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SLC38A10 solute carrier family 38 member 10 [ Homo sapiens (human) ]

Gene ID: 124565, updated on 11-Apr-2024

Summary

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Official Symbol
SLC38A10provided by HGNC
Official Full Name
solute carrier family 38 member 10provided by HGNC
Primary source
HGNC:HGNC:28237
See related
Ensembl:ENSG00000157637 MIM:616525; AllianceGenome:HGNC:28237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP1744; SNAT10
Summary
Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within bone development. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 17.0), placenta (RPKM 15.5) and 25 other tissues See more
Orthologs
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Genomic context

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See SLC38A10 in Genome Data Viewer
Location:
17q25.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81244811..81295307, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82153934..82207205, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79218611..79269107, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904081 Neighboring gene TEPSIN adaptor related protein complex 4 accessory protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79212179-79212761 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79212737-79212952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12956 Neighboring gene Sharpr-MPRA regulatory region 11657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12957 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79225481-79226148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79228507-79229198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79255689-79256202 Neighboring gene Sharpr-MPRA regulatory region 13761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12961 Neighboring gene uncharacterized LOC124904082 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79273333-79273505 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5937 Neighboring gene long intergenic non-protein coding RNA 482

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease. Hashimoto M, et al. J Alzheimers Dis, 2019. PMID 31524172
  2. The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. Hellsten SV, et al. FEBS Open Bio, 2017 Jun. PMID 28593130, Free PMC Article
  3. The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. Sundberg BE, et al. J Mol Neurosci, 2008 Jun. PMID 18418736
  4. Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Schiöth HB, et al. Mol Aspects Med, 2013 Apr-Jun. PMID 23506890
  5. Joint influence of small-effect genetic variants on human longevity. Yashin AI, et al. Aging (Albany NY), 2010 Sep. PMID 20834067, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.
    Title: A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Joint influence of small-effect genetic variants on human longevity.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35718, FLJ46399, MGC15523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 38 member 10; putative sodium-coupled neutral amino acid transporter 10
Names
Sodium-coupled neutral amino acid transporter 10
amino acid transporter SLC38A10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037984.3 → NP_001033073.1  solute carrier family 38 member 10 isoform a

    See identical proteins and their annotated locations for NP_001033073.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK128330, BC014642, BI194553, BM129331, BQ642219, BU552914, CA447446, HY036951
    Consensus CDS
    CCDS42397.1
    UniProtKB/Swiss-Prot
    Q6ZRC5, Q8NA99, Q96C66, Q9HBR0
    Related
    ENSP00000363891.3, ENST00000374759.8
    Conserved Domains (4) summary
    PHA00666
    Location:582 → 739
    PHA00666; putative protease
    COG0814
    Location:14 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481 → 683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_138570.4 → NP_612637.1  solute carrier family 38 member 10 isoform b

    See identical proteins and their annotated locations for NP_612637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC014642, BQ642219, CA416101, HY036951
    Consensus CDS
    CCDS11780.1
    UniProtKB/Swiss-Prot
    Q9HBR0
    Related
    ENSP00000288439.5, ENST00000288439.9
    Conserved Domains (3) summary
    COG0814
    Location:14 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481 → 683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81244811..81295307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257019.2 → XP_005257076.1  putative sodium-coupled neutral amino acid transporter 10 isoform X2

    Conserved Domains (3) summary
    COG0814
    Location:14 → 397
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:481 → 683
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6 → 381
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_011524289.2 → XP_011522591.1  putative sodium-coupled neutral amino acid transporter 10 isoform X3

    Conserved Domains (4) summary
    PHA00666
    Location:589 → 746
    PHA00666; putative protease
    COG0814
    Location:14 → 404
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:488 → 690
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6 → 388
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_011524288.2 → XP_011522590.1  putative sodium-coupled neutral amino acid transporter 10 isoform X1

    Conserved Domains (3) summary
    COG0814
    Location:14 → 404
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    pfam05466
    Location:488 → 690
    BASP1; Brain acid soluble protein 1 (BASP1 protein)
    cl00456
    Location:6 → 388
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. XM_011524290.2 → XP_011522592.1  putative sodium-coupled neutral amino acid transporter 10 isoform X4

    Conserved Domains (2) summary
    PRK07764
    Location:449 → 886
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl00456
    Location:2 → 299
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82153934..82207205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314988.1 → XP_054170963.1  putative sodium-coupled neutral amino acid transporter 10 isoform X2

  2. XM_054314989.1 → XP_054170964.1  putative sodium-coupled neutral amino acid transporter 10 isoform X3

  3. XM_054314987.1 → XP_054170962.1  putative sodium-coupled neutral amino acid transporter 10 isoform X1

  4. XM_054314990.1 → XP_054170965.1  putative sodium-coupled neutral amino acid transporter 10 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HBR0.2 GenPept UniProtKB/Swiss-Prot:Q9HBR0

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