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DAPK1 death associated protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 1612, updated on 7-Apr-2024

Summary

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Official Symbol
DAPK1provided by HGNC
Official Full Name
death associated protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:2674
See related
Ensembl:ENSG00000196730 MIM:600831; AllianceGenome:HGNC:2674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAPK; ROCO3
Summary
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q21.33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87497228..87708634)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (99650695..99862240)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90112143..90323549)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376127 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90001899-90002782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017019-90017636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017637-90018252 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:90020422-90020972 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene hESC enhancers GRCh37_chr9:90024569-90025224 and GRCh37_chr9:90025225-90025878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90025879-90026532 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90031115-90031768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:90113131-90113888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90145230-90146212 Neighboring gene ribosomal protein S29 pseudogene 18 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108388 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108397 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90178705-90179204 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108408 Neighboring gene DAPK1 intronic transcript 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90186048-90186548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90207629-90208129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90215267-90215860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90234560-90235060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90249751-90250336 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90308876-90309094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:90314444-90315643 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:90317453-90318652 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:90328302-90329501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28523 Neighboring gene CTSL promoter region Neighboring gene CTSL 3' regulatory element Neighboring gene EIF3J pseudogene 3 Neighboring gene cathepsin L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Noori T, et al. Neurochem Res, 2022 Aug. PMID 35674928
  2. Neurodegenerative effect of DAPK1 after cerebral hypoxia-ischemia is associated with its post-transcriptional and signal transduction regulations: A systematic review and meta-analysis. Khan ZA, et al. Ageing Res Rev, 2022 Apr. PMID 35202858
  3. The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer. Movahhed P, et al. Mol Biol Rep, 2022 Jun. PMID 35083613
  4. Death-Associated Protein Kinase 1 Inhibits Progression of Thyroid Cancer by Regulating Stem Cell Markers. You MH, et al. Cells, 2021 Nov 3. PMID 34831219, Free PMC Article
  5. Death-Associated Protein Kinase 1 Regulates Oxidative Stress in Cardiac Ischemia Reperfusion Injury. Li W, et al. Cells Tissues Organs, 2021. PMID 34348268

See all (280) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
    Title: Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
  2. The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
    Title: The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
  3. BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
    Title: BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
  4. Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
    Title: Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
  5. Knockdown of DAPK1 inhibits IL-1beta-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-kappaB and NLRP3 inflammasome pathway.
    Title: Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway.
  6. Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
    Title: Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
  7. NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
    Title: NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
  8. MiR-191-5p Attenuates Tau Phosphorylation, Abeta Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.
    Title: MiR-191-5p Attenuates Tau Phosphorylation, Aβ Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.
  9. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke.
    Title: Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke.
  10. The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma.
    Title: The prognostic value of autophagy related genes with potential protective function in Ewing sarcoma.
Submit: New GeneRIF Correction See all GeneRIFs (233)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
EBI GWAS Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781I035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables syntaxin-1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to tumor cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of autophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of response to tumor cell IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DAPK1-calmodulin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
death-associated protein kinase 1
Names
DAP kinase 1
NP_001275658.1
NP_001275659.1
NP_001275660.1
NP_004929.2
XP_005251814.1
XP_016869849.1
XP_047278842.1
XP_047278843.1
XP_047278844.1
XP_054218179.1
XP_054218180.1
XP_054218181.1
XP_054218182.1
XP_054218183.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029883.1 RefSeqGene

    Range
    5027..215794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288729.2 → NP_001275658.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000484267.1, ENST00000622514.4
    Conserved Domains (5) summary
    PLN03192
    Location:515 → 768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367 → 639
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001288730.2 → NP_001275659.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AB208871, BC113660, BC143733, DC340223, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000417076.1, ENST00000472284.5
    Conserved Domains (5) summary
    PLN03192
    Location:515 → 768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367 → 639
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001288731.2 → NP_001275660.1  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_001275660.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL160279, AL161787, AL591852, BC113660, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000350785.5, ENST00000358077.9
    Conserved Domains (5) summary
    PLN03192
    Location:515 → 768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367 → 639
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_004938.4 → NP_004929.2  death-associated protein kinase 1

    See identical proteins and their annotated locations for NP_004929.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK295119, BC113660, BG110813, CX872304, DR002874, H77515
    Consensus CDS
    CCDS43842.1
    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
    UniProtKB/TrEMBL
    B4DHI4
    Related
    ENSP00000386135.3, ENST00000408954.8
    Conserved Domains (5) summary
    PLN03192
    Location:515 → 768
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    cl39094
    Location:367 → 639
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    87497228..87708634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422887.1 → XP_047278843.1  death-associated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

  2. XM_047422886.1 → XP_047278842.1  death-associated protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

  3. XM_005251757.5 → XP_005251814.1  death-associated protein kinase 1 isoform X3

    Conserved Domains (6) summary
    smart00220
    Location:13 → 275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:505 → 629
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    pfam12796
    Location:449 → 541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347 → 399
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]

  4. XM_047422888.1 → XP_047278844.1  death-associated protein kinase 1 isoform X4

  5. XM_017014360.2 → XP_016869849.1  death-associated protein kinase 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    99650695..99862240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362205.1 → XP_054218180.1  death-associated protein kinase 1 isoform X1

  2. XM_054362204.1 → XP_054218179.1  death-associated protein kinase 1 isoform X1

  3. XM_054362207.1 → XP_054218182.1  death-associated protein kinase 1 isoform X3

  4. XM_054362208.1 → XP_054218183.1  death-associated protein kinase 1 isoform X4

  5. XM_054362206.1 → XP_054218181.1  death-associated protein kinase 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53355.6 GenPept UniProtKB/Swiss-Prot:P53355

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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