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SPATA3 spermatogenesis associated 3 [ Homo sapiens (human) ]

Gene ID: 130560, updated on 5-Mar-2024

Summary

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Official Symbol
SPATA3provided by HGNC
Official Full Name
spermatogenesis associated 3provided by HGNC
Primary source
HGNC:HGNC:17884
See related
Ensembl:ENSG00000173699 MIM:619857; AllianceGenome:HGNC:17884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSARG1
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 15.8) See more
Orthologs
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Genomic context

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Location:
2q37.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230996121..231020109)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (231479391..231504484)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231860836..231872755)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 55 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17269 Neighboring gene COX20 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17272 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231850196-231850380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:231851885-231852384 Neighboring gene SPATA3 antisense RNA 1 (head to head) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231860347-231860880 Neighboring gene uncharacterized LOC112268432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17274 Neighboring gene chromosome 2 open reading frame 72 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12423 Neighboring gene proteasome 26S subunit, non-ATPase 1 Neighboring gene 5-hydroxytryptamine receptor 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Molecular cloning for testis spermatogenesis cell apoptosis related gene TSARG1 and Mtsarg1 and expression analysis for Mtsarg1 gene]. Fu JJ, et al. Yi Chuan Xue Bao, 2003 Jan. PMID 12812072
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 3
Names
testis and spermatogenesis cell apoptosis related gene 1
testis and spermatogenesis cell-related protein 1
testis spermatocyte apoptosis-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139073.5 → NP_620712.2  spermatogenesis-associated protein 3

    See identical proteins and their annotated locations for NP_620712.2

    Status: VALIDATED

    Source sequence(s)
    AC105344
    Consensus CDS
    CCDS2481.1
    UniProtKB/Swiss-Prot
    Q86WX5, Q8N9Y6, Q8NHX4
    Related
    ENSP00000403804.2, ENST00000433428.7
    Conserved Domains (2) summary
    pfam12238
    Location:18 → 56
    MSA-2c; Merozoite surface antigen 2c
    pfam15662
    Location:1 → 191
    SPATA3; Spermatogenesis-associated protein 3 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    230996121..231020109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443398.1 → XP_047299354.1  spermatogenesis-associated protein 3 isoform X1

  2. XM_017003363.3 → XP_016858852.1  spermatogenesis-associated protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WX5, Q8N9Y6, Q8NHX4
    Related
    ENSP00000388741.1, ENST00000455816.1
    Conserved Domains (2) summary
    pfam12238
    Location:18 → 56
    MSA-2c; Merozoite surface antigen 2c
    pfam15662
    Location:1 → 191
    SPATA3; Spermatogenesis-associated protein 3 family

  3. XM_047443397.1 → XP_047299353.1  spermatogenesis-associated protein 3 isoform X1

  4. XM_005246303.3 → XP_005246360.1  spermatogenesis-associated protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005246360.1

    UniProtKB/Swiss-Prot
    Q86WX5, Q8N9Y6, Q8NHX4
    Conserved Domains (2) summary
    pfam12238
    Location:18 → 56
    MSA-2c; Merozoite surface antigen 2c
    pfam15662
    Location:1 → 191
    SPATA3; Spermatogenesis-associated protein 3 family

RNA

  1. XR_007069642.1 RNA Sequence

  2. XR_007069640.1 RNA Sequence

  3. XR_001738624.3 RNA Sequence

  4. XR_001738628.2 RNA Sequence

  5. XR_002959241.2 RNA Sequence

  6. XR_001738627.3 RNA Sequence

  7. XR_007069639.1 RNA Sequence

  8. XR_922856.3 RNA Sequence

  9. XR_007069641.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    231479391..231504484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340544.1 → XP_054196519.1  spermatogenesis-associated protein 3 isoform X1

  2. XM_054340546.1 → XP_054196521.1  spermatogenesis-associated protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WX5, Q8N9Y6, Q8NHX4

  3. XM_054340543.1 → XP_054196518.1  spermatogenesis-associated protein 3 isoform X1

  4. XM_054340545.1 → XP_054196520.1  spermatogenesis-associated protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q86WX5, Q8N9Y6, Q8NHX4

RNA

  1. XR_008486276.1 RNA Sequence

  2. XR_008486277.1 RNA Sequence

  3. XR_008486278.1 RNA Sequence

  4. XR_008486281.1 RNA Sequence

  5. XR_008486282.1 RNA Sequence

  6. XR_008486279.1 RNA Sequence

  7. XR_008486275.1 RNA Sequence

  8. XR_008486280.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHX4.2 GenPept UniProtKB/Swiss-Prot:Q8NHX4

Gene LinkOut

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