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LOC127267706 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17020446-17021273 [ Homo sapiens (human) ]

Gene ID: 127267706, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127267706
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17020446-17021273
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16693951..16694778)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (16409542..16410369)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Gly (CCC) 4-1 Neighboring gene EIF1AX pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17019619-17020445 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:17021274-17022100 Neighboring gene espin pseudogene Neighboring gene uncharacterized LOC124903858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17027493-17028178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17034088-17034627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17034628-17035166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17043745-17044298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17044853-17045406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17045407-17045959 Neighboring gene tRNA-Val (CAC) 13-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_098421.1 

    Range
    101..928
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16693951..16694778
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791756.1 Reference GRCh38.p14 PATCHES

    Range
    558785..559612 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    16409542..16410369
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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