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CSK C-terminal Src kinase [ Homo sapiens (human) ]

Gene ID: 1445, updated on 11-Apr-2024

Summary

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Official Symbol
CSKprovided by HGNC
Official Full Name
C-terminal Src kinaseprovided by HGNC
Primary source
HGNC:HGNC:2444
See related
Ensembl:ENSG00000103653 MIM:124095; AllianceGenome:HGNC:2444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Expression
Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See CSK in Genome Data Viewer
Location:
15q24.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74782080..74803197)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72651992..72673091)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75074421..75095538)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CYP1A1 5' regulatory region Neighboring gene cytochrome P450 family 1 subfamily A member 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:75021499-75022227 Neighboring gene CYP1A2 5' regulatory region Neighboring gene cytochrome P450 family 1 subfamily A member 2 Neighboring gene dioxin-responsive -38 kb CYP1A2 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75059675-75060452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75063617-75064332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75064333-75065046 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75066003-75066580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75070096-75070626 Neighboring gene Sharpr-MPRA regulatory region 4992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6657 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75075123-75075698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9796 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75080141-75080318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75084649-75085478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75085479-75086307 Neighboring gene microRNA 4513 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:75090696-75091895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75092171-75093022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75093023-75093872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75112197-75113010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75113011-75113824 Neighboring gene lectin, mannose binding 1 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75114639-75115451 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75118950-75119157 Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C-src tyrosine kinase gene rs1378942 polymorphism and hypertension in Asians: Review and meta-analysis. Qian X, et al. Clin Chim Acta, 2018 Dec. PMID 30291896
  2. Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein. Potuckova L, et al. Front Immunol, 2018. PMID 30116247, Free PMC Article
  3. Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src. Wang L, et al. Neurochem Int, 2018 Nov. PMID 30041015
  4. Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling. Liu D, et al. Protein Cell, 2017 Jan. PMID 27815825, Free PMC Article
  5. Identification and characterization of the role of c-terminal Src kinase in dengue virus replication. Kumar R, et al. Sci Rep, 2016 Jul 26. PMID 27457684, Free PMC Article

See all (282) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
    Title: SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
  2. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2alpha and platelet aggregation in diabetic and normal platelets.
    Title: Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets.
  3. Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
    Title: Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
  4. CSK promotes innate immune response to DNA virus by phosphorylating MITA.
    Title: CSK promotes innate immune response to DNA virus by phosphorylating MITA.
  5. CD28 functions as a novel adaptor protein for CSK, and CSK regulates signaling downstream of CD28
    Title: Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling.
  6. Here we report that Csk is covalently modified by SUMO1 at lysine 53 (K53) both in vitro and in vivo. Treatment with hydrogen peroxide inhibited this modification to a certain extent, but PIAS3, identified as the main specific SUMO E3 ligase for Csk, could significantly enhance SUMO1-Csk level
    Title: SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.
  7. results demonstrate that c-Src directly phosphorylates the Notch intracellular domain at specific tyrosine residues and that mutation of these phosphorylation sites increases Notch responsive transcriptional activity.
    Title: Src kinase phosphorylates Notch1 to inhibit MAML binding.
  8. This study demonstrate that in FcepsilonRI-activated mast cells CSK is a negative regulator of degranulation and chemotaxis, but a positive regulator of adhesion to fibronectin and production of proinflammatory cytokines.
    Title: Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.
  9. identified a novel and critical role of c-Src in guiding human neural stem cells differentiation to an oligodendrocyte lineage
    Title: Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src.
  10. CSK is down-regulated in patients with rheumatoid arthritis.
    Title: Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
EBI GWAS Catalog
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of blood pressure and hypertension.
EBI GWAS Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface activates Src kinases, leading to an increase in membrane extensions at the DC surface PubMed
Tat tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell costimulation TAS
Traceable Author Statement
more info
  
involved_in T cell receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of low-density lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tyrosine-protein kinase CSK
Names
C-Src kinase
CSK, non-receptor tyrosine kinase
c-src tyrosine kinase
protein-tyrosine kinase CYL
NP_001120662.1
NP_001341917.1
NP_001374018.1
NP_001374019.1
NP_001374020.1
NP_001374021.1
NP_001374022.1
NP_001374023.1
NP_001374024.1
NP_001374025.1
NP_001374026.1
NP_001374027.1
NP_004374.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127190.2 → NP_001120662.1  tyrosine-protein kinase CSK isoform 1

    See identical proteins and their annotated locations for NP_001120662.1

    Status: REVIEWED

    Source sequence(s)
    AC091230, AK290531, AW575209, AY007162
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Related
    ENSP00000414764.2, ENST00000439220.6
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  2. NM_001354988.2 → NP_001341917.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AK127672, AW575209
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Related
    ENSP00000454906.1, ENST00000567571.5
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  3. NM_001387089.1 → NP_001374018.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  4. NM_001387090.1 → NP_001374019.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  5. NM_001387091.1 → NP_001374020.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  6. NM_001387092.1 → NP_001374021.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  7. NM_001387093.1 → NP_001374022.1  tyrosine-protein kinase CSK isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  8. NM_001387094.1 → NP_001374023.1  tyrosine-protein kinase CSK isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC091230
    UniProtKB/TrEMBL
    B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:187 → 442
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  9. NM_001387095.1 → NP_001374024.1  tyrosine-protein kinase CSK isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC091230
    UniProtKB/TrEMBL
    B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:188 → 442
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

  10. NM_001387096.1 → NP_001374025.1  tyrosine-protein kinase CSK isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC091230
    UniProtKB/TrEMBL
    Q53EL3
    Conserved Domains (3) summary
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    cl21453
    Location:188 → 429
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001387097.1 → NP_001374026.1  tyrosine-protein kinase CSK isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC091230
    UniProtKB/TrEMBL
    A8K3B6, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:155 → 410
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:53 → 142
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:11 → 57
    SH3; Src Homology 3 domain superfamily

  12. NM_001387098.1 → NP_001374027.1  tyrosine-protein kinase CSK isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC091230
    UniProtKB/TrEMBL
    A8K3B6, B5BU52, Q53EL3
    Conserved Domains (3) summary
    cd05082
    Location:145 → 400
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:43 → 132
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cl17036
    Location:11 → 43
    SH3; Src Homology 3 domain superfamily

  13. NM_004383.3 → NP_004374.1  tyrosine-protein kinase CSK isoform 1

    See identical proteins and their annotated locations for NP_004374.1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10269.1
    UniProtKB/Swiss-Prot
    P41240, Q2M3N2, Q6FGZ6
    UniProtKB/TrEMBL
    B2R6Q4, B5BU52, Q53EL3
    Related
    ENSP00000220003.9, ENST00000220003.14
    Conserved Domains (3) summary
    cd05082
    Location:188 → 443
    PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

RNA

  1. NR_170550.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC091230

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74782080..74803197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72651992..72673091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41240.1 GenPept UniProtKB/Swiss-Prot:P41240

Gene LinkOut

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Chemical Information
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