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PROKR2 prokineticin receptor 2 [ Homo sapiens (human) ]

Gene ID: 128674, updated on 11-Apr-2024

Summary

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Official Symbol
PROKR2provided by HGNC
Official Full Name
prokineticin receptor 2provided by HGNC
Primary source
HGNC:HGNC:15836
See related
Ensembl:ENSG00000101292 MIM:607123; AllianceGenome:HGNC:15836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH3; KAL3; PKR2; GPRg2; GPR73b; GPR73L1; dJ680N4.3
Summary
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
20p12.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (5299218..5316954, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (5339785..5357889, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5279864..5297600, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:5107325-5107826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113215-5113716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5113717-5114216 Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:5150939-5151438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17515 Neighboring gene Sharpr-MPRA regulatory region 2649 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:5156307-5156942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17517 Neighboring gene meiotic recombination hotspot R Neighboring gene OCT4 hESC enhancer GRCh37_chr20:5246300-5246801 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 1 Neighboring gene RNA, 5.8S ribosomal pseudogene 7 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:5376502-5377701 Neighboring gene reporter assay-validated silencer 4 Neighboring gene long intergenic non-protein coding RNA 658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism. Wang X, et al. Hum Mol Genet, 2023 May 5. PMID 36694982, Free PMC Article
  2. [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism]. Xie YD, et al. Zhonghua Nei Ke Za Zhi, 2022 Aug 1. PMID 35922219
  3. Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review. Sugisawa C, et al. Endocr J, 2022 Jul 28. PMID 35236788
  4. Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress. Song YB, et al. Proc Natl Acad Sci U S A, 2022 Feb 22. PMID 35173048, Free PMC Article
  5. Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty. Aiello F, et al. Ital J Pediatr, 2021 Jan 7. PMID 33413516, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.
    Title: PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency.
  2. Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.
    Title: Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.
  3. A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.
    Title: A functional spectrum of PROKR2 mutations identified in isolated hypogonadotropic hypogonadism.
  4. Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
    Title: Biallelic PROKR2 variants and congenital hypogonadotropic hypogonadism: a case report and a literature review.
  5. [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].
    Title: [Analysis of PROKR2 gene mutation in patients with hypogonadotropic hypogonadism].
  6. Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.
    Title: Trafficking-defective mutant PROKR2 cycles between endoplasmic reticulum and Golgi to attenuate endoplasmic reticulum stress.
  7. Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.
    Title: Comparison of Clinical Characteristics and Spermatogenesis in CHH Patients Caused by PROKR2 and FGFR1 Mutations.
  8. Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
    Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
  9. Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.
    Title: Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers.
  10. Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty.
    Title: Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty.
Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
prokineticin receptor 2
Names
G protein-coupled receptor 73-like 1
G-protein coupled receptor I5E
PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008132.2 RefSeqGene

    Range
    2638..18170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144773.4 → NP_658986.1  prokineticin receptor 2

    See identical proteins and their annotated locations for NP_658986.1

    Status: REVIEWED

    Source sequence(s)
    AL121755, AL121757
    Consensus CDS
    CCDS13089.1
    UniProtKB/Swiss-Prot
    A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
    UniProtKB/TrEMBL
    A8K1T0
    Related
    ENSP00000504128.1, ENST00000678254.1
    Conserved Domains (1) summary
    cd15204
    Location:54 → 344
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    5299218..5316954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027646.2 → XP_016883135.1  prokineticin receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
    UniProtKB/TrEMBL
    A8K1T0
    Conserved Domains (1) summary
    cd15204
    Location:54 → 344
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    5339785..5357889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322965.1 → XP_054178940.1  prokineticin receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    A5JUU1, Q2M3C0, Q5TDY1, Q8NFJ6, Q9NTT0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFJ6.1 GenPept UniProtKB/Swiss-Prot:Q8NFJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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