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CKS1B CDC28 protein kinase regulatory subunit 1B [ Homo sapiens (human) ]

Gene ID: 1163, updated on 5-Mar-2024

Summary

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Official Symbol
CKS1Bprovided by HGNC
Official Full Name
CDC28 protein kinase regulatory subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:19083
See related
Ensembl:ENSG00000173207 MIM:116900; AllianceGenome:HGNC:19083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKS1; ckshs1; PNAS-16; PNAS-18
Summary
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154974681..154979251)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154114042..154118612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154947157..154951727)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154931761-154932260 Neighboring gene pygopus family PHD finger 2 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:154933865-154934605 and GRCh37_chr1:154934606-154935345 Neighboring gene PYGO2 and SHC1 antisense RNA 1 Neighboring gene SHC adaptor protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942000-154942550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154942551-154943101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1800 Neighboring gene microRNA 4258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154953875-154954472 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154955073-154955670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154958088-154958777 Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors. Jia Y, et al. Biomed Res Int, 2021. PMID 34845438, Free PMC Article
  2. The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. Hao S, et al. Mod Pathol, 2021 Feb. PMID 32908255
  3. Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway. Zeng Z, et al. Int J Mol Med, 2019 Jul. PMID 31115482, Free PMC Article
  4. Prognostic and clinicopathological significance of Cks1 in cancer: Evidence from a meta-analysis. Zhang Y, et al. J Cell Physiol, 2019 Aug. PMID 30605238
  5. Cks1 regulates human hepatocellular carcinoma cell progression through osteopontin expression. Kang YS, et al. Biochem Biophys Res Commun, 2019 Jan 1. PMID 30497779

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.
    Title: Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.
  2. Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1.
    Title: Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1.
  3. A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors.
    Title: A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors.
  4. CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
    Title: CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
  5. The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
    Title: The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
  6. Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA4855p/CKS1B axis.
    Title: Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA‑485‑5p/CKS1B axis.
  7. High Cks1 expression predicted poorer prognosis and worse clinicopathological parameters in various cancers. Increased Cks1 could be a significant prognostic biomarker for poor survival in patients with various cancers. Meta-analysis.
    Title: Prognostic and clinicopathological significance of Cks1 in cancer: Evidence from a meta-analysis.
  8. Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC.
    Title: MicroRNA-1258 Inhibits the Proliferation and Migration of Human Colorectal Cancer Cells through Suppressing CKS1B Expression.
  9. The key observations of the present study demonstrated that shCKS1B can inhibit the proliferation, invasion and angiogenesis of Retinoblastoma cells by suppressing the MEK/ERK signaling pathway.
    Title: Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway.
  10. the data propose a novel function for Cks1 as a tumor promoter through the expression of the strongly oncogenic protein osteopontin (OPN) in human hepatocellular carcinoma (HCC).
    Title: Cks1 regulates human hepatocellular carcinoma cell progression through osteopontin expression.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cyclin-dependent kinases regulatory subunit 1
Names
CDC2-associated protein CKS1
CDC28 protein kinase 1B
NB4 apoptosis/differentiation related protein
cell division control protein CKS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001826.3 → NP_001817.1  cyclin-dependent kinases regulatory subunit 1

    See identical proteins and their annotated locations for NP_001817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AL451085, BQ883992, CN347951
    Consensus CDS
    CCDS1077.1
    UniProtKB/Swiss-Prot
    P33551, P61024
    UniProtKB/TrEMBL
    Q5T178
    Related
    ENSP00000311083.5, ENST00000308987.6
    Conserved Domains (1) summary
    pfam01111
    Location:8 → 73
    CKS; Cyclin-dependent kinase regulatory subunit

RNA

  1. NR_024163.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site at the 3' end of the first exon compared to variant 1. There is no evidence that this variant encodes a protein.
    Source sequence(s)
    AL451085, BQ883992, CB161621, CN347951
    Related
    ENST00000368439.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    154974681..154979251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154114042..154118612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61024.1 GenPept UniProtKB/Swiss-Prot:P61024

Gene LinkOut

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