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TRIM9 tripartite motif containing 9 [ Homo sapiens (human) ]

Gene ID: 114088, updated on 5-Mar-2024

Summary

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Official Symbol
TRIM9provided by HGNC
Official Full Name
tripartite motif containing 9provided by HGNC
Primary source
HGNC:HGNC:16288
See related
Ensembl:ENSG00000100505 MIM:606555; AllianceGenome:HGNC:16288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF91; SPRING
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 15.3), gall bladder (RPKM 1.4) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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Location:
14q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (50975266..51095105, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (45181679..45446640, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (51441984..51561823, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903314 Neighboring gene PYGL intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5734 Neighboring gene glycogen phosphorylase L Neighboring gene Sharpr-MPRA regulatory region 6562 Neighboring gene uncharacterized LOC400212 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:51452525-51453231 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:51495109-51496308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8371 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:51706801-51707143 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8373 Neighboring gene thioredoxin related transmembrane protein 1 Neighboring gene uncharacterized LOC124903315

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. Wang Z, et al. Ann Clin Lab Sci, 2023 Jan. PMID 36889762
  2. TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway. Yang F, et al. Life Sci, 2020 Sep 15. PMID 32679146
  3. TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway. Lin Z, et al. Biomed Res Int, 2023. PMID 37124931, Free PMC Article
  4. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Zeng J, et al. Cell Rep, 2019 Apr 9. PMID 30970257, Free PMC Article
  5. Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression. Liu K, et al. Cell Rep, 2018 Apr 17. PMID 29669288

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A new SPRING in lipid metabolism.
    Title: A new SPRING in lipid metabolism.
  2. TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway.
    Title: TRIM9 Interacts with ZEB1 to Suppress Esophageal Cancer by Promoting ZEB1 Protein Degradation via the UPP Pathway.
  3. Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
    Title: Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
  4. Knockdown of TRIM9 attenuates irinotecaninduced intestinal mucositis in IEC6 cells by regulating DUSP6 expression via the P38 pathway.
    Title: Knockdown of TRIM9 attenuates irinotecan‑induced intestinal mucositis in IEC‑6 cells by regulating DUSP6 expression via the P38 pathway.
  5. TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-kappaB signaling pathway.
    Title: TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway.
  6. Findings reveal that TRIM9 is essential for resolving NF-kappaB-dependent neuroinflammation to promote recovery and repair after brain injury.
    Title: TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.
  7. TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine. MKK6 could also stabilize TRIM9s by promoting the phosphorylation of TRIM9s at Ser76/80 via p38, thereby blocking the ubiquitin-proteasome pathway.
    Title: Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression.
  8. TRIM9s undergoes Lys-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1, leading to the activation of IRF3 signaling.
    Title: TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1.
  9. Authors demonstrate that tripartite motif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK.
    Title: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.
  10. TRIM9 is a brain-specific negative regulator of the NF-kappaB pro-inflammatory signalling pathway.
    Title: Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of atypical psychosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM9
Names
RING finger protein 91
RING-type E3 ubiquitin transferase TRIM9
SNAP-25-interacting RING finger protein
homolog of rat RING finger Spring
tripartite motif-containing protein 9
NP_001374289.1
NP_001374290.1
NP_001374291.1
NP_001374292.1
NP_001374293.1
NP_001374294.1
NP_001374295.1
NP_001374296.1
NP_001374297.1
NP_001374298.1
NP_001374299.1
NP_001374300.1
NP_001374301.1
NP_001374302.1
NP_001374303.1
NP_001374304.1
NP_001374305.1
NP_001374306.1
NP_001374307.1
NP_001374308.1
NP_001374309.1
NP_055978.4
NP_443210.1
XP_011534691.1
XP_016876437.1
XP_047286861.1
XP_054231290.1
XP_054231291.1
XP_054231292.1
XP_054231293.1
XP_054231294.1
XP_054231295.1
XP_054231296.1
XP_054231297.1
XP_054231298.1
XP_054231299.1
XP_054231300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387360.1 → NP_001374289.1  E3 ubiquitin-protein ligase TRIM9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Consensus CDS
    CCDS91879.1
    UniProtKB/TrEMBL
    A0A804HIL7
    Related
    ENSP00000507131.1, ENST00000684578.1
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:620 → 785
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  2. NM_001387361.1 → NP_001374290.1  E3 ubiquitin-protein ligase TRIM9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:449 → 528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:616 → 781
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  3. NM_001387362.1 → NP_001374291.1  E3 ubiquitin-protein ligase TRIM9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:612 → 777
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  4. NM_001387363.1 → NP_001374292.1  E3 ubiquitin-protein ligase TRIM9 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:608 → 773
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  5. NM_001387364.1 → NP_001374293.1  E3 ubiquitin-protein ligase TRIM9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:606 → 771
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  6. NM_001387365.1 → NP_001374294.1  E3 ubiquitin-protein ligase TRIM9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:620 → 767
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  7. NM_001387366.1 → NP_001374295.1  E3 ubiquitin-protein ligase TRIM9 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:596 → 763
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  8. NM_001387367.1 → NP_001374296.1  E3 ubiquitin-protein ligase TRIM9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:449 → 528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:592 → 759
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  9. NM_001387368.1 → NP_001374297.1  E3 ubiquitin-protein ligase TRIM9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:557 → 722
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  10. NM_001387369.1 → NP_001374298.1  E3 ubiquitin-protein ligase TRIM9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:271 → 326
    BBC; B-Box C-terminal domain
    cd00063
    Location:380 → 459
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:547 → 712
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  11. NM_001387370.1 → NP_001374299.1  E3 ubiquitin-protein ligase TRIM9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:529 → 708
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  12. NM_001387371.1 → NP_001374300.1  E3 ubiquitin-protein ligase TRIM9 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 398
    BBC; B-Box C-terminal domain
    cd00063
    Location:452 → 531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:528 → 699
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  13. NM_001387372.1 → NP_001374301.1  E3 ubiquitin-protein ligase TRIM9 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:449 → 528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:525 → 696
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  14. NM_001387373.1 → NP_001374302.1  E3 ubiquitin-protein ligase TRIM9 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:529 → 682
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  15. NM_001387374.1 → NP_001374303.1  E3 ubiquitin-protein ligase TRIM9 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (6) summary
    smart00502
    Location:271 → 326
    BBC; B-Box C-terminal domain
    cd00063
    Location:380 → 459
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:456 → 609
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  16. NM_001387375.1 → NP_001374304.1  E3 ubiquitin-protein ligase TRIM9 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd12889
    Location:434 → 601
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  17. NM_001387376.1 → NP_001374305.1  E3 ubiquitin-protein ligase TRIM9 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd12889
    Location:434 → 583
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  18. NM_001387377.1 → NP_001374306.1  E3 ubiquitin-protein ligase TRIM9 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    cd00063
    Location:449 → 528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 49
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:223 → 271
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:5 → 52
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  19. NM_001387378.1 → NP_001374307.1  E3 ubiquitin-protein ligase TRIM9 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:271 → 326
    BBC; B-Box C-terminal domain
    cd12889
    Location:361 → 528
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd16755
    Location:5 → 52
    RING-HC_TRIM9; RING finger, HC subclass, found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19826
    Location:223 → 271
    Bbox2_TRIM9_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins
    cd19843
    Location:166 → 212
    Bbox1_TRIM9_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 9 (TRIM9) and similar proteins

  20. NM_001387379.1 → NP_001374308.1  E3 ubiquitin-protein ligase TRIM9 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:273 → 362
    BBC; B-Box C-terminal domain
    cd00063
    Location:416 → 495
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 49
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:223 → 271
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:5 → 52
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  21. NM_001387380.1 → NP_001374309.1  E3 ubiquitin-protein ligase TRIM9 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Conserved Domains (5) summary
    smart00502
    Location:271 → 326
    BBC; B-Box C-terminal domain
    cd00063
    Location:380 → 459
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:10 → 49
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cl00034
    Location:223 → 271
    Bbox_SF; B-box-type zinc finger superfamily
    cl17238
    Location:5 → 52
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  22. NM_015163.6 → NP_055978.4  E3 ubiquitin-protein ligase TRIM9 isoform 1

