U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADORA2B adenosine A2b receptor [ Homo sapiens (human) ]

Gene ID: 136, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ADORA2Bprovided by HGNC
Official Full Name
adenosine A2b receptorprovided by HGNC
Primary source
HGNC:HGNC:264
See related
Ensembl:ENSG00000170425 MIM:600446; AllianceGenome:HGNC:264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADORA2
Summary
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15850362..15975746)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15756782..15877924)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15848444..15879060)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr17:15716437-15716999 Neighboring gene long intergenic non-protein coding RNA 2087 Neighboring gene Sharpr-MPRA regulatory region 5503 Neighboring gene uncharacterized LOC105371557 Neighboring gene LCR17pA recombination region Neighboring gene SPECC1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15760104-15761059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15761456-15762052 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:15762053-15762649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15785055-15785554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15831280-15831780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15831781-15832281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15848447-15849261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15854153-15854950 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15869033-15869619 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15869620-15870205 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15870793-15871377 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15870206-15870792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15871628-15872376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15872377-15873123 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15881867-15882452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:15882453-15883039 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15885417-15886106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11746 Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene MPRA-validated peak2750 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8215 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene Sharpr-MPRA regulatory region 10193 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15947413-15947923 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15947924-15948433 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 11 Neighboring gene nuclear receptor corepressor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer. Strickland LN, et al. Front Immunol, 2023. PMID 37187740, Free PMC Article
  2. Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells. Campos-Contreras ADR, et al. Int J Mol Sci, 2022 Apr 21. PMID 35562985, Free PMC Article
  3. Insulin requires A(2B) adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia. Salsoso R, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Jan 1. PMID 33096224
  4. Tumor-derived exosomes promote angiogenesis via adenosine A(2B) receptor signaling. Ludwig N, et al. Angiogenesis, 2020 Nov. PMID 32419057, Free PMC Article
  5. Characterization of cancer-related somatic mutations in the adenosine A(2B) receptor. Wang X, et al. Eur J Pharmacol, 2020 Aug 5. PMID 32348778

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by gamma-Ray Irradiation.
    Title: Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by γ-Ray Irradiation.
  2. The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer.
    Title: The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer.
  3. CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
    Title: CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
  4. Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells.
    Title: Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells.
  5. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
    Title: Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
  6. Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling.
    Title: Tumor-derived exosomes promote angiogenesis via adenosine A(2B) receptor signaling.
  7. Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
    Title: Involvement of CD73 and A2B Receptor in Radiation-Induced DNA Damage Response and Cell Migration in Human Glioblastoma A172 Cells.
  8. Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway Stimulation by Regulating GSK3b Activity.
    Title: Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/β-Catenin Pathway Stimulation by Regulating GSK3b Activity.
  9. Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
    Title: Systematic deletion of adenosine receptors reveals novel roles in inflammation and pyroptosis in THP-1 macrophages.
  10. Insulin requires A2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.
    Title: Insulin requires A(2B) adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chronic inflammatory response to non-antigenic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in relaxation of vascular associated smooth muscle IEA
Inferred from Electronic Annotation
more info
  
involved_in vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenosine receptor A2b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000676.4 → NP_000667.1  adenosine receptor A2b

    See identical proteins and their annotated locations for NP_000667.1

    Status: VALIDATED

    Source sequence(s)
    AC006251
    Consensus CDS
    CCDS11173.1
    UniProtKB/Swiss-Prot
    P29275
    Related
    ENSP00000304501.2, ENST00000304222.3
    Conserved Domains (1) summary
    cd15069
    Location:8 → 301
    7tmA_Adenosine_R_A2B; adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    15850362..15975746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435373.1 → XP_047291329.1  adenosine receptor A2b isoform X2

  2. XM_047435374.1 → XP_047291330.1  adenosine receptor A2b isoform X2

  3. XM_011523659.4 → XP_011521961.1  adenosine receptor A2b isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:6 → 187
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. XM_047435375.1 → XP_047291331.1  adenosine receptor A2b isoform X3

  5. XM_011523661.3 → XP_011521963.1  adenosine receptor A2b isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:10 → 34
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:8 → 112
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_017024197.3 → XP_016879686.1  adenosine receptor A2b isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    15756782..15877924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315090.1 → XP_054171065.1  adenosine receptor A2b isoform X2

  2. XM_054315091.1 → XP_054171066.1  adenosine receptor A2b isoform X2

  3. XM_054315092.1 → XP_054171067.1  adenosine receptor A2b isoform X2

  4. XM_054315093.1 → XP_054171068.1  adenosine receptor A2b isoform X3

  5. XM_054315094.1 → XP_054171069.1  adenosine receptor A2b isoform X4

  6. XM_054315089.1 → XP_054171064.1  adenosine receptor A2b isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29275.1 GenPept UniProtKB/Swiss-Prot:P29275

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous