U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MRGPRX2 MAS related GPR family member X2 [ Homo sapiens (human) ]

Gene ID: 117194, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
MRGPRX2provided by HGNC
Official Full Name
MAS related GPR family member X2provided by HGNC
Primary source
HGNC:HGNC:17983
See related
Ensembl:ENSG00000183695 MIM:607228; AllianceGenome:HGNC:17983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGRG3; MRGX2
Summary
Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11p15.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19054455..19060717, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19174588..19180847, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19076002..19082264, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X10, pseudogene Neighboring gene MAS related GPR family member X9, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3197 Neighboring gene zinc finger DHHC-type palmitoyltransferase 13 Neighboring gene VISTA enhancer hs2144 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene cysteine and glycine rich protein 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2. Raj S, et al. Front Immunol, 2023. PMID 37228611, Free PMC Article
  2. Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies. Toscano A, et al. Front Immunol, 2022. PMID 36726977, Free PMC Article
  3. The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation. Hsin L, et al. Pharmacol Res Perspect, 2022 Aug. PMID 35904495, Free PMC Article
  4. Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity. Chompunud Na Ayudhya C, et al. Immunol Allergy Clin North Am, 2022 May. PMID 35469618, Free PMC Article
  5. MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G(αi), G(αq), Ca++ Channels, ERK1/2 and PI3K-Interconnection between Early and Late Signaling. Wang Z, et al. Cells, 2022 Mar 10. PMID 35326404, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Beyond Allergies-Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis.
    Title: Beyond Allergies-Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis.
  2. Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
    Title: Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2.
  3. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
  4. PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
    Title: PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain.
  5. Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2.
    Title: Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2.
  6. Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies.
    Title: Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies.
  7. Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
    Title: Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
  8. The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation.
    Title: The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation.
  9. Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo.
    Title: Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo.
  10. Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity.
    Title: Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mast cell secretagogue receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mast cell degranulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of pain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sleep NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mas-related G-protein coupled receptor member X2
Names
G protein-coupled receptor MRGX2
MAS-related GPR, member X2
Mas-related G protein-coupled receptor G3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303615.2 → NP_001290544.1  mas-related G-protein coupled receptor member X2

    See identical proteins and their annotated locations for NP_001290544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027026, BC063450, HY005030
    Consensus CDS
    CCDS7847.1
    UniProtKB/Swiss-Prot
    B5B0C7, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, Q96LB1, W8W3L5
    Conserved Domains (1) summary
    cd15106
    Location:31 → 308
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_054030.4 → NP_473371.1  mas-related G-protein coupled receptor member X2

    See identical proteins and their annotated locations for NP_473371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027026, BC063450
    Consensus CDS
    CCDS7847.1
    UniProtKB/Swiss-Prot
    B5B0C7, Q4QXW4, Q4QXW7, Q4QXX0, Q4QXX2, Q4QXX3, Q4QXX4, Q4QXX6, Q4QXX7, Q96LB1, W8W3L5
    Related
    ENSP00000333800.2, ENST00000329773.3
    Conserved Domains (1) summary
    cd15106
    Location:31 → 308
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    19054455..19060717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    19174588..19180847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LB1.1 GenPept UniProtKB/Swiss-Prot:Q96LB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous