MAPK14 mitogen-activated protein kinase 14 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK14provided by HGNC
Official Full Name: mitogen-activated protein kinase 14provided by HGNC
Primary source: HGNC:HGNC:6876
See related: Ensembl:ENSG00000112062 MIM:600289; AllianceGenome:HGNC:6876
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 11.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.31

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (36027808..36124214)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (35848088..35944528)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (35995585..36079013)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic expression of tumor necrosis factor-alpha and evaluation of MAPK-p38 and NFkappaB signaling pathways in autoimmune hepatitis.
Title: Hepatic expression of tumor necrosis factor-α and evaluation of MAPK-p38 and NFκB signaling pathways in autoimmune hepatitis.
Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling.
Title: Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling.
Phosphorylated p38 MAP kinase expression by leucocytes is increased in allergic humans and associated with IgE responses.
Title: Phosphorylated p38 MAP kinase expression by leucocytes is increased in allergic humans and associated with IgE responses.
CXCL13 promotes TNF-alpha synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation.
Title: CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation.
miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
Title: miR-200a-3p regulates epithelial-mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway.
The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
Title: The lncRNA MEG3/miRNA-21/P38MAPK axis inhibits coxsackievirus 3 replication in acute viral myocarditis.
Forkhead box A1 induces angiogenesis through activation of the S100A8/p38 MAPK axis in cutaneous wound healing.
Title: Forkhead box A1 induces angiogenesis through activation of the S100A8/p38 MAPK axis in cutaneous wound healing.
Association of Promoter Methylation Patterns with Expression of MAPK14 in Tissue of Papillary Thyroid Cancer Patients.
Title: Association of Promoter Methylation Patterns with Expression of MAPK14 in Tissue of Papillary Thyroid Cancer Patients.
C-reactive protein impairs immune response of CD8[+] T cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma.
Title: C-reactive protein impairs immune response of CD8(+) T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma.
Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.
Title: Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.

Submit: New GeneRIF Correction See all GeneRIFs (1074)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation	PubMed
	env	HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which activates NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38)	PubMed
	env	HIV-1 gp120-induced release of IL-6 is regulated by p38 MAPK, IkappaBalpha, and p65 NF-kappaB activation in primary human monocyte-derived dendritic cells	PubMed
	env	HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells	PubMed
	env	HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes	PubMed
	env	HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38	PubMed
	env	HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells	PubMed
	env	HIV-1 gp120-mediated enhancement of potassium voltage-gated channel KV1.3 protein is required for microglia neurotoxicity through the p38 MAPK signaling pathway	PubMed
	env	p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41)	PubMed
	env	Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves p38 MAPK signaling pathway	PubMed
	env	HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway	PubMed
	env	Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia	PubMed
	env	HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1	PubMed
	env	Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK)	PubMed
	env	Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB	PubMed
	env	HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity	PubMed
	env	The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120	PubMed
	env	CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK	PubMed
	env	HIV-1 gp120-induced increases in caspase-3 activity, neurite losses and neuronal death are prevented by p38 MAPK, but not c-jun-N-terminal kinase	PubMed
	env	STAT1 associates with p38 MAP kinase in a time-dependent manner after HIV-1 gp120/HCV E2 costimulation in human hepatocytes	PubMed
	env	HCV-E2 and HIV-1 gp120 act collaboratively to trigger a specific set of downstream signaling pathways that include activation of p38 mitogen-activated protein (MAP) kinase and the tyrosine phosphatase, SHP2, in hepatocytes	PubMed
	env	CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not	PubMed
	env	Morphine potentiates HIV-1 gp120-induced neuronal apoptosis, which involves activation of the p38 MAPK cellular signaling pathway	PubMed
Envelope surface glycoprotein gp160, precursor	env	The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells	PubMed
	env	p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41)	PubMed
Nef	nef	HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1	PubMed
	nef	HIV-1 Nef induces phosphorylation of p38 MAPK in M2-type macrophages	PubMed
	nef	Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5	PubMed
	nef	HIV-1 Nef-induced programmed death 1 (PD-1) upregulation requires its proline-rich motif and the activation of the downstream kinase p38	PubMed
	nef	Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter	PubMed
	nef	HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members	PubMed
Tat	tat	HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes	PubMed
	tat	Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10	PubMed
	tat	HIV-1 Tat induces phosphorylation of MAPK14 (p38) in CRT-MG human astroglioma cells	PubMed
	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes	PubMed
	tat	HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes	PubMed
	tat	HIV-1 Tat-mediated upregulation of ICAM-1 expression involves MEK1/2, JNK, and p38 MAPK proteins and downstream IKK2/NF-kappaB signaling pathways	PubMed
	tat	Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING	PubMed
	tat	Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38	PubMed
	tat	Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors	PubMed
	tat	Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes	PubMed
	tat	Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat	PubMed
	tat	HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha	PubMed
	tat	The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production	PubMed
	tat	Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression	PubMed
	tat	HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT)	PubMed
Vpr	vpr	HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr	PubMed
	vpr	HIV-1 Vpr induces IL-6 production via activation of MAPK p38	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20844 (e-PCR)
- UniSTS:36104

