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CLPS colipase [ Homo sapiens (human) ]

Gene ID: 1208, updated on 5-Mar-2024

Summary

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Official Symbol
CLPSprovided by HGNC
Official Full Name
colipaseprovided by HGNC
Primary source
HGNC:HGNC:2085
See related
Ensembl:ENSG00000137392 MIM:120105; AllianceGenome:HGNC:2085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Restricted expression toward pancreas (RPKM 17741.6) See more
Orthologs
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Genomic context

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Location:
6p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35794982..35797323, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35615336..35617677, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35762759..35765100, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35749907-35750408 Neighboring gene colipase like 2 Neighboring gene colipase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17101 Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:35810876-35811031 Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC124901311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. Xiao X, et al. J Lipid Res, 2013 Feb. PMID 23204298, Free PMC Article
  2. Procolipase gene: no association with early-onset obesity or fat intake. Wermter AK, et al. Obes Facts, 2009. PMID 20054203, Free PMC Article
  3. Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians. Weyrich P, et al. Exp Clin Endocrinol Diabetes, 2009 Feb. PMID 18726866
  4. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. D'Silva S, et al. J Lipid Res, 2007 Nov. PMID 17715423, Free PMC Article
  5. Regulation of lipases by lipid-lipid interactions: implications for lipid-mediated signaling in cells. Sugar IP, et al. Chem Phys Lipids, 2003 Jan. PMID 12598038

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low CLPS expression is associated with pancreatic cancer.
    Title: Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer.
  2. humans with the Arg92Cys substitution will secrete less functional colipase
    Title: The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.
  3. found no evidence for an association of pancreatic colipase(CLPS) single nucleotide polymorphisms rs2766597, rs41270082, rs3748050, and rs3748051 with obesity or percentage of dietary fat intake
    Title: Procolipase gene: no association with early-onset obesity or fat intake.
  4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Procolipase gene: no association with early-onset obesity or fat intake.
  5. CLPS genetic variability associates with insulin secretory function in non-diabetic humans and may represent a novel candidate gene for development of type 2 diabetes
    Title: Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variability of procolipase associates with altered insulin secretion in non-diabetic Caucasians.
  7. Our findings demonstrate that the Arg92Cys polymorphism decreases the function of Cys92 colipase. This change may contribute to the development of type 2 diabetes.
    Title: A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides.
  8. evidence in two German Caucasian study populations that the variant of the rare colipase Arg109Cys polymorphism might contribute to increased susceptibility of type 2 diabetes
    Title: Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates pancreatic colipase in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in response to food IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
colipase
Names
colipase, pancreatic
pancreatic colipase preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252597.2 → NP_001239526.1  colipase isoform 2

    See identical proteins and their annotated locations for NP_001239526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. Translation of variant 2 begins in the alternate exon, and the resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BI439786, BP322637, BP324927, BQ271978
    Consensus CDS
    CCDS75437.1
    UniProtKB/TrEMBL
    A0A087WZW1
    Related
    ENSP00000482919.1, ENST00000622413.2
    Conserved Domains (1) summary
    smart00023
    Location:15 → 98
    COLIPASE; Colipase

  2. NM_001252598.2 → NP_001239527.1  colipase isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001239527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BP321569, BP324927
    Consensus CDS
    CCDS75438.1
    UniProtKB/TrEMBL
    A0A087X0Q7, Q5U808
    Related
    ENSP00000483589.1, ENST00000616014.3
    Conserved Domains (1) summary
    smart00023
    Location:18 → 71
    COLIPASE; Colipase

  3. NM_001832.4 → NP_001823.1  colipase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BP324927
    Consensus CDS
    CCDS4811.1
    UniProtKB/Swiss-Prot
    P04118, Q5T9G7, Q5U809
    Related
    ENSP00000259938.2, ENST00000259938.7
    Conserved Domains (1) summary
    smart00023
    Location:18 → 112
    COLIPASE; Colipase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    35794982..35797323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    35615336..35617677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04118.2 GenPept UniProtKB/Swiss-Prot:P04118

Gene LinkOut

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