SLX4IP SLX4 interacting protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLX4IPprovided by HGNC
Official Full Name: SLX4 interacting proteinprovided by HGNC
Primary source: HGNC:HGNC:16225
See related: Ensembl:ENSG00000149346 MIM:615958; AllianceGenome:HGNC:16225
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C20orf94; bA204H22.1; bA254M13.1; dJ1099D15.3
Expression: Ubiquitous expression in skin (RPKM 1.0), testis (RPKM 0.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20p12.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (10435305..10628030)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (10478114..10671152)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (10415953..10608678)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization.
Title: SLX4IP Promotes Telomere Maintenance in Androgen Receptor-Independent Castration-Resistant Prostate Cancer through ALT-like Telomeric PML Localization.
SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness.
Title: SLX4IP and telomere dynamics dictate breast cancer metastasis and therapeutic responsiveness.
SLX4IP antagonizes promiscuous BLM Activity during alternative lengthening of telomeres maintenance in osteosarcoma cells.
Title: SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.
The binding of SLX4IP to both SLX4 and XPF-ERCC1 not only is vital for maintaining the stability of SLX4IP protein, but also promotes the interaction between SLX4 and XPF-ERCC1, especially after DNA damage. Collectively, these results demonstrate a new regulatory role for SLX4IP in maintaining an efficient SLX4-XPF-ERCC1 complex in interstrand crosslinks (ICLs) repair.
Title: SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.
The association of SLX4IP deletion with male sex suggest that differential illegitimate V(D)J-mediated recombination events contribute to the higher incidence rates of childhood acute lymphoblastic leukemia in boys compared with girls.
Title: Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.
C20orf94 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr interacts with TSPYL1 and C20orf94 subunits of the SLX4 complex in Vpr-expressing THP-1 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-58236 (e-PCR)
- UniSTS:64776

G32695 (e-PCR)
- UniSTS:117277

A009N48 (e-PCR)
- UniSTS:68128

D20S507 (e-PCR)
- UniSTS:150308

AL034503 (e-PCR)
- UniSTS:94255

SHGC-107167 (e-PCR)
- UniSTS:170294

AL034512 (e-PCR)
- UniSTS:94264

SHGC-79893 (e-PCR)
- UniSTS:101464

SHGC-79896 (e-PCR)
- UniSTS:101465

D20S160 (e-PCR)
- UniSTS:12977

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: protein SLX4IP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.