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LOC127460298 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127591655-127592462 [ Homo sapiens (human) ]

Gene ID: 127460298, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127460298
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127591655-127592462
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127460298 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (126579410..126580217)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (127706537..127707344)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375750 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:127534858-127535674 Neighboring gene MPRA-validated peak7170 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:127559131-127559886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:127564099-127564608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27929 Neighboring gene uncharacterized LOC105375751 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127570125-127570961 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127592463-127593270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:127593271-127594077 Neighboring gene zinc finger protein 724-like Neighboring gene LRAT domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 547 Neighboring gene RNA, U11 small nuclear 4, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_115067.1 

    Range
    101..908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    126579410..126580217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    127706537..127707344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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