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LOC127885663 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7476397-7477152 [ Homo sapiens (human) ]

Gene ID: 127885663, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127885663
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7476397-7477152
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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Genomic context

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Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7573079..7573834)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7477326..7478081)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7460817-7461610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11627 Neighboring gene TNF superfamily member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8128 Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7466006-7466702 Neighboring gene SUMO specific peptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7477153-7477908 Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene small nucleolar RNA, H/ACA box 48 Neighboring gene small nucleolar RNA, C/D box 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_135404.1 

    Range
    101..856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7573079..7573834
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7477326..7478081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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