    See identical proteins and their annotated locations for NP_055978.4

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Consensus CDS
    CCDS9703.1
    UniProtKB/Swiss-Prot
    D3DSB7, D3DSB8, Q92557, Q96D24, Q96NI4, Q9C025, Q9C026, Q9C027
    Related
    ENSP00000298355.3, ENST00000298355.7
    Conserved Domains (5) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224 → 266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:9 → 38
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:529 → 700
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

  23. NM_052978.5 → NP_443210.1  E3 ubiquitin-protein ligase TRIM9 isoform 2

    See identical proteins and their annotated locations for NP_443210.1

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770
    Consensus CDS
    CCDS45105.1
    UniProtKB/Swiss-Prot
    Q9C026
    Related
    ENSP00000353561.4, ENST00000360392.4
    Conserved Domains (4) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224 → 266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:453 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl17238
    Location:5 → 52
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_170640.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  2. NR_170641.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  3. NR_170642.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  4. NR_170643.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  5. NR_170644.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  6. NR_170645.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  7. NR_170646.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  8. NR_170647.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  9. NR_170648.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  10. NR_170649.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  11. NR_170650.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  12. NR_170651.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

  13. NR_170652.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358334, AL591770

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    50975266..51095105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020948.2 → XP_016876437.1  E3 ubiquitin-protein ligase TRIM9 isoform X2

  2. XM_011536389.3 → XP_011534691.1  E3 ubiquitin-protein ligase TRIM9 isoform X1

    UniProtKB/Swiss-Prot
    Q9C026
    Related
    ENSP00000342970.5, ENST00000338969.9
    Conserved Domains (5) summary
    smart00502
    Location:273 → 399
    BBC; B-Box C-terminal domain
    smart00336
    Location:224 → 266
    BBOX; B-Box-type zinc finger
    cd00063
    Location:449 → 528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00162
    Location:9 → 38
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd12889
    Location:616 → 773
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

  3. XM_047430905.1 → XP_047286861.1  E3 ubiquitin-protein ligase TRIM9 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    45181679..45446640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375319.1 → XP_054231294.1  E3 ubiquitin-protein ligase TRIM9 isoform X7

    UniProtKB/Swiss-Prot
    D3DSB7, D3DSB8, Q92557, Q96D24, Q96NI4, Q9C025, Q9C026, Q9C027

  2. XM_054375324.1 → XP_054231299.1  E3 ubiquitin-protein ligase TRIM9 isoform X11

  3. XM_054375323.1 → XP_054231298.1  E3 ubiquitin-protein ligase TRIM9 isoform X10

  4. XM_054375322.1 → XP_054231297.1  E3 ubiquitin-protein ligase TRIM9 isoform X2

  5. XM_054375320.1 → XP_054231295.1  E3 ubiquitin-protein ligase TRIM9 isoform X8

  6. XM_054375317.1 → XP_054231292.1  E3 ubiquitin-protein ligase TRIM9 isoform X5

  7. XM_054375321.1 → XP_054231296.1  E3 ubiquitin-protein ligase TRIM9 isoform X9

  8. XM_054375318.1 → XP_054231293.1  E3 ubiquitin-protein ligase TRIM9 isoform X6

  9. XM_054375316.1 → XP_054231291.1  E3 ubiquitin-protein ligase TRIM9 isoform X4

    UniProtKB/TrEMBL
    A0A804HIL7

  10. XM_054375315.1 → XP_054231290.1  E3 ubiquitin-protein ligase TRIM9 isoform X1

  11. XM_054375325.1 → XP_054231300.1  E3 ubiquitin-protein ligase TRIM9 isoform X12

RNA

  1. XR_008488818.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C026.1 GenPept UniProtKB/Swiss-Prot:Q9C026

Gene LinkOut

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