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LOC127270743 OCT4-NANOG hESC enhancer GRCh37_chr1:166097641-166098142 [ Homo sapiens (human) ]

Gene ID: 127270743, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127270743
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr1:166097641-166098142
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (166128404..166128905)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (165474447..165474948)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 64 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:166033205-166033704 Neighboring gene MPRA-validated peak439 silencer Neighboring gene family with sequence similarity 78 member B Neighboring gene FAM78B antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_946 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_966 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:166135105-166136007 Neighboring gene uncharacterized LOC112268276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2025 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1002 Neighboring gene microRNA 921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1510 Neighboring gene EWS RNA binding protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_092595.1 

    Range
    101..602
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    166128404..166128905
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    165474447..165474948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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