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SLC16A10 solute carrier family 16 member 10 [ Homo sapiens (human) ]

Gene ID: 117247, updated on 3-Apr-2024

Summary

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Official Symbol
SLC16A10provided by HGNC
Official Full Name
solute carrier family 16 member 10provided by HGNC
Primary source
HGNC:HGNC:17027
See related
Ensembl:ENSG00000112394 MIM:607550; AllianceGenome:HGNC:17027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAT1; MCT10; PRO0813
Summary
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
Expression
Broad expression in placenta (RPKM 4.2), skin (RPKM 2.5) and 19 other tissues See more
Orthologs
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Genomic context

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See SLC16A10 in Genome Data Viewer
Location:
6q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (111087503..111231194)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112266105..112414313)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111408706..111552397)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901375 Neighboring gene ribosome production factor 2 homolog Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:111337799-111338443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17472 Neighboring gene glutathione S-transferase mu 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17473 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111409089-111409589 Neighboring gene RNA, U6 small nuclear 960, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:111428108-111429307 Neighboring gene small nucleolar RNA, C/D box 166 Neighboring gene uncharacterized LOC124901377 Neighboring gene MFSD4B divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr6:111573581-111573781 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575060-111575706 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111575707-111576354 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111576355-111577001 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:111577002-111577648 Neighboring gene uncharacterized LOC124901378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24942 Neighboring gene Sharpr-MPRA regulatory region 12211 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_87657 Neighboring gene major facilitator superfamily domain containing 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae. Uemura S, et al. Biochim Biophys Acta Biomembr, 2017 Oct. PMID 28754537
  2. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Kim DK, et al. Genomics, 2002 Jan. PMID 11827462
  3. ΔNp63 transcript loss in bladder cancer constitutes an independent molecular predictor of TaT1 patients post-treatment relapse and progression. Papadimitriou MA, et al. J Cancer Res Clin Oncol, 2019 Dec. PMID 31595333
  4. Effects of thyroid hormone transporters MCT8 and MCT10 on nuclear activity of T3. van Mullem AA, et al. Mol Cell Endocrinol, 2016 Dec 5. PMID 27492966
  5. Monitoring the treatment outcome in endometrial cancer patients by CEA and TATI. Kozakiewicz B, et al. Tumour Biol, 2016 Jul. PMID 26779635, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank.
    Title: Association of DIO2 and MCT10 Polymorphisms With Persistent Symptoms in LT4-Treated Patients in the UK Biobank.
  2. Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
    Title: Single Nucleotide Polymorphisms in Thyroid Hormone Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to Inter-Individual Variance of Executive Functions and Personality Traits.
  3. Molecular predictor of TaT1 patients.
    Title: ΔNp63 transcript loss in bladder cancer constitutes an independent molecular predictor of TaT1 patients post-treatment relapse and progression.
  4. In the MCT10 modeled structure, N81 appeared to protrude into the putative trajectory of tryptophan.
    Title: Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae.
  5. the aim of this study was to examine if MCT8 and MCT10 increase the availability of triiodothyronine for its nuclear receptor.
    Title: Effects of thyroid hormone transporters MCT8 and MCT10 on nuclear activity of T3.
  6. High TAT1 expression is associated with metastasis and recurrence in endometrial cancer.
    Title: Monitoring the treatment outcome in endometrial cancer patients by CEA and TATI.
  7. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
    Title: The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.
  8. monocarboxylate transporter 10 facilitates bromoacetyl [(125)I] iodothyronine transport, but is not labeled by it
    Title: The thyroid hormone transporters MCT8 and MCT10 transport the affinity-label N-bromoacetyl-[(125)I]T3 but are not modified by it.
  9. The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis.
    Title: Expression of thyroid hormone transporters in the human hypothalamus.
  10. Increased MCT8 and decreased MCT10 expression within placentae of pregnancies complicated by IUGR may contribute to aberrant development of the fetoplacental unit.
    Title: Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of solute carrier family 16 (aromatic amino acid transporter), member 10 (SLC16A10) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-phenylalanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-tryptophan transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-tyrosine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables aromatic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thyroid hormone transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport TAS
Traceable Author Statement
more info
  
involved_in aromatic amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aromatic amino acid transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thyroid-stimulating hormone secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in basolateral plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 10
Names
MCT 10
T-type amino acid transporter 1
aromatic amino acid transporter 1
solute carrier family 16 (aromatic amino acid transporter), member 10
solute carrier family 16 (monocarboxylic acid transporters), member 10
solute carrier family 16, member 10 (aromatic amino acid transporter)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018593.5 → NP_061063.2  monocarboxylate transporter 10

    See identical proteins and their annotated locations for NP_061063.2

    Status: VALIDATED

    Source sequence(s)
    AB057445, AL360227, BC017968
    Consensus CDS
    CCDS5089.1
    UniProtKB/Swiss-Prot
    B3KWY0, Q6ZMG0, Q8TF71, Q8WVI5
    Related
    ENSP00000357844.4, ENST00000368851.10
    Conserved Domains (2) summary
    cd06174
    Location:71 → 470
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:67 → 487
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    111087503..111231194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418167.1 → XP_047274123.1  monocarboxylate transporter 10 isoform X2

  2. XM_011535422.3 → XP_011533724.1  monocarboxylate transporter 10 isoform X2

    See identical proteins and their annotated locations for XP_011533724.1

    UniProtKB/TrEMBL
    Q05BR4
    Conserved Domains (1) summary
    cd06174
    Location:71 → 254
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  3. XM_006715329.3 → XP_006715392.1  monocarboxylate transporter 10 isoform X1

    See identical proteins and their annotated locations for XP_006715392.1

    UniProtKB/TrEMBL
    Q05BR4
    Conserved Domains (1) summary
    cl28910
    Location:70 → 316
    MFS; Major Facilitator Superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    112266105..112414313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354195.1 → XP_054210170.1  monocarboxylate transporter 10 isoform X2

  2. XM_054354196.1 → XP_054210171.1  monocarboxylate transporter 10 isoform X2

  3. XM_054354194.1 → XP_054210169.1  monocarboxylate transporter 10 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TF71.1 GenPept UniProtKB/Swiss-Prot:Q8TF71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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