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UBLCP1 ubiquitin like domain containing CTD phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 134510, updated on 5-Mar-2024

Summary

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Official Symbol
UBLCP1provided by HGNC
Official Full Name
ubiquitin like domain containing CTD phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:28110
See related
Ensembl:ENSG00000164332 MIM:609867; AllianceGenome:HGNC:28110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPUB1
Summary
Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 19.2), brain (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

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See UBLCP1 in Genome Data Viewer
Location:
5q33.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159263290..159286036)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (159791779..159814534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (158690298..158713044)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 145 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158634672-158635327 Neighboring gene uncharacterized LOC107986468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23544 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene long intergenic non-protein coding RNA 1932 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158689523-158690030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:158690031-158690538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:158728900-158730099 Neighboring gene uncharacterized LOC105377683 Neighboring gene RNA, U4atac small nuclear 2, pseudogene Neighboring gene interleukin 12B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Zheng H, et al. Biochem Biophys Res Commun, 2005 Jun 17. PMID 15883030
  2. Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Liu X, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31843888, Free PMC Article
  3. Solution structure and Rpn1 interaction of the UBL domain of human RNA polymerase II C-terminal domain phosphatase. Yun JH, et al. PLoS One, 2013. PMID 23667555, Free PMC Article
  4. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
  5. UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes. Ge Y, et al. J Immunol, 2019 Dec 1. PMID 31659016, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity.
    Title: A novel autism-associated UBLCP1 mutation impacts proteasome regulation/activity.
  2. Study provides evidence that Rpn1-Ser361 is a prevalent phosphosite that is required for proper assembly and activity of the 26S proteasome and identified multiple kinases, including PIM1/2/3, that can phosphorylate Rpn1-S361 and have demonstrated that UBLCP1 is a physiologically relevant phosphatase of this site. Blocking phosphorylation of Rpn1-S361 leads to slowed proliferation and mitochondrial dysfunction.
    Title: Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.
  3. Data show that UBLCP1 selectively binds to the 26S proteasome non-ATPase regulatory subunit 13 (19S regulatory particle) in regulating proteasome assembly.
    Title: Phosphatase UBLCP1 controls proteasome assembly.
  4. the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1
    Title: Solution structure and Rpn1 interaction of the UBL domain of human RNA polymerase II C-terminal domain phosphatase.
  5. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity
    Title: UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25267, MGC10067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome regulatory particle binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of proteasome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-like domain-containing CTD phosphatase 1
Names
CTD phosphatase-like with ubiquitin domain 1
CTD-like phosphatase domain-containing protein
nuclear proteasome inhibitor UBLCP1
NP_659486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145049.5 → NP_659486.2  ubiquitin-like domain-containing CTD phosphatase 1

    See identical proteins and their annotated locations for NP_659486.2

    Status: VALIDATED

    Source sequence(s)
    AC011418, AY444562, DA930581
    Consensus CDS
    CCDS4345.1
    UniProtKB/Swiss-Prot
    D3DQJ7, Q8WVY7, Q96DK5
    Related
    ENSP00000296786.6, ENST00000296786.8
    Conserved Domains (2) summary
    TIGR02245
    Location:117 → 311
    HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
    cd01813
    Location:3 → 77
    Ubl_UBLCP1; ubiquitin-like (Ubl) domain found in ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    159263290..159286036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    159791779..159814534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WVY7.2 GenPept UniProtKB/Swiss-Prot:Q8WVY7

Gene LinkOut

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