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OSCAR osteoclast associated Ig-like receptor [ Homo sapiens (human) ]

Gene ID: 126014, updated on 11-Apr-2024

Summary

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Official Symbol
OSCARprovided by HGNC
Official Full Name
osteoclast associated Ig-like receptorprovided by HGNC
Primary source
HGNC:HGNC:29960
See related
Ensembl:ENSG00000170909 MIM:606862; AllianceGenome:HGNC:29960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIGR3; PIgR-3
Summary
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Expression
Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54094668..54100803, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57173230..57179492, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54597933..54604094, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene V-set and transmembrane domain containing 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54605952-54606928 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54617323-54618196 Neighboring gene TCF3 fusion partner Neighboring gene PRPF31 antisense RNA 1 Neighboring gene pre-mRNA processing factor 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women. Wang D, et al. Clin Exp Pharmacol Physiol, 2020 Aug. PMID 32246488
  2. OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis. Schultz HS, et al. Eur J Immunol, 2016 Apr. PMID 26786702
  3. Structural basis for collagen recognition by the immune receptor OSCAR. Zhou L, et al. Blood, 2016 Feb 4. PMID 26552697, Free PMC Article
  4. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. Barrow AD, et al. J Immunol, 2015 Apr 1. PMID 25716998, Free PMC Article
  5. Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk. Ndongo-Thiam N, et al. Ann Rheum Dis, 2014 Jun. PMID 24448348

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.
    Title: Sex-biased ceRNA networks reveal that OSCAR can promote proliferation and migration of lung adenocarcinoma in women.
  2. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
    Title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
  3. regulation of OSCAR by TNF-alpha and receptor activator of NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts
    Title: Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial Tissues of Patients with Active RA and TNF-α and RANKL Regulation of Expression by Osteoclasts In Vitro.
  4. OSCAR can play a proinflammatory role in monocyte-derived cells and may contribute crucially on multiple levels to rheumatoid arthritis pathogenesis.
    Title: OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis.
  5. Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI and LAIR-1.
    Title: Structural basis for collagen recognition by the immune receptor OSCAR.
  6. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.
    Title: OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.
  7. Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.
    Title: The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints.
  8. Plasma OSCAR level was higher in the serum of RA patients than controls, and higher in patients with destructive RA rather than non-destructive RA.
    Title: Levels of soluble osteoclast-associated receptor (sOSCAR) in rheumatoid arthritis: link to disease severity and cardiovascular risk.
  9. Rotative stress in mouse cells results in increased levels of Oscar transcription.
    Title: The effect of rotative stress on CAII, FAS, FASL, OSCAR, and TRAP gene expression in osteoclasts.
  10. endothelial cell-derived OSCAR was found to be involved in the STAT signaling pathway and to affect monocyte adhesion.
    Title: Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33613

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables collagen receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in specific granule lumen TAS
Traceable Author Statement
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
osteoclast-associated immunoglobulin-like receptor
Names
osteoclast associated receptor OSCAR-S1
osteoclast associated receptor OSCAR-S2
osteoclast associated, immunoglobulin-like receptor
poly-Ig receptor 3
polymeric immunoglobulin receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282349.3 → NP_001269278.1  osteoclast-associated immunoglobulin-like receptor isoform 6 precursor

    See identical proteins and their annotated locations for NP_001269278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS74444.1
    UniProtKB/Swiss-Prot
    B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
    Related
    ENSP00000365808.2, ENST00000284648.10
    Conserved Domains (2) summary
    smart00410
    Location:38 → 100
    IG_like; Immunoglobulin like
    cl11960
    Location:31 → 124
    Ig; Immunoglobulin domain

  2. NM_001282350.3 → NP_001269279.1  osteoclast-associated immunoglobulin-like receptor isoform 7 precursor

    See identical proteins and their annotated locations for NP_001269279.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS62789.1
    UniProtKB/Swiss-Prot
    B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
    Related
    ENSP00000375641.1, ENST00000391761.5
    Conserved Domains (2) summary
    smart00410
    Location:27 → 89
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 113
    Ig; Immunoglobulin domain

  3. NM_130771.6 → NP_570127.3  osteoclast-associated immunoglobulin-like receptor isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS12873.1
    UniProtKB/TrEMBL
    A0A087X1R2, A0A0G2JMM7
    Related
    ENSP00000348927.3, ENST00000356532.7
    Conserved Domains (2) summary
    smart00410
    Location:42 → 104
    IG_like; Immunoglobulin like
    cl11960
    Location:35 → 128
    Ig; Immunoglobulin domain

  4. NM_133168.6 → NP_573398.2  osteoclast-associated immunoglobulin-like receptor isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS12874.1
    UniProtKB/TrEMBL
    A0A0A0MR14, A0A0G2JMM7
    Related
    ENSP00000304523.5, ENST00000351806.8
    Conserved Domains (2) summary
    smart00410
    Location:27 → 89
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 113
    Ig; Immunoglobulin domain

  5. NM_133169.6 → NP_573399.2  osteoclast-associated immunoglobulin-like receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_573399.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region and lacks an internal segment in its 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS12875.1
    UniProtKB/TrEMBL
    A0A0A0MRF2, A0A0G2JMM7
    Related
    ENSP00000351145.4, ENST00000358375.9
    Conserved Domains (2) summary
    smart00410
    Location:38 → 100
    IG_like; Immunoglobulin like
    cl11960
    Location:31 → 124
    Ig; Immunoglobulin domain

  6. NM_206818.4 → NP_996554.2  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS12876.1
    UniProtKB/Swiss-Prot
    B7WNS2, Q5GRG5, Q8IYS5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
    UniProtKB/TrEMBL
    A0A087WV17
    Related
    ENSP00000352671.4, ENST00000359649.8
    Conserved Domains (2) summary
    smart00410
    Location:42 → 104
    IG_like; Immunoglobulin like
    cl11960
    Location:35 → 128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54094668..54100803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    69046..75207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57173230..57179492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_206817.1: Suppressed sequence

    Description
    NM_206817.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IYS5.3 GenPept UniProtKB/Swiss-Prot:Q8IYS5

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