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STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

Gene ID: 11329, updated on 7-Apr-2024

Summary

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Official Symbol
STK38provided by HGNC
Official Full Name
serine/threonine kinase 38provided by HGNC
Primary source
HGNC:HGNC:17847
See related
Ensembl:ENSG00000112079 MIM:606964; AllianceGenome:HGNC:17847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDR; NDR1
Summary
This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 16.7), colon (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36493892..36547479, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36314555..36368143, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461669..36515256, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17114 Neighboring gene ETV7 and PTX1 antisense RNA 1 Neighboring gene peroxisomal testis enriched protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24427 Neighboring gene PXT1 intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24429 Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene uncharacterized LOC124901558 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36514791-36515314 Neighboring gene MPRA-validated peak5783 silencer Neighboring gene MPRA-validated peak5784 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36544382-36545325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36561915-36562596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564442-36564942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564943-36565443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567225-36567726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567727-36568226 Neighboring gene MPRA-validated peak5786 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24432 Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe? Liu Y, et al. Int J Mol Sci, 2022 Sep 30. PMID 36232893, Free PMC Article
  2. STK38 is a PPARγ-interacting protein promoting adipogenesis. Qian K, et al. Adipocyte, 2021 Dec. PMID 34670478, Free PMC Article
  3. Asiatic acid promotes p21(WAF1/CIP1) protein stability through attenuation of NDR1/2 dependent phosphorylation of p21(WAF1/ CIP1) in HepG2 human hepatoma cells. Chen JY, et al. Asian Pac J Cancer Prev, 2014. PMID 24568526
  4. Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Hergovich A. Cell Biosci, 2013 Aug 28. PMID 23985307, Free PMC Article
  5. The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition. Enomoto A, et al. Eur J Cancer, 2013 Nov. PMID 23886587

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
    Title: Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
  2. Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
    Title: Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
  3. NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties.
    Title: NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties.
  4. STK38 is a PPARgamma-interacting protein promoting adipogenesis.
    Title: STK38 is a PPARγ-interacting protein promoting adipogenesis.
  5. The STK38-XPO1 axis, a new actor in physiology and cancer.
    Title: The STK38-XPO1 axis, a new actor in physiology and cancer.
  6. our results reveal STK38 as an activator of XPO1, behaving as a gatekeeper of nuclear export. These observations establish a novel mechanism of XPO1-dependent cargo export regulation by phosphorylation of XPO1's C-terminal auto-inhibitory domain.
    Title: STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.
  7. The activation segment of NDR1 influences interaction with MST1/MST2 and Furry.
    Title: Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
  8. Relied on its interaction with serine/threonine-protein kinase 38 (Stk38) to inhibit ubiquitination.
    Title: Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
  9. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
    Title: Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
  10. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1.
    Title: The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase 38
Names
NDR1 protein kinase
Ndr Ser/Thr kinase-like protein
nuclear Dbf2-related kinase 1
NP_001292031.1
NP_009202.1
XP_016865715.1
XP_047274095.1
XP_047274096.1
XP_047274097.1
XP_047274098.1
XP_047274099.1
XP_047274100.1
XP_054210120.1
XP_054210121.1
XP_054210122.1
XP_054210123.1
XP_054210124.1
XP_054210125.1
XP_054210126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305102.2 → NP_001292031.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_001292031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, BC095413, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208, Q503A1
    UniProtKB/TrEMBL
    B2R6F9
    Conserved Domains (1) summary
    cd05628
    Location:87 → 462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

  2. NM_007271.4 → NP_009202.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_009202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012085, CB852856, DA459946
    Consensus CDS
    CCDS4822.1
    UniProtKB/Swiss-Prot
    Q15208, Q503A1
    UniProtKB/TrEMBL
    B2R6F9
    Related
    ENSP00000229812.7, ENST00000229812.8
    Conserved Domains (1) summary
    cd05628
    Location:87 → 462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36493892..36547479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010226.2 → XP_016865715.1  serine/threonine-protein kinase 38 isoform X2

    UniProtKB/TrEMBL
    B2R6F9
    Conserved Domains (2) summary
    smart00220
    Location:89 → 382
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:87 → 424
    PKc_like; Protein Kinases, catalytic domain

  2. XM_047418142.1 → XP_047274098.1  serine/threonine-protein kinase 38 isoform X2

  3. XM_047418140.1 → XP_047274096.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  4. XM_047418143.1 → XP_047274099.1  serine/threonine-protein kinase 38 isoform X2

  5. XM_047418141.1 → XP_047274097.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  6. XM_047418139.1 → XP_047274095.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  7. XM_047418144.1 → XP_047274100.1  serine/threonine-protein kinase 38 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36314555..36368143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354149.1 → XP_054210124.1  serine/threonine-protein kinase 38 isoform X2

  2. XM_054354148.1 → XP_054210123.1  serine/threonine-protein kinase 38 isoform X2

  3. XM_054354146.1 → XP_054210121.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  4. XM_054354150.1 → XP_054210125.1  serine/threonine-protein kinase 38 isoform X2

  5. XM_054354147.1 → XP_054210122.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  6. XM_054354145.1 → XP_054210120.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q15208, Q503A1

  7. XM_054354151.1 → XP_054210126.1  serine/threonine-protein kinase 38 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15208.1 GenPept UniProtKB/Swiss-Prot:Q15208

Gene LinkOut

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