoform X12

  15. XM_011536534.4 → XP_011534836.1  echinoderm microtubule-associated protein-like 5 isoform X14

    Conserved Domains (4) summary
    COG2319
    Location:294 → 784
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:612 → 655
    HELP; HELP motif
    sd00039
    Location:7 → 45
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:666 → 1004
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  16. XM_017021069.3 → XP_016876558.1  echinoderm microtubule-associated protein-like 5 isoform X14

    Conserved Domains (4) summary
    COG2319
    Location:294 → 784
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:612 → 655
    HELP; HELP motif
    sd00039
    Location:7 → 45
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:666 → 1004
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  17. XM_047431060.1 → XP_047287016.1  echinoderm microtubule-associated protein-like 5 isoform X20

  18. XM_011536536.3 → XP_011534838.1  echinoderm microtubule-associated protein-like 5 isoform X17

    Conserved Domains (4) summary
    COG2319
    Location:353 → 843
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:64 → 104
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  19. XM_047431058.1 → XP_047287014.1  echinoderm microtubule-associated protein-like 5 isoform X16

  20. XM_017021070.2 → XP_016876559.1  echinoderm microtubule-associated protein-like 5 isoform X18

  21. XM_047431059.1 → XP_047287015.1  echinoderm microtubule-associated protein-like 5 isoform X19

  22. XM_047431061.1 → XP_047287017.1  echinoderm microtubule-associated protein-like 5 isoform X21

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    82833321..83016566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375531.1 → XP_054231506.1  echinoderm microtubule-associated protein-like 5 isoform X15

  2. XM_054375523.1 → XP_054231498.1  echinoderm microtubule-associated protein-like 5 isoform X8

  3. XM_054375524.1 → XP_054231499.1  echinoderm microtubule-associated protein-like 5 isoform X9

  4. XM_054375526.1 → XP_054231501.1  echinoderm microtubule-associated protein-like 5 isoform X11

  5. XM_054375525.1 → XP_054231500.1  echinoderm microtubule-associated protein-like 5 isoform X10

  6. XM_054375522.1 → XP_054231497.1  echinoderm microtubule-associated protein-like 5 isoform X7

  7. XM_054375520.1 → XP_054231495.1  echinoderm microtubule-associated protein-like 5 isoform X5

  8. XM_054375517.1 → XP_054231492.1  echinoderm microtubule-associated protein-like 5 isoform X2

  9. XM_054375519.1 → XP_054231494.1  echinoderm microtubule-associated protein-like 5 isoform X4

  10. XM_054375528.1 → XP_054231503.1  echinoderm microtubule-associated protein-like 5 isoform X13

  11. XM_054375521.1 → XP_054231496.1  echinoderm microtubule-associated protein-like 5 isoform X6

  12. XM_054375518.1 → XP_054231493.1  echinoderm microtubule-associated protein-like 5 isoform X3

  13. XM_054375516.1 → XP_054231491.1  echinoderm microtubule-associated protein-like 5 isoform X1

  14. XM_054375527.1 → XP_054231502.1  echinoderm microtubule-associated protein-like 5 isoform X12

  15. XM_054375530.1 → XP_054231505.1  echinoderm microtubule-associated protein-like 5 isoform X14

  16. XM_054375529.1 → XP_054231504.1  echinoderm microtubule-associated protein-like 5 isoform X14

  17. XM_054375536.1 → XP_054231511.1  echinoderm microtubule-associated protein-like 5 isoform X20

  18. XM_054375533.1 → XP_054231508.1  echinoderm microtubule-associated protein-like 5 isoform X17

  19. XM_054375532.1 → XP_054231507.1  echinoderm microtubule-associated protein-like 5 isoform X16

  20. XM_054375534.1 → XP_054231509.1  echinoderm microtubule-associated protein-like 5 isoform X18

  21. XM_054375535.1 → XP_054231510.1  echinoderm microtubule-associated protein-like 5 isoform X19

  22. XM_054375537.1 → XP_054231512.1  echinoderm microtubule-associated protein-like 5 isoform X21

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05BV3.3 GenPept UniProtKB/Swiss-Prot:Q05BV3

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