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CNR1 cannabinoid receptor 1 [ Homo sapiens (human) ]

Gene ID: 1268, updated on 3-Apr-2024

Summary

Official Symbol
CNR1provided by HGNC
Official Full Name
cannabinoid receptor 1provided by HGNC
Primary source
HGNC:HGNC:2159
See related
Ensembl:ENSG00000118432 MIM:114610; AllianceGenome:HGNC:2159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Expression
Biased expression in brain (RPKM 6.2), fat (RPKM 2.7) and 12 other tissues See more
Orthologs
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Genomic context

See CNR1 in Genome Data Viewer
Location:
6q15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (88139864..88167349, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (89348358..89375841, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88849583..88877068, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986541 Neighboring gene sperm acrosome associated 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:88834755-88835954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:88893112-88893675 Neighboring gene MPRA-validated peak5945 silencer Neighboring gene ribosomal protein S14 pseudogene 9 Neighboring gene ACTB pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs PubMed
env HIV-1 gp120 downregulates expression of cannabinoid receptor 1 (CB1) in human brain micro vascular endothelial cells (HBMEC) PubMed
Tat tat HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol PubMed
tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cannabinoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
involved_in cannabinoid signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mast cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of serotonin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of acute inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fever generation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde trans-synaptic signaling by endocannabinoid IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cannabinoid receptor 1
Names
cannabinoid receptor 1 (brain)
central cannabinoid receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160226.3NP_001153698.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153698.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001160258.3NP_001153730.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153730.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Related
    ENSP00000446702.2, ENST00000551417.2
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001160259.3NP_001153731.1  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001153731.1

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001365869.2NP_001352798.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Related
    ENSP00000358511.2, ENST00000369499.3
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001365870.2NP_001352799.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_001365872.2NP_001352801.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_001365874.3NP_001352803.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Related
    ENSP00000412192.2, ENST00000428600.3
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  8. NM_001370545.1NP_001357474.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  9. NM_001370546.1NP_001357475.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  10. NM_001370547.1NP_001357476.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  11. NM_001424094.1NP_001411023.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  12. NM_001424095.1NP_001411024.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  13. NM_001424096.1NP_001411025.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  14. NM_001424097.1NP_001411026.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  15. NM_001424098.1NP_001411027.1  cannabinoid receptor 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  16. NM_016083.6NP_057167.2  cannabinoid receptor 1 isoform a

    See identical proteins and their annotated locations for NP_057167.2

    Status: REVIEWED

    Source sequence(s)
    AL121835, AL136096
    Consensus CDS
    CCDS5015.1
    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    Q506J9, S5TLS4
    Related
    ENSP00000358513.2, ENST00000369501.3
    Conserved Domains (1) summary
    cd15340
    Location:117408
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  17. NM_033181.4NP_149421.2  cannabinoid receptor 1 isoform b

    See identical proteins and their annotated locations for NP_149421.2

    Status: REVIEWED

    Source sequence(s)
    AY766182, BM682178, BX538191, DA239984, DA793373, DA799263, X54937, X81120
    Consensus CDS
    CCDS5016.2
    UniProtKB/TrEMBL
    Q506J9, V5KA96
    Related
    ENSP00000420188.1, ENST00000468898.2
    Conserved Domains (1) summary
    cd15340
    Location:84375
    7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    88139864..88167349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418171.1XP_047274127.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  2. XM_047418173.1XP_047274129.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  3. XM_047418172.1XP_047274128.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    89348358..89375841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354204.1XP_054210179.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  2. XM_054354206.1XP_054210181.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4
  3. XM_054354205.1XP_054210180.1  cannabinoid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R9T4, E1P512, P21554, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    UniProtKB/TrEMBL
    S5TLS4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001160260.1: Suppressed sequence

    Description
    NM_001160260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.