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LMTK3 lemur tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 114783, updated on 5-Mar-2024

Summary

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Official Symbol
LMTK3provided by HGNC
Official Full Name
lemur tyrosine kinase 3provided by HGNC
Primary source
HGNC:HGNC:19295
See related
Ensembl:ENSG00000142235 MIM:619624; AllianceGenome:HGNC:19295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMR3; TYKLM3; PPP1R101
Summary
Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in Golgi membrane; axon; and dendrite. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 7.4), duodenum (RPKM 0.9) and 5 other tissues See more
Orthologs
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Genomic context

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See LMTK3 in Genome Data Viewer
Location:
19q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48485271..48513680, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51479429..51507322, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48988528..49016419, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48964846-48965804 Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene uncharacterized LOC105372430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48971727-48972227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48972285-48973278 Neighboring gene potassium inwardly rectifying channel subfamily J member 14 Neighboring gene MPRA-validated peak3539 silencer Neighboring gene cytohesin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48993225-48993796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10884 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48996420-48996611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48997173-48997673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10888 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49017633-49017779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49046825-49047364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49048751-49049694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49054849-49055373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49057162-49058100 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14898 Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway. Wang C, et al. Bioengineered, 2021 Dec. PMID 34516351, Free PMC Article
  2. LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway. Jiang T, et al. FEBS Open Bio, 2020 Oct. PMID 32865871, Free PMC Article
  3. LMTK3 confers chemo-resistance in breast cancer. Stebbing J, et al. Oncogene, 2018 Jun. PMID 29540829, Free PMC Article
  4. Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways. Sun P, et al. Cell Physiol Biochem, 2017. PMID 28848113
  5. LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer. Lu L, et al. Mol Med Rep, 2017 Apr. PMID 28260052, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.
    Title: Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway.
  2. LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.
    Title: LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway.
  3. Our findings support a model in which the MIR2052HG regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via the PKC/MEK/ERK/RSK1 axis. These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer.
    Title: The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1.
  4. targeting of LMTK3 with siRNA delayed KIT-dependent GIST growth in a xenograft model. Our data suggest the potential of LMTK3 as a target for treatment of patients with KIT-mutant cancer, particularly after failure of KIT TKIs.
    Title: LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma.
  5. LMTK3 expression and its role in the drug resistance in breast cancer.
    Title: LMTK3 confers chemo-resistance in breast cancer.
  6. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart.
    Title: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
  7. LMTK-3 increased phosphorylated p38 and JNK, but decreased phosphorylated ERK1/2 and AKT. Overexpression of LMTKs may contribute to biologic behavior changes of PCa, especially cell apoptosis.
    Title: Lemur Tyrosine Kinase-3 Suppresses Growth of Prostate Cancer Via the AKT and MAPK Signaling Pathways.
  8. The serum LMTK3 level was significantly increased in 102 thyroid carcinoma patients compared with 52 benign thyroid tumor patients and 50 healthy volunteers (P=0.001). The protein and mRNA expression of LMTK3 was markedly higher in thyroid cancer patients compared with patients with benign thyroid tumors. LMTK3 knockdown retarded proliferation, invasion and migration in SW579 cells.
    Title: LMTK3 knockdown retards cell growth and invasion and promotes apoptosis in thyroid cancer.
  9. LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
    Title: LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
  10. LMTK3 functions at distal regions in tethering the chromatin to the nuclear periphery, resulting in H3K9me3 modification and gene silencing.
    Title: LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-07-25)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2018-07-25)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1883

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase LMTK3
Names
protein phosphatase 1, regulatory subunit 101
NP_001073903.2
NP_001375414.1
XP_011524713.1
XP_011524714.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080434.2 → NP_001073903.2  serine/threonine-protein kinase LMTK3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008403
    Consensus CDS
    CCDS46136.2
    UniProtKB/Swiss-Prot
    Q4G0U1, Q96Q04
    UniProtKB/TrEMBL
    A0A5F9ZH67
    Related
    ENSP00000500153.1, ENST00000673139.1
    Conserved Domains (2) summary
    PRK07764
    Location:1021 → 1205
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14206
    Location:135 → 410
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

  2. NM_001388485.1 → NP_001375414.1  serine/threonine-protein kinase LMTK3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC008403
    Consensus CDS
    CCDS46136.2
    UniProtKB/Swiss-Prot
    Q4G0U1, Q96Q04
    UniProtKB/TrEMBL
    A0A5F9ZH67
    Related
    ENSP00000472020.1, ENST00000600059.6
    Conserved Domains (2) summary
    PRK07764
    Location:1021 → 1205
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd14206
    Location:135 → 410
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48485271..48513680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526412.3 → XP_011524714.1  serine/threonine-protein kinase LMTK3 isoform X2

    UniProtKB/TrEMBL
    A0A5F9ZH67
    Conserved Domains (2) summary
    smart00221
    Location:148 → 423
    STYKc; Protein kinase; unclassified specificity
    cd14206
    Location:150 → 425
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

  2. XM_011526411.3 → XP_011524713.1  serine/threonine-protein kinase LMTK3 isoform X1

    UniProtKB/TrEMBL
    A0A3B3ISL5, A0A5F9ZH67
    Related
    ENSP00000497480.1, ENST00000650440.1
    Conserved Domains (2) summary
    smart00221
    Location:159 → 434
    STYKc; Protein kinase; unclassified specificity
    cd14206
    Location:161 → 436
    PTKc_Aatyk3; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51479429..51507322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96Q04.2 GenPept UniProtKB/Swiss-Prot:Q96Q04

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