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H1-8 H1.8 linker histone [ Homo sapiens (human) ]

Gene ID: 132243, updated on 7-Apr-2024

Summary

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Official Symbol
H1-8provided by HGNC
Official Full Name
H1.8 linker histoneprovided by HGNC
Primary source
HGNC:HGNC:18463
See related
Ensembl:ENSG00000178804 AllianceGenome:HGNC:18463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1.8; H1oo; osH1; H1FOO
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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Location:
3q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129543175..129551467)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132287585..132295894)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129262018..129270310)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20517 Neighboring gene Sharpr-MPRA regulatory region 8693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129168229-129168945 Neighboring gene intraflagellar transport 122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129200162-129201039 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:129208521-129208729 Neighboring gene Sharpr-MPRA regulatory region 10640 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:129213542-129214741 Neighboring gene MPRA-validated peak4826 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129247433-129248158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129248159-129248884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129253999-129254668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129261557-129262058 Neighboring gene Sharpr-MPRA regulatory region 2951 Neighboring gene rhodopsin enhancer region Neighboring gene rhodopsin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129277154-129278043 Neighboring gene plexin D1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129291899-129292624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129295530-129296256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129315061-129315792 Neighboring gene RNA, 7SL, cytoplasmic 752, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129321778-129322770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129323763-129324755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129325748-129326740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129326741-129327731 Neighboring gene uncharacterized LOC124909431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129330613-129331535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129331536-129332457 Neighboring gene Sharpr-MPRA regulatory region 12201

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization. Mizusawa Y, et al. Fertil Steril, 2010 Mar 1. PMID 19147139
  2. Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer. Teranishi T, et al. Dev Biol, 2004 Feb 1. PMID 14729479
  3. Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte. Tanaka Y, et al. Biochem Biophys Res Commun, 2003 May 2. PMID 12711322
  4. H1FOO is coupled to the initiation of oocytic growth. Tanaka M, et al. Biol Reprod, 2005 Jan. PMID 15371275
  5. Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice. Gao S, et al. Dev Biol, 2004 Feb 1. PMID 14729478

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. After intracytoplasmic sperm injection, the assembly of H1FOO on sperm chromatin during decondensation seems to occur very quickly, and hH1FOO protein is localized in all oocytes from primordial to Graafian follicles.
    Title: Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization.
  2. Structure and gene expression of osH1.
    Title: Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC50807

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosomal DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epigenetic regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
NOT located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
histone H1.8
Names
H1 histone family member O oocyte specific
histone H1oo
oocyte-specific histone H1
oocyte-specific linker histone H1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308262.2 → NP_001295191.1  histone H1.8 isoform 2

    See identical proteins and their annotated locations for NP_001295191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons and contains an alternate 5' terminal exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC047943, BM564157
    Consensus CDS
    CCDS77815.1
    UniProtKB/Swiss-Prot
    Q8IZA3
    Related
    ENSP00000422964.1, ENST00000503977.1
    Conserved Domains (1) summary
    PRK12373
    Location:7 → 93
    PRK12373; NADH dehydrogenase subunit E; Provisional

  2. NM_153833.3 → NP_722575.1  histone H1.8 isoform 1

    See identical proteins and their annotated locations for NP_722575.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC080007
    Consensus CDS
    CCDS3064.1
    UniProtKB/Swiss-Prot
    Q86WT7, Q8IZA3
    Related
    ENSP00000319799.2, ENST00000324382.7
    Conserved Domains (1) summary
    cd00073
    Location:49 → 139
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    129543175..129551467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005733.2 → XP_016861222.1  histone H1.8 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZA3
    Conserved Domains (1) summary
    PRK12373
    Location:7 → 93
    PRK12373; NADH dehydrogenase subunit E; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    132287585..132295894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345295.1 → XP_054201270.1  histone H1.8 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZA3.1 GenPept UniProtKB/Swiss-Prot:Q8IZA3

Gene LinkOut

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