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SLC2A12 solute carrier family 2 member 12 [ Homo sapiens (human) ]

Gene ID: 154091, updated on 5-Mar-2024

Summary

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Official Symbol
SLC2A12provided by HGNC
Official Full Name
solute carrier family 2 member 12provided by HGNC
Primary source
HGNC:HGNC:18067
See related
Ensembl:ENSG00000146411 MIM:610372; AllianceGenome:HGNC:18067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUT12
Summary
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in prostate (RPKM 9.5), endometrium (RPKM 4.6) and 18 other tissues See more
Orthologs
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Genomic context

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See SLC2A12 in Genome Data Viewer
Location:
6q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (133987581..134052624, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (135175590..135240550, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134308719..134373762, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:134209799-134210712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134211964-134212728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:134213614-134214222 Neighboring gene transcription factor 21 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17555 Neighboring gene umcharacterized LOC128092253 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90026 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25081 Neighboring gene TATA-box binding protein like 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90037 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:134381498-134382162 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:134382163-134382827 Neighboring gene uncharacterized LOC124901404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17556 Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alternative Splicing and Cleavage of GLUT8. Alexander CM, et al. Mol Cell Biol, 2020 Dec 21. PMID 33077497, Free PMC Article
  2. Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions. Matsui C, et al. Anticancer Res, 2017 Dec. PMID 29187448
  3. Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods. Pujol-Giménez J, et al. Am J Physiol Cell Physiol, 2015 Jun 15. PMID 25855082
  4. Expression of the glucose transporter GLUT12 in Alzheimer's disease patients. Pujol-Gimenez J, et al. J Alzheimers Dis, 2014. PMID 24820014
  5. Glucose transporter GLUT12-functional characterization in Xenopus laevis oocytes. Rogers S, et al. Biochem Biophys Res Commun, 2003 Aug 29. PMID 12914765

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
    Title: Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.
  2. Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
    Title: Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.
  3. Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
    Title: Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.
  4. Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
    Title: Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.
  5. Alternative Splicing and Cleavage of GLUT8.
    Title: Alternative Splicing and Cleavage of GLUT8.
  6. We hypothesize that GLUT12 would contribute to modulate sugar absorption in physiological and pathophysiological situations such as obesity.
    Title: GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.
  7. GLUT12 rapid translocation to the enterocytes apical membrane in response to glucose and insulin could be related to GLUT12 participation in sugar absorption during postprandial periods. In the pathological condition of obesity, in which insulin sensitivity is reduced, the contribution of GLUT12 to sugar absorption would be affected.
    Title: GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.
  8. GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations.
    Title: Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions.
  9. GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties.
    Title: Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
  10. findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls
    Title: Expression of the glucose transporter GLUT12 in Alzheimer's disease patients.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 12
Names
GLUT-12
glucose transporter type 12
solute carrier family 2 (facilitated glucose transporter), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145176.3 → NP_660159.1  solute carrier family 2, facilitated glucose transporter member 12

    See identical proteins and their annotated locations for NP_660159.1

    Status: VALIDATED

    Source sequence(s)
    AL035699, AL833602, AY046419, DB253903
    Consensus CDS
    CCDS5169.1
    UniProtKB/Swiss-Prot
    B3KV17, Q7Z6U3, Q8TD20, Q96MR8
    Related
    ENSP00000275230.5, ENST00000275230.6
    Conserved Domains (1) summary
    pfam00083
    Location:44 → 561
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    133987581..134052624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010311.3 → XP_016865800.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

  2. XM_006715349.5 → XP_006715412.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:45 → 363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:43 → 371
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    135175590..135240550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354352.1 → XP_054210327.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X2

  2. XM_054354351.1 → XP_054210326.1  solute carrier family 2, facilitated glucose transporter member 12 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TD20.1 GenPept UniProtKB/Swiss-Prot:Q8TD20

Gene LinkOut

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