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RNF166 ring finger protein 166 [ Homo sapiens (human) ]

Gene ID: 115992, updated on 7-Apr-2024

Summary

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Official Symbol
RNF166provided by HGNC
Official Full Name
ring finger protein 166provided by HGNC
Primary source
HGNC:HGNC:28856
See related
Ensembl:ENSG00000158717 MIM:617178; AllianceGenome:HGNC:28856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 9.1) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
16q24.2-q24.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88696501..88706408, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94765637..94775565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88762909..88772816, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88717589-88718483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7866 Neighboring gene mevalonate diphosphate decarboxylase Neighboring gene SNAI3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88743941-88744698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88744699-88745454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88747432-88748253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7867 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7868 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:88756108-88756282 Neighboring gene snail family transcriptional repressor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88772291-88772928 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene microRNA 4722 Neighboring gene piezo type mechanosensitive ion channel component 1 (Er blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy. Heath RJ, et al. Cell Rep, 2016 Nov 22. PMID 27880896, Free PMC Article
  2. Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal. Hongbo M, et al. Biochem Biophys Res Commun, 2021 Mar 19. PMID 33545631
  3. RING-finger protein 166 plays a novel pro-apoptotic role in neurotoxin-induced neurodegeneration via ubiquitination of XIAP. Oh CK, et al. Cell Death Dis, 2020 Oct 31. PMID 33130818, Free PMC Article
  4. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Chaste P, et al. Biol Psychiatry, 2015 May 1. PMID 25534755, Free PMC Article
  5. Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6. Chen HW, et al. Sci Rep, 2015 Oct 12. PMID 26456228, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins.
    Title: RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins.
  2. RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.
    Title: RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.
  3. Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal.
    Title: Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal.
  4. An unbiased informatics approach pinpointed RNF166 as a key gene that interacts with the autophagy network and controls the recruitment of ubiquitin as well as the autophagy adaptors p62 and NDP52 to bacteria.
    Title: RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
  5. These findings suggest that RNF166 positively regulates RNA virus-triggered IFN-beta production by enhancing the ubiquitination of TRAF3 and TRAF6.
    Title: Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2647, MGC14381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF166
Names
RING-type E3 ubiquitin transferase RNF166
NP_001165286.1
NP_001165287.1
NP_849163.1
XP_011521147.1
XP_011521149.1
XP_016878401.1
XP_047289533.1
XP_047289534.1
XP_047289535.1
XP_047289536.1
XP_054235492.1
XP_054235493.1
XP_054235494.1
XP_054235495.1
XP_054235496.1
XP_054235497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171815.2 → NP_001165286.1  E3 ubiquitin-protein ligase RNF166 isoform 2

    See identical proteins and their annotated locations for NP_001165286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS54057.1
    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000457336.1, ENST00000567844.1
    Conserved Domains (1) summary
    pfam05605
    Location:68 → 127
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  2. NM_001171816.2 → NP_001165287.1  E3 ubiquitin-protein ligase RNF166 isoform 3

    See identical proteins and their annotated locations for NP_001165287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS54056.1
    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000440454.2, ENST00000541206.6
    Conserved Domains (1) summary
    pfam05605
    Location:40 → 99
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  3. NM_178841.4 → NP_849163.1  E3 ubiquitin-protein ligase RNF166 isoform 1

    See identical proteins and their annotated locations for NP_849163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS10969.1
    UniProtKB/Swiss-Prot
    B3KQ03, D3DX75, H3BTU8, Q96A37, Q96DM0
    UniProtKB/TrEMBL
    A8K4F5
    Related
    ENSP00000326095.4, ENST00000312838.9
    Conserved Domains (3) summary
    cd16549
    Location:30 → 76
    RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
    pfam05605
    Location:149 → 208
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:92 → 124
    zf_C2HC_14; C2HC Zing finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    88696501..88706408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433578.1 → XP_047289534.1  E3 ubiquitin-protein ligase RNF166 isoform X3

  2. XM_011522845.3 → XP_011521147.1  E3 ubiquitin-protein ligase RNF166 isoform X1

    Conserved Domains (2) summary
    TIGR01628
    Location:178 → 304
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd16549
    Location:30 → 76
    RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins

  3. XM_047433580.1 → XP_047289536.1  E3 ubiquitin-protein ligase RNF166 isoform X6

    Related
    ENSP00000446301.2, ENST00000537718.6

  4. XM_047433577.1 → XP_047289533.1  E3 ubiquitin-protein ligase RNF166 isoform X2

  5. XM_011522847.2 → XP_011521149.1  E3 ubiquitin-protein ligase RNF166 isoform X5

    Conserved Domains (1) summary
    pfam05605
    Location:40 → 99
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  6. XM_047433579.1 → XP_047289535.1  E3 ubiquitin-protein ligase RNF166 isoform X5

  7. XM_017022912.2 → XP_016878401.1  E3 ubiquitin-protein ligase RNF166 isoform X4

    Conserved Domains (2) summary
    PLN03208
    Location:24 → 131
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd16549
    Location:30 → 76
    RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    94765637..94775565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379519.1 → XP_054235494.1  E3 ubiquitin-protein ligase RNF166 isoform X3

  2. XM_054379517.1 → XP_054235492.1  E3 ubiquitin-protein ligase RNF166 isoform X1

  3. XM_054379522.1 → XP_054235497.1  E3 ubiquitin-protein ligase RNF166 isoform X6

  4. XM_054379518.1 → XP_054235493.1  E3 ubiquitin-protein ligase RNF166 isoform X2

  5. XM_054379521.1 → XP_054235496.1  E3 ubiquitin-protein ligase RNF166 isoform X5

  6. XM_054379520.1 → XP_054235495.1  E3 ubiquitin-protein ligase RNF166 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A37.1 GenPept UniProtKB/Swiss-Prot:Q96A37

Gene LinkOut

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