A006I20 (e-PCR)
- UniSTS:36105

STS-AA022950 (e-PCR)
- UniSTS:62245

D3S2320 (e-PCR)
- UniSTS:149287

RH37452 (e-PCR)
- UniSTS:73266

STS-L35253 (e-PCR)
- UniSTS:19766

fd03e12.y1 (e-PCR)
- UniSTS:194881

RH80957 (e-PCR)
- UniSTS:86868

RH17930 (e-PCR)
- UniSTS:85352

RH46846 (e-PCR)
- UniSTS:41663

D6S1210E (e-PCR)
- UniSTS:15040

RH120022 (e-PCR)
- UniSTS:133346

MAPK14_184 (e-PCR)
- UniSTS:277476

D6S1848 (e-PCR)
- UniSTS:81131

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables NFAT protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase p38 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	TAS Traceable Author Statement more info	PubMed
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in cartilage condensation	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to UV-B	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipoteichoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular senescence	TAS Traceable Author Statement more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in glucose import	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to antigenic stimulus	TAS Traceable Author Statement more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in p38MAPK cascade	TAS Traceable Author Statement more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in placenta development	IEA Inferred from Electronic Annotation more info
involved_in platelet activation	TAS Traceable Author Statement more info
NOT involved_in positive regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle cell differentiation	TAS Traceable Author Statement more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
involved_in response to muscle stretch	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-activated protein kinase signaling cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-induced premature senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule lumen	TAS Traceable Author Statement more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase 14

Names: CSAID-binding protein; MAP kinase 14; MAP kinase Mxi2; MAP kinase p38 alpha; MAX-interacting protein 2; cytokine suppressive anti-inflammatory drug binding protein; mitogen-activated protein kinase p38 alpha; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; stress-activated protein kinase 2A

NP_001306.1

EC 2.7.11.24

NP_620581.1

EC 2.7.11.24

NP_620582.1

EC 2.7.11.24

NP_620583.1

EC 2.7.11.24

XP_006715061.1

EC 2.7.11.24

XP_011512612.2

EC 2.7.11.24

XP_016865788.1

EC 2.7.11.24

XP_016865789.1

EC 2.7.11.24

XP_047274188.1

EC 2.7.11.24

XP_047274189.1

EC 2.7.11.24

XP_047274190.1

EC 2.7.11.24

XP_047274191.1

EC 2.7.11.24

XP_047274192.1

EC 2.7.11.24

XP_047274193.1

EC 2.7.11.24

XP_054210307.1

EC 2.7.11.24

XP_054210308.1

EC 2.7.11.24

XP_054210309.1

EC 2.7.11.24

XP_054210310.1

EC 2.7.11.24

XP_054210311.1

EC 2.7.11.24

XP_054210312.1

EC 2.7.11.24

XP_054210313.1

EC 2.7.11.24

XP_054210314.1

EC 2.7.11.24

XP_054210315.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001315.3 → NP_001306.1 mitogen-activated protein kinase 14 isoform 1

See identical proteins and their annotated locations for NP_001306.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

L35263, Z95152

Consensus CDS

CCDS4815.1

UniProtKB/TrEMBL

L7RSM2

Related

ENSP00000229795.3, ENST00000229795.8

Conserved Domains (1) summary

cd07877
Location:6 → 350

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
NM_139012.3 → NP_620581.1 mitogen-activated protein kinase 14 isoform 2

See identical proteins and their annotated locations for NP_620581.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1.

