U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AMOT angiomotin [ Homo sapiens (human) ]

Gene ID: 154796, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
AMOTprovided by HGNC
Official Full Name
angiomotinprovided by HGNC
Primary source
HGNC:HGNC:17810
See related
Ensembl:ENSG00000126016 MIM:300410; AllianceGenome:HGNC:17810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
Xq23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (112774877..112840831, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (111226753..111292678, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (112018105..112084059, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29863 Neighboring gene LHFPL tetraspan subfamily member 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:111911869-111912514 Neighboring gene high mobility group box 3 pseudogene 30 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:111981774-111982356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:112022621-112023121 Neighboring gene microRNA 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20945 Neighboring gene uncharacterized LOC107985651 Neighboring gene NANOG hESC enhancer GRCh37_chrX:112094284-112095066 Neighboring gene RNA, 7SL, cytoplasmic 266, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Emerging roles for angiomotin in the nervous system. Wigerius M, et al. Sci Signal, 2020 Oct 27. PMID 33109746
  2. Angiomotin regulates budding and spread of Ebola virus. Han Z, et al. J Biol Chem, 2020 Jun 19. PMID 32381509, Free PMC Article
  3. AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells. Brunner P, et al. Mol Biol Cell, 2020 Jan 15. PMID 31800378, Free PMC Article
  4. Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia. Farrell A, et al. JCI Insight, 2019 Apr 18. PMID 30996134, Free PMC Article
  5. Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer. Yang J, et al. Cell Death Dis, 2019 Feb 21. PMID 30792381, Free PMC Article

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
    Title: Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
  2. Emerging roles for angiomotin in the nervous system.
    Title: Emerging roles for angiomotin in the nervous system.
  3. CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression.
    Title: CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression.
  4. Angiomotin regulates budding and spread of Ebola virus.
    Title: Angiomotin regulates budding and spread of Ebola virus.
  5. AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells.
    Title: AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells.
  6. AMOT is primarily expressed in migratory extravillous trophoblast cells (EVTs) and its expression increases after 10 weeks of gestation when oxygen tension rises and EVT migration/invasion peaks. In preeclampsia, however, AMOT expression is decreased and its localization to migratory fetomaternal interface EVTs is disrupted. JMJD6 an oxygen sensor, positively regulates AMOT via oxygen-dependent lysyl hydroxylation.
    Title: Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia.
  7. Findings that angiomotin (AMOT)-dependent regulation of Yes-associated protein (YAP) directing human pluripotent stem cells (hPSCs) fate suggest the molecular mechanisms by which the microenvironment can induce neural differentiation.
    Title: Angiomotin Regulates YAP Localization during Neural Differentiation of Human Pluripotent Stem Cells.
  8. Amot-p130 functions as a tumor suppressor gene in breast cancer, disrupting beta-catenin stability by competing with Axin for binding to tankyrase.
    Title: Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.
  9. We have been suggested that AmotP130 suppressed the invasion ability through remodelling of the cytoskeleton of breast cancer cells, involving regulation of the Rho pathway. The cytoskeleton-related pathway components may provide novel, clinically therapeutic targets for breast cancer treatment.
    Title: AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.
  10. AMOT, AMOTL1, and AMOTL2 enhance Hippo signaling by stimulating LATS1/2 autophosphorylation and by connecting LATS1/2 with both its activator SAV1-MST1/2 and its substrate YAP.
    Title: Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of angiomotin (AMOT) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Angiomotin (AMOT) depletion inhibits HIV-1 Gag release from cells, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
gag Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner from 293T, HeLa, and Jurkat cells PubMed
gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables angiostatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
angiomotin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012628.1 RefSeqGene

    Range
    4985..70939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113490.2 → NP_001106962.1  angiomotin isoform 1

    See identical proteins and their annotated locations for NP_001106962.1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS48154.1
    UniProtKB/Swiss-Prot
    Q4VCS5, Q504X5, Q9HD27, Q9UPT1
    Related
    ENSP00000361027.3, ENST00000371959.9
    Conserved Domains (3) summary
    COG1196
    Location:431 → 676
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK10263
    Location:191 → 328
    PRK10263; DNA translocase FtsK; Provisional
    pfam12240
    Location:599 → 806
    Angiomotin_C; Angiomotin C terminal

  2. NM_001386998.1 → NP_001373927.1  angiomotin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS48154.1
    UniProtKB/Swiss-Prot
    Q4VCS5, Q504X5, Q9HD27, Q9UPT1
    Conserved Domains (3) summary
    COG1196
    Location:431 → 676
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK10263
    Location:191 → 328
    PRK10263; DNA translocase FtsK; Provisional
    pfam12240
    Location:599 → 806
    Angiomotin_C; Angiomotin C terminal

  3. NM_001386999.1 → NP_001373928.1  angiomotin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS48154.1
    UniProtKB/Swiss-Prot
    Q4VCS5, Q504X5, Q9HD27, Q9UPT1
    Conserved Domains (3) summary
    COG1196
    Location:431 → 676
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK10263
    Location:191 → 328
    PRK10263; DNA translocase FtsK; Provisional
    pfam12240
    Location:599 → 806
    Angiomotin_C; Angiomotin C terminal

  4. NM_133265.5 → NP_573572.1  angiomotin isoform 2

    See identical proteins and their annotated locations for NP_573572.1

    Status: REVIEWED

    Source sequence(s)
    AC004827
    Consensus CDS
    CCDS14563.1
    UniProtKB/TrEMBL
    A2BDD9
    Related
    ENSP00000305557.1, ENST00000304758.5
    Conserved Domains (1) summary
    pfam12240
    Location:190 → 393
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    112774877..112840831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441856.1 → XP_047297812.1  angiomotin isoform X1

    UniProtKB/Swiss-Prot
    Q4VCS5, Q504X5, Q9HD27, Q9UPT1

  2. XM_047441857.1 → XP_047297813.1  angiomotin isoform X1

    UniProtKB/Swiss-Prot
    Q4VCS5, Q504X5, Q9HD27, Q9UPT1

  3. XM_005262090.1 → XP_005262147.1  angiomotin isoform X2

    See identical proteins and their annotated locations for XP_005262147.1

    UniProtKB/TrEMBL
    A2BDD9
    Conserved Domains (1) summary
    pfam12240
    Location:190 → 393
    Angiomotin_C; Angiomotin C terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    111226753..111292678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VCS5.1 GenPept UniProtKB/Swiss-Prot:Q4VCS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous