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ZNF831 zinc finger protein 831 [ Homo sapiens (human) ]

Gene ID: 128611, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF831provided by HGNC
Official Full Name
zinc finger protein 831provided by HGNC
Primary source
HGNC:HGNC:16167
See related
Ensembl:ENSG00000124203 AllianceGenome:HGNC:16167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf174
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 2.3), spleen (RPKM 1.1) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
20q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (59123388..59259113)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (60906490..61042393)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57698443..57834168)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904943 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:57638504-57639703 Neighboring gene NANOG hESC enhancer GRCh37_chr20:57681118-57681619 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:57697082-57697631 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:57724967-57725189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57734401-57735226 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:57770614-57771813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57893004-57893504 Neighboring gene Sharpr-MPRA regulatory region 9189 Neighboring gene endothelin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57950919-57951420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57979490-57979990 Neighboring gene NANOG hESC enhancer GRCh37_chr20:58013205-58013760 Neighboring gene piezo type mechanosensitive ion channel component 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomewide association study of movement-related adverse antipsychotic effects. Aberg K, et al. Biol Psychiatry, 2010 Feb 1. PMID 19875103, Free PMC Article
  2. Genome-wide association study of blood pressure and hypertension. Levy D, et al. Nat Genet, 2009 Jun. PMID 19430479, Free PMC Article
  3. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. International Consortium for Blood Pressure Genome-Wide Association Studies, et al. Nature, 2011 Sep 11. PMID 21909115, Free PMC Article
  4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV, et al. Nat Genet, 2011 Sep 11. PMID 21909110, Free PMC Article
  5. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of blood pressure and hypertension.
EBI GWAS Catalog
Genomewide association study of movement-related adverse antipsychotic effects.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 831 (ZNF831; C20orf174) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 831

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384354.1 → NP_001371283.1  zinc finger protein 831

    Status: VALIDATED

    Source sequence(s)
    AL121919, AL136532
    Consensus CDS
    CCDS42894.1
    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Related
    ENSP00000490240.1, ENST00000637017.1
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  2. NM_178457.3 → NP_848552.1  zinc finger protein 831

    See identical proteins and their annotated locations for NP_848552.1

    Status: VALIDATED

    Source sequence(s)
    AL121919
    Consensus CDS
    CCDS42894.1
    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Related
    ENSP00000360069.2, ENST00000371030.4
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    59123388..59259113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439881.1 → XP_047295837.1  zinc finger protein 831 isoform X1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0

  2. XM_047439880.1 → XP_047295836.1  zinc finger protein 831 isoform X1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0

  3. XM_011528534.3 → XP_011526836.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_011526836.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006723698.4 → XP_006723761.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_006723761.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011528540.3 → XP_011526842.1  zinc finger protein 831 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011528536.3 → XP_011526838.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_011526838.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  7. XM_047439882.1 → XP_047295838.1  zinc finger protein 831 isoform X1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0

  8. XM_011528537.3 → XP_011526839.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_011526839.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  9. XM_005260273.4 → XP_005260330.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_005260330.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

  10. XM_011528538.3 → XP_011526840.1  zinc finger protein 831 isoform X1

    See identical proteins and their annotated locations for XP_011526840.1

    UniProtKB/Swiss-Prot
    Q5JPB2, Q5TDR4, Q8TCP0
    Conserved Domains (2) summary
    sd00017
    Location:146 → 166
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 183
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    60906490..61042393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322952.1 → XP_054178927.1  zinc finger protein 831 isoform X1

  2. XM_054322953.1 → XP_054178928.1  zinc finger protein 831 isoform X1

  3. XM_054322955.1 → XP_054178930.1  zinc finger protein 831 isoform X1

  4. XM_054322960.1 → XP_054178935.1  zinc finger protein 831 isoform X2

  5. XM_054322954.1 → XP_054178929.1  zinc finger protein 831 isoform X1

  6. XM_054322959.1 → XP_054178934.1  zinc finger protein 831 isoform X1

  7. XM_054322956.1 → XP_054178931.1  zinc finger protein 831 isoform X1

  8. XM_054322958.1 → XP_054178933.1  zinc finger protein 831 isoform X1

  9. XM_054322957.1 → XP_054178932.1  zinc finger protein 831 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JPB2.4 GenPept UniProtKB/Swiss-Prot:Q5JPB2

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