U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127890718 H3K27ac hESC enhancer GRCh37_chr19:16739143-16740074 [ Homo sapiens (human) ]

Gene ID: 127890718, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC127890718
Gene description
H3K27ac hESC enhancer GRCh37_chr19:16739143-16740074
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes two accessible chromatin subregions that were validated as silencers based on their ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127890718 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (16628228..16629263)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16763019..16764054)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16680351-16680851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:16683261-16684135 Neighboring gene uncharacterized LOC105372295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16692801-16693372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16693373-16693944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16695630-16696166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16696804-16697686 Neighboring gene mediator complex subunit 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16702872-16703374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:16716746-16717543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10310 Neighboring gene uncharacterized LOC105372296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16748865-16749364 Neighboring gene small integral membrane protein 7 Neighboring gene uncharacterized LOC124904647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16772303-16773111 Neighboring gene transmembrane protein 38A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:16790368-16790868

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 10311
  • ATAC-STARR-seq lymphoblastoid silent region 10312

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_140630.2 

    Range
    101..1136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    16628228..16629263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    16763019..16764054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases