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CPN2 carboxypeptidase N subunit 2 [ Homo sapiens (human) ]

Gene ID: 1370, updated on 5-Mar-2024

Summary

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Official Symbol
CPN2provided by HGNC
Official Full Name
carboxypeptidase N subunit 2provided by HGNC
Primary source
HGNC:HGNC:2313
See related
Ensembl:ENSG00000178772 MIM:603104; AllianceGenome:HGNC:2313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACBP
Summary
Predicted to be involved in regulation of catalytic activity. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver (RPKM 60.4) See more
Orthologs
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Genomic context

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See CPN2 in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194339768..194351328, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197038329..197049487, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194060497..194072057, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:193994438-193995637 Neighboring gene long intergenic non-protein coding RNA 2048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194000115-194000616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194000617-194001116 Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194033347-194033847 Neighboring gene Sharpr-MPRA regulatory region 2488 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:194039992-194041191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194057362-194058242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194059168-194059834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194071533-194072382 Neighboring gene leucine rich repeat containing 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194089931-194090895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15021 Neighboring gene glycoprotein V platelet

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of Carboxypeptidase N Invasion and Migration in Breast Cancer. Cui R, et al. Anticancer Agents Med Chem, 2016. PMID 26860443
  2. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. Tan F, et al. J Biol Chem, 1990 Jan 5. PMID 2378615
  3. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. Skidgel RA, et al. Biochem Biophys Res Commun, 1988 Aug 15. PMID 3408501
  4. Carboxypeptidase N: a pleiotropic regulator of inflammation. Matthews KW, et al. Mol Immunol, 2004 Jan. PMID 14687935
  5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). Riley DA, et al. Genomics, 1998 May 15. PMID 9628828

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of carboxypeptidase N, polypeptide 2 (CPN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein stabilization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase N subunit 2
Names
carboxypeptidase N 83 kDa chain
carboxypeptidase N large subunit
carboxypeptidase N regulatory subunit
carboxypeptidase N, polypeptide 2, 83kD
NP_001073982.3
NP_001278917.1
XP_005269337.1
XP_054201277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080513.4 → NP_001073982.3  carboxypeptidase N subunit 2 precursor

    See identical proteins and their annotated locations for NP_001073982.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC174158
    Consensus CDS
    CCDS33920.1
    UniProtKB/Swiss-Prot
    B2RPE7, P22792, Q86SU4, Q8N5V4
    Related
    ENSP00000319464.3, ENST00000323830.4
    Conserved Domains (6) summary
    smart00013
    Location:21 → 53
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395 → 446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149 → 356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387 → 399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123 → 146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294 → 349
    LRR_8; Leucine rich repeat

  2. NM_001291988.2 → NP_001278917.1  carboxypeptidase N subunit 2 precursor

    See identical proteins and their annotated locations for NP_001278917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC174158
    Consensus CDS
    CCDS33920.1
    UniProtKB/Swiss-Prot
    B2RPE7, P22792, Q86SU4, Q8N5V4
    Related
    ENSP00000402232.1, ENST00000429275.1
    Conserved Domains (6) summary
    smart00013
    Location:21 → 53
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395 → 446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149 → 356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387 → 399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123 → 146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294 → 349
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    194339768..194351328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269280.5 → XP_005269337.1  carboxypeptidase N subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_005269337.1

    UniProtKB/Swiss-Prot
    B2RPE7, P22792, Q86SU4, Q8N5V4
    Conserved Domains (6) summary
    smart00013
    Location:21 → 53
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395 → 446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149 → 356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387 → 399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123 → 146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294 → 349
    LRR_8; Leucine rich repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    197038329..197049487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345302.1 → XP_054201277.1  carboxypeptidase N subunit 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001309.1: Suppressed sequence

    Description
    NM_001309.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22792.3 GenPept UniProtKB/Swiss-Prot:P22792

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