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LAYN layilin [ Homo sapiens (human) ]

Gene ID: 143903, updated on 5-Mar-2024

Summary

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Official Symbol
LAYNprovided by HGNC
Official Full Name
layilinprovided by HGNC
Primary source
HGNC:HGNC:29471
See related
Ensembl:ENSG00000204381 MIM:618843; AllianceGenome:HGNC:29471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables hyaluronic acid binding activity. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary (RPKM 7.0), thyroid (RPKM 6.2) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
11q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111540280..111561745)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111550425..111571891)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111411005..111432470)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 4 Neighboring gene MIR34B and MIR34C host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111410548-111411227 Neighboring gene microRNA 34c Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:111424938-111426137 Neighboring gene Sharpr-MPRA regulatory region 3081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111435687-111436190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3899 Neighboring gene salt inducible kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111563346-111563859 Neighboring gene RN7SK pseudogene 273 Neighboring gene protein phosphatase 2 scaffold subunit Abeta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111594031-111594566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111603371-111604187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:111605768-111606404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:111636139-111637042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis. Cao L, et al. Biomed Res Int, 2022. PMID 36398067, Free PMC Article
  2. LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers. Pan JH, et al. Front Immunol, 2019. PMID 30761122, Free PMC Article
  3. Secretion of inflammatory factors from chondrocytes by layilin signaling. Asano K, et al. Biochem Biophys Res Commun, 2014 Sep 12. PMID 25150153
  4. Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin. Forteza RM, et al. J Biol Chem, 2012 Dec 7. PMID 23048036, Free PMC Article
  5. Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells. Tsutiya A, et al. Biochem Biophys Res Commun, 2021 Apr 16. PMID 33676182

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
    Title: Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status.
  2. Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
    Title: Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer.
  3. ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
    Title: ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis.
  4. Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
    Title: Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells.
  5. Layilin augments integrin activation to promote antitumor immunity.
    Title: Layilin augments integrin activation to promote antitumor immunity.
  6. increased LAYN expression correlates with poor prognosis and increased immune infiltration levels in CD8+ T cells, CD4+ T cells, macrophages, neutrophils and DCs of multiple cancers, especially in colon and gastric cancers.
    Title: LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers.
  7. Renal biopsy samples from patients with glomerulonephritis showed high expression of LAYN in tubular epithelial cells.
    Title: Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells.
  8. results indicate that LAYN would be involved in the enhancement of inflammation and degradation of cartilage in joint diseases such as RA and OA
    Title: Secretion of inflammatory factors from chondrocytes by layilin signaling.
  9. Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.
    Title: Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ30977, FLJ31092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion HDA PubMed 
NOT located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
layilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258390.2 → NP_001245319.1  layilin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001245319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK055539, AK296231, AY358554, DA608521
    Consensus CDS
    CCDS58178.1
    UniProtKB/Swiss-Prot
    A6NJB0, B4DJU0, Q6UX15, Q8TAY8, Q96NC5, Q96NF3
    UniProtKB/TrEMBL
    B4DP26
    Related
    ENSP00000364765.3, ENST00000375615.7
    Conserved Domains (1) summary
    cd03595
    Location:38 → 186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

  2. NM_001258391.2 → NP_001245320.1  layilin isoform 3

    See identical proteins and their annotated locations for NP_001245320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal exons and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055539, AK296231, DA608521, DB006476
    Consensus CDS
    CCDS58179.1
    UniProtKB/Swiss-Prot
    Q6UX15
    Related
    ENSP00000392942.2, ENST00000436913.6

  3. NM_001318799.1 → NP_001305728.1  layilin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK055539, AP002008, DC398135
    UniProtKB/TrEMBL
    B4DDS5
    Conserved Domains (1) summary
    cl02432
    Location:1 → 34
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  4. NM_178834.5 → NP_849156.1  layilin isoform 2 precursor

    See identical proteins and their annotated locations for NP_849156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK055539, AK296231, DA608521
    Consensus CDS
    CCDS31676.1
    UniProtKB/TrEMBL
    B4DP26
    Related
    ENSP00000364764.2, ENST00000375614.7
    Conserved Domains (1) summary
    cd03595
    Location:30 → 178
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    111540280..111561745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718769.5 → XP_006718832.1  layilin isoform X1

    See identical proteins and their annotated locations for XP_006718832.1

    UniProtKB/TrEMBL
    B4DDS5
    Conserved Domains (1) summary
    cl02432
    Location:1 → 34
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    111550425..111571891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367767.1 → XP_054223742.1  layilin isoform X1

    UniProtKB/TrEMBL
    B4DDS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UX15.1 GenPept UniProtKB/Swiss-Prot:Q6UX15

Gene LinkOut

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