Source sequence(s)

AF100544, DA438432, Z95152

Consensus CDS

CCDS4816.1

UniProtKB/Swiss-Prot

A6ZJ92, A8K6P4, B0LPH0, B5TY32, O60776, Q13083, Q14084, Q16539, Q8TDX0

Related

ENSP00000229794.4, ENST00000229794.9

Conserved Domains (1) summary

cd07877
Location:6 → 350

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
NM_139013.3 → NP_620582.1 mitogen-activated protein kinase 14 isoform 3

See identical proteins and their annotated locations for NP_620582.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal segment, and a distinct C-terminus, as compared to isoform 1.

Source sequence(s)

DA438432, U19775, Z95152

UniProtKB/Swiss-Prot

Q16539

Conserved Domains (2) summary

smart00220
Location:24 → 262

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:6 → 281

PKc_like; Protein Kinases, catalytic domain
NM_139014.3 → NP_620583.1 mitogen-activated protein kinase 14 isoform 4

See identical proteins and their annotated locations for NP_620583.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1.

Source sequence(s)

AB074150, DA438432, Z95152

Consensus CDS

CCDS4817.1

UniProtKB/Swiss-Prot

Q16539

Related

ENSP00000308669.4, ENST00000310795.8

Conserved Domains (1) summary

cl21453
Location:6 → 257

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

36027808..36124214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010299.3 → XP_016865788.1 mitogen-activated protein kinase 14 isoform X6
XM_017010300.3 → XP_016865789.1 mitogen-activated protein kinase 14 isoform X5
XM_047418233.1 → XP_047274189.1 mitogen-activated protein kinase 14 isoform X3
XM_047418235.1 → XP_047274191.1 mitogen-activated protein kinase 14 isoform X9
XM_047418234.1 → XP_047274190.1 mitogen-activated protein kinase 14 isoform X4
XM_011514310.4 → XP_011512612.2 mitogen-activated protein kinase 14 isoform X1
XM_047418232.1 → XP_047274188.1 mitogen-activated protein kinase 14 isoform X2
XM_047418236.1 → XP_047274192.1 mitogen-activated protein kinase 14 isoform X7
XM_047418237.1 → XP_047274193.1 mitogen-activated protein kinase 14 isoform X8

UniProtKB/TrEMBL

B4E0K5
XM_006714998.4 → XP_006715061.1 mitogen-activated protein kinase 14 isoform X8

See identical proteins and their annotated locations for XP_006715061.1

UniProtKB/TrEMBL

B4E0K5

Related

ENSP00000419837.1, ENST00000468133.5

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain

RNA

XR_007059209.1 RNA Sequence
XR_007059210.1 RNA Sequence
XR_007059211.1 RNA Sequence
XR_926065.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

35848088..35944528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354332.1 → XP_054210307.1 mitogen-activated protein kinase 14 isoform X1
XM_054354333.1 → XP_054210308.1 mitogen-activated protein kinase 14 isoform X2
XM_054354337.1 → XP_054210312.1 mitogen-activated protein kinase 14 isoform X6
XM_054354336.1 → XP_054210311.1 mitogen-activated protein kinase 14 isoform X5
XM_054354334.1 → XP_054210309.1 mitogen-activated protein kinase 14 isoform X3
XM_054354335.1 → XP_054210310.1 mitogen-activated protein kinase 14 isoform X4
XM_054354338.1 → XP_054210313.1 mitogen-activated protein kinase 14 isoform X7
XM_054354340.1 → XP_054210315.1 mitogen-activated protein kinase 14 isoform X10
XM_054354339.1 → XP_054210314.1 mitogen-activated protein kinase 14 isoform X8

UniProtKB/TrEMBL

B4E0K5