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ASB5 ankyrin repeat and SOCS box containing 5 [ Homo sapiens (human) ]

Gene ID: 140458, updated on 5-Mar-2024

Summary

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Official Symbol
ASB5provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 5provided by HGNC
Primary source
HGNC:HGNC:17180
See related
Ensembl:ENSG00000164122 MIM:615050; AllianceGenome:HGNC:17180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASB-5
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 5.3), urinary bladder (RPKM 4.0) and 6 other tissues See more
Orthologs
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Genomic context

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Location:
4q34.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (176213673..176277524, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (179552031..179616715, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177134824..177190373, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900182 Neighboring gene WD repeat domain 17 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:177077413-177078612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76272 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76278 Neighboring gene spermatogenesis associated 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76283 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76286 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76293 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76294 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:177240928-177241428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15817 Neighboring gene SPCS3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22166 Neighboring gene NANOG hESC enhancer GRCh37_chr4:177278841-177279359 Neighboring gene signal peptidase complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22168 Neighboring gene uncharacterized LOC124900817

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action. Liu P, et al. Trends Biochem Sci, 2019 Jan. PMID 30446376
  2. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
  3. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 5
Names
SOCS box protein ASB-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410863.1 → NP_001397792.1  ankyrin repeat and SOCS box protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093605
    Consensus CDS
    CCDS93672.1
    UniProtKB/TrEMBL
    A0A5F9ZHS2
    Related
    ENSP00000500617.1, ENST00000672074.1

  2. NM_080874.4 → NP_543150.1  ankyrin repeat and SOCS box protein 5 isoform 1

    See identical proteins and their annotated locations for NP_543150.1

    Status: REVIEWED

    Source sequence(s)
    AC093605, BX647857
    Consensus CDS
    CCDS3827.1
    UniProtKB/Swiss-Prot
    Q8N7B5, Q8WWX0
    UniProtKB/TrEMBL
    Q5HYF3
    Related
    ENSP00000296525.3, ENST00000296525.7
    Conserved Domains (3) summary
    cd00204
    Location:71 → 188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:288 → 329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    176213673..176277524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262759.2 → XP_005262816.1  ankyrin repeat and SOCS box protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005262816.1

    UniProtKB/Swiss-Prot
    Q8N7B5, Q8WWX0
    UniProtKB/TrEMBL
    Q5HYF3
    Conserved Domains (3) summary
    cd00204
    Location:71 → 188
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03724
    Location:288 → 329
    SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
    sd00045
    Location:71 → 100
    ANK; ANK repeat [structural motif]

  2. XM_011531617.4 → XP_011529919.1  ankyrin repeat and SOCS box protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011529919.1

    UniProtKB/Swiss-Prot
    Q8WWX0
    Related
    ENSP00000422877.1, ENST00000512254.1
    Conserved Domains (3) summary
    cd00204
    Location:18 → 135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:18 → 47
    ANK; ANK repeat [structural motif]
    cl02533
    Location:235 → 276
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    179552031..179616715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348969.1 → XP_054204944.1  ankyrin repeat and SOCS box protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8N7B5, Q8WWX0
    UniProtKB/TrEMBL
    Q5HYF3

  2. XM_054348970.1 → XP_054204945.1  ankyrin repeat and SOCS box protein 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WWX0.1 GenPept UniProtKB/Swiss-Prot:Q8WWX0

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