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LOC127274626 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122091915-122092848 [ Homo sapiens (human) ]

Gene ID: 127274626, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127274626
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122091915-122092848
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127274626 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (121334288..121335272)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (121769574..121770558)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:121974845-121975346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:122003829-122004330 Neighboring gene transcription factor CP2 like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122094177-122094762 Neighboring gene ribosomal protein S17 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122109698-122109870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16463 Neighboring gene cytoplasmic linker associated protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122140378-122140878 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:122187059-122188258 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:122205649-122205872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16465 Neighboring gene CLASP1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:122405992-122406620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:122406621-122407247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16469 Neighboring gene NIFK antisense RNA 1 Neighboring gene ribosomal protein L12 pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 11921

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_096476.2 

    Range
    101..1085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    121334288..121335272
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    121769574..121770